Elkhonon Goldberg | |
|---|---|
 Elkhonon Goldberg, Neuropsychologist and Cognitive Neuroscientist. | |
| Born | 1946 (age 76–77) |
| Alma mater | Moscow State University |
| Scientific career | |
| Fields | Neuropsychology |
Elkhonon Goldberg (born 1946) is a neuropsychologist and cognitive neuroscientist known for his work in hemispheric specialization and the "novelty-routinization" theory.
Goldberg studied at Moscow State University with the great neuropsychologist Alexander Luria and moved to the United States in 1974. He is currently a Clinical Professor of Neurology at New York University School of Medicine, Diplomate of The American Board of Professional Psychology in Clinical Neuropsychology, and Co-Founder and Chief Scientific Advisor of SharpBrains, an online brain fitness center. He offers post-doctoral training in Neuropsychology at Fielding Graduate University. Elkhonon Goldberg is the Founding Director of Luria Neuroscience Institute (LNI), [1] an organization founded with the purpose of advancing research and disseminating knowledge about the brain and the mind. He describes himself as an atheist "with agnostic tendencies". [2]
At Moscow State University, Goldberg studied psychology and mathematics and was among the early proponents of the discipline known today as computational neuroscience. In the United States Goldberg's work has been more clinical in nature. His research has focused on the function of the frontal lobes, hemispheric specialization, memory, cognitive aging, and general theory of functional cortical organization.
Among the early critics of the fashionable notion of neocortical modularity, he introduced the notion of "cognitive gradient" to capture the distributed and emergent properties of functional cortical organization. [3]
Goldberg's work on frontal lobe functions includes the discovery of the "reticulo-frontal disconnection" syndrome, functional lateralization and gender differences in the prefrontal cortex. His work on memory includes the description of relatively pure retrograde amnesia without anterograde amnesia, which in turn has led to the elucidation of the role of brain stem arousal mechanisms in memory.
In clinical practice, Goldberg was among the early proponents of "cognitive fitness," purporting to harness the effects of lifelong neuroplasticity to delay and even reverse the effects of cognitive aging. First introduced by Michael Merzenich, the concept has gained the support of a number of leading neuroscientists. Nonetheless, it remains controversial and further research is required to validate it.
Goldberg is an author of a number of scientific journal articles and book chapters, as well as three books: Contemporary Neuropsychology and the Legacy of Luria; The Executive Brain: Frontal Lobes and the Civilized Mind; and The Wisdom Paradox: How Your Mind Can Grow Stronger As Your Brain Grows Older.
His work on hemispheric specialization culminated in the "novelty-routinization" theory positing that (for the predominantly right-handed population) the two cerebral hemispheres are differentially involved in processing novel, unknown information (the right hemisphere) and processing in terms of stable pattern-recognition devices for known situations of mental routine (the left hemisphere). As for left-handers and ambidextrals, Goldberg indicates that the two hemispheres are less differentiated in function and structure. For these individuals there may be instances in which the left hemisphere takes the role of novelty processing and the right the routine processing.
Specifically, the right hemisphere favors the "heteromodal association cortex" while the left favors the "modality-specific association cortex", and both are engaged in complex information processing. The latter deals solely with processing information arriving from individual sensory systems, such as visual, auditory, and sensory ones. This kind of cortex, favoring more local connections between adjacent cortical regions, "dismantles the world around us to separate representations. ... think of an object in a three-dimensional space projected onto the x, y, z coordinates...". On the other hand, the heteromodal association cortex, favoring distant inter-cortical connections, integrates information arriving from sensory channels, or puts "the synthetic picture of the multimedia world around us back together." Goldberg likens these differences in connectivity thus: the left hemisphere is like a fleet of taxicabs that traverses short town-like distances while the right is like a fleet of airplanes that traverses large continental distances. [4]
The novelty-routinization theory incorporates the more traditional distinction between verbal and nonverbal functions as a special case, but is more dynamic in nature, allows for evolutionary continuities, and provides a neurodevelopmental framework.
Alien hand syndrome (AHS) or Dr. Strangelove syndrome is a category of conditions in which a person experiences their limbs acting seemingly on their own, without conscious control over the actions. There are a variety of clinical conditions that fall under this category, which most commonly affects the left hand. There are many similar terms for the various forms of the condition, but they are often used inappropriately. The affected person may sometimes reach for objects and manipulate them without wanting to do so, even to the point of having to use the controllable hand to restrain the alien hand. Under normal circumstances however, given that intent and action can be assumed to be deeply mutually entangled, the occurrence of alien hand syndrome can be usefully conceptualized as a phenomenon reflecting a functional "disentanglement" between thought and action.
Neuropsychology is a branch of psychology concerned with how a person's cognition and behavior are related to the brain and the rest of the nervous system. Professionals in this branch of psychology often focus on how injuries or illnesses of the brain affect cognitive and behavioral functions.
Cognitive neuropsychology is a branch of cognitive psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. Cognitive psychology is the science that looks at how mental processes are responsible for the cognitive abilities to store and produce new memories, produce language, recognize people and objects, as well as our ability to reason and problem solve. Cognitive neuropsychology places a particular emphasis on studying the cognitive effects of brain injury or neurological illness with a view to inferring models of normal cognitive functioning. Evidence is based on case studies of individual brain damaged patients who show deficits in brain areas and from patients who exhibit double dissociations. Double dissociations involve two patients and two tasks. One patient is impaired at one task but normal on the other, while the other patient is normal on the first task and impaired on the other. For example, patient A would be poor at reading printed words while still being normal at understanding spoken words, while the patient B would be normal at understanding written words and be poor at understanding spoken words. Scientists can interpret this information to explain how there is a single cognitive module for word comprehension. From studies like these, researchers infer that different areas of the brain are highly specialised. Cognitive neuropsychology can be distinguished from cognitive neuroscience, which is also interested in brain-damaged patients, but is particularly focused on uncovering the neural mechanisms underlying cognitive processes.
Alexander Romanovich Luria was a Soviet neuropsychologist, often credited as a father of modern neuropsychology. He developed an extensive and original battery of neuropsychological tests during his clinical work with brain-injured victims of World War II, which are still used in various forms. He made an in-depth analysis of the functioning of various brain regions and integrative processes of the brain in general. Luria's magnum opus, Higher Cortical Functions in Man (1962), is a much-used psychological textbook which has been translated into many languages and which he supplemented with The Working Brain in 1973.
The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus.
The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain.
The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere. It is parted from the parietal lobe by a groove between tissues called the central sulcus and from the temporal lobe by a deeper groove called the lateral sulcus. The most anterior rounded part of the frontal lobe is known as the frontal pole, one of the three poles of the cerebrum.
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.
Clinical neuropsychology is a sub-field of cognitive science and psychology concerned with the applied science of brain-behaviour relationships. Clinical neuropsychologists use this knowledge in the assessment, diagnosis, treatment, and or rehabilitation of patients across the lifespan with neurological, medical, neurodevelopmental and psychiatric conditions, as well as other cognitive and learning disorders. The branch of neuropsychology associated with children and young people is pediatric neuropsychology.
The Wisconsin Card Sorting Test (WCST) is a neuropsychological test of set-shifting, which is the capability to show flexibility when exposed to changes in reinforcement. The WCST was written by David A. Grant and Esta A. Berg. The Professional Manual for the WCST was written by Robert K. Heaton, Gordon J. Chelune, Jack L. Talley, Gary G. Kay, and Glenn Curtiss.
Witzelsucht is a set of pure and rare neurological symptoms characterized by a tendency to make puns, or tell inappropriate jokes or pointless stories in socially inappropriate situations. It makes one unable to read sarcasm.
The lobes of the brain are the major identifiable zones of the human cerebral cortex, and they comprise the surface of each hemisphere of the cerebrum. The two hemispheres are roughly symmetrical in structure, and are connected by the corpus callosum. They traditionally have been divided into four lobes, but are today considered as having six lobes each. The lobes are large areas that are anatomically distinguishable, and are also functionally distinct to some degree. Each lobe of the brain has numerous ridges, or gyri, and furrows, the sulci that constitute further subzones of the cortex. The expression "lobes of the brain" usually refers only to those of the cerebrum, not to the distinct areas of the cerebellum.
The lateralization of brain function is the tendency for some neural functions or cognitive processes to be specialized to one side of the brain or the other. The median longitudinal fissure separates the human brain into two distinct cerebral hemispheres, connected by the corpus callosum. Although the macrostructure of the two hemispheres appears to be almost identical, different composition of neuronal networks allows for specialized function that is different in each hemisphere.
In cognitive science and neuropsychology, executive functions are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals. Executive functions include basic cognitive processes such as attentional control, cognitive inhibition, inhibitory control, working memory, and cognitive flexibility. Higher-order executive functions require the simultaneous use of multiple basic executive functions and include planning and fluid intelligence.
In neuroscience, functional specialization is a theory which suggests that different areas in the brain are specialized for different functions.
The Luria–Nebraska Neuropsychological Battery (LNNB) is a standardized test that identifies neuropsychological deficiencies by measuring functioning on fourteen scales. It evaluates learning, experience, and cognitive skills. The test was created by Charles Golden in 1981 and based on previous work by Alexander Luria that emphasizes a qualitative instead of quantitative approach. The original, adult version is for use with ages fifteen and over, while the Luria–Nebraska Neuropsychological Battery for Children (LNNB-C) can be used with ages eight to twelve; both tests take two to three hours to administer. The LNNB has 269 items divided among fourteen scales, which are motor, rhythm, tactile, visual, receptive speech, expressive speech, writing, reading, arithmetic, memory, intellectual processes, pathognomonic, left hemisphere, and right hemisphere. The test is graded on scales that are correlated to regions of the brain to help identify which region may be damaged. The Luria–Nebraska has been found to be reliable and valid; it is comparable in this sense to other neuropsychological tests in its ability to differentiate between brain damage and mental illness. The test is used to diagnose and determine the nature of cognitive impairment, including the location of the brain damage, to understand the patient's brain structure and abilities, to pinpoint causes of behavior, and to help plan treatment.
Disconnection syndrome is a general term for a collection of neurological symptoms caused – via lesions to associational or commissural nerve fibres – by damage to the white matter axons of communication pathways in the cerebrum, independent of any lesions to the cortex. The behavioral effects of such disconnections are relatively predictable in adults. Disconnection syndromes usually reflect circumstances where regions A and B still have their functional specializations except in domains that depend on the interconnections between the two regions.
Luria Neuroscience Institute (LNI) and its not-for-profit arm Luria Scientific Foundation (LNF) were founded in 2011 with the broad purpose of advancing research in cognitive neuroscience and neuropsychology, and disseminating knowledge in these areas. Fostering international scientific and educational collaborations is among LNI's priorities. The Institute has been named in honor of Alexander Luria, one of the founding fathers of modern neuropsychology as a scientific discipline. LNI is based in New York City and is directed by Elkhonon Goldberg, a student and close associate of Alexander Luria.
Developmental neuropsychology combines the fields of neuroscience and developmental psychology, while drawing from various other related disciplines. It examines the relationship of behavior and brain function throughout the course of an individual's lifespan, though often emphasis is put on childhood and adolescence when the majority of brain development occurs. Research tends to focus on development of important behavioral functions like perception, language, and other cognitive processes. Studies in this field are often centered around children or other individuals with developmental disorders or various kinds of brain related trauma or injury. A key concept of this field is that looks at and attempts to relate the psychological aspects of development, such as behavior, comprehension, cognition, etc., to the specific neural structures; it draws parallels between behavior and mechanism in the brain. Research in this field involves various cognitive tasks and tests as well as neuroimaging. Some of the many conditions studied by developmental neuropsychologists include congenital or acquired brain damage, autism spectrum disorder, attention deficit disorder, executive dysfunction, seizures, intellectual disabilities, obsessive compulsive disorder, stuttering, schizophrenia, developmental aphasia, and other learning delays such as dyslexia, dysgraphia, and dyspraxia.
Donald Thomas Stuss OC, OOnt, FRSC, FCAHS was a Canadian neuropsychologist who studied the frontal lobes of the human brain. He also directed the Rotman Research Institute at Baycrest from 1989 until 2009 and the Ontario Brain Institute from 2011 until 2016.
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| Brain functions | |
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