Eric Oldfield (academic)

Last updated
Eric Oldfield
Eric Oldfield.png
Born1948
Citizenship British
Education Bristol University (B.Sc. 1969; D.Sc. 1982)
Sheffield University (Ph.D. 1972)
Indiana University (Post-Doc 1972–1974)
Massachusetts Institute of Technology (Visiting Scientist 1974–1975)
Known for NMR Spectroscopy and Drug Discovery
Awards The Meldola Medal, Royal Society of Chemistry
The Colworth Medal, Biochemical Society
Award in Pure Chemistry, American Chemical Society
Award in Spectroscopy, Royal Society of Chemistry
Award in Soft Matter and Biophysical Chemistry, Royal Society of Chemistry
Avanti Award in Lipids, Biophysical Society
Katz Basic Science Prize, American Heart Association
Scientific career
Fields Physical Chemistry, Chemical Biology, Microbiology, Parasitology
Institutions University of Illinois at Urbana-Champaign
Thesis "Spectroscopic Studies of Lipids and Biological Membranes" (1972)
Doctoral advisor Dennis Chapman
Other academic advisors Jake MacMillan
Geoffrey Eglinton
Adam Allerhand
John S. Waugh

Eric Oldfield (born 1948) is a British chemist, the Harriet A. Harlin Professor of Chemistry and a professor of Biophysics at the University of Illinois at Urbana-Champaign. [1] He is known for his work in nuclear magnetic resonance spectroscopy of lipids, proteins, and membranes; of inorganic solids; in computational chemistry, and in microbiology and parasitology. He has received a number of recognitions for his work, including the American Chemical Society's Award in Pure Chemistry, the Royal Society of Chemistry's Meldola Medal and the Biochemical Society's Colworth Medal, and he is a member of the American Association for the Advancement of Science, a Fellow of the Royal Society of Chemistry, and a Fellow of the American Physical Society.

Contents

Early life and education

Oldfield was born in London, England on May 23, 1948. He attended the University in Bristol doing research with Jake MacMillan on diterpenes and Geoffrey Eglinton on lipids and isoprenoids. He graduated with a Bachelor of Science degree in 1969. He obtained a PhD in Biophysical Chemistry from the University of Sheffield in 1972, with Dennis Chapman, developing NMR methods to study lipid and membrane structure. He worked as a Research Associate and EMBO Postdoctoral Fellow at Indiana University with Adam Allerhand, on the development of high-resolution NMR of proteins (1972–1974) [2] and was then a Visiting Scientist at MIT with John S. Waugh (1974-1975), working on solid-state NMR. [3]

Career

Oldfield joined the Department of Chemistry at the University of Illinois at Urbana-Champaign in 1975 as an assistant Professor of Chemistry. He was promoted to associate professor in 1980 and was a Professor from 1982 to 2002. He was then an Alumni Research Professor of Chemistry from 2003 to 2013 and since then has been the Harriet A. Harlin Professor of Chemistry. He has also been a professor of biophysics in the Center for Computational Biology and Biophysics since 1995 and was a Fellow in the Center for Advanced Study in 1979, a Richard G. and Carole J. Cline University Senior Scholar in 1995, and an Associate in the Center for Advanced Study in 2000. He has authored 450 publications and as of 2023, has an h-index of 104 with 35,000 citations, according to Google Scholar [4] and holds nine issued patents from the United States Patent and Trademark Office. [5]

Research

Oldfield is known for his research in nuclear magnetic resonance (NMR) spectroscopy, and drug discovery. His invention of deuterium and proton NMR methods led to new ways to study the structures of lipids and membranes; his carbon-13 NMR and quantum chemical developments led to new ways to investigate protein structures; his investigations of quadrupolar nuclei led to new research in materials science, geochemistry and catalysis, and his more recent research using NMR, computational and crystallographic methods has led to the development of new therapeutic approaches to treating both infectious diseases and cancer, targeting lipid biosynthesis.

NMR of lipids and membranes

In the 1970s and 1980s Oldfield developed ways to investigate lipid and membrane structure including the use of 2H nuclear magnetic resonance (NMR) spectroscopy of labelled compounds. [6] [7] This method enabled the determination of the static and dynamic structures of lipids, and how they interact with proteins and sterol molecules such as cholesterol. [8] In addition, he developed 1H and 13C magic-angle sample-spinning methods to investigate lipid membranes without the need for isotopic labeling. The magic-angle technique was not thought to be applicable to 1H NMR (due to strong dipolar interactions), but he showed that due to fast axial diffusion, these interactions were scaled and that remarkably high-resolution spectra could be obtained. [9]

NMR of proteins

In the early 1970s, while working with Adam Allerhand, Oldfield reported the first high-resolution 13C NMR spectra of proteins—lysozyme, myoglobin and cytochrome c—in which numerous single carbon atom sites could be resolved and assigned. [10] [11] The origins of the chemical shift non-equivalencies observed due to folding remained unexplained until 1993 when he showed that 13C and 15N chemical shifts in proteins could be well predicted by using quantum chemical methods. He reasoned that since the chemical shift is essentially a local phenomenon, it might be possible to compute chemical shifts just by using small peptide fragments and a “locally dense” basis set, and this turned out to be correct. [12] His early work also led to the demonstration that computed chemical shift tensors could be used in protein structure refinement. [13] Moreover, he showed that the chemical shifts of non-native species in proteins such as 19F nuclei, could be also be computed, and were due to electric field effects. [14]

Quantum chemistry

Followed by the observation that chemical shifts in proteins could be computed by using quantum chemical methods, Oldfield began a series of investigations of other spectroscopic properties [15] including Mössbauer isomer shifts [16] and quadrupole splittings, [17] hyperfine shifts in metalloproteins, [18] spin-spin couplings, [19] and electric field gradients, as well as the effects of hydrogen bonding on chemical shifts. [20]

NMR inorganic solids

Oldfield began to investigate structures of a variety of inorganic solids in the 1980s. He showed that high-resolution spectra of quadrupolar nuclei (such as 17O, 23Na) could be obtained by using variable-angle sample-spinning, [21] spin echo, [22] as well as spectral deconvolution methods. [23] In his collaborative research with R. James Kirkpatrick, he investigated the 29Si magic-angle sample-spinning NMR spectra of a wide range of natural and synthetic silicates, [24] showing that both Si-O bond length-chemical shift and bond strength-chemical shift relationships were useful tools for investigating the structures of crystalline silicates and, more importantly, silicate glasses, clays, and zeolites that cannot be examined by single crystal X-ray or neutron diffraction methods. He also worked on investigating Pt/Ru direct methanol oxidation fuel cell catalysts using 13C and 195Pt NMR, in collaboration with A. Wieckowksi, which clarified the mechanism of enhanced CO tolerance in Pt/Ru versus pure Pt catalysts. [25]

Antibiotics

In 1999, Oldfield shifted his research to more biomedical applications. Working in collaboration with Julio Urbina and Roberto Docampo, his group found, using 31P NMR spectroscopy, that the parasitic protozoan Trypanosoma cruzi , the causative agent of Chagas disease, contained very high levels of diphosphate, and that diphosphate analogs, bisphosphonates used clinically to treat bone resorption diseases, killed these parasites. [26] as well as others. [27] He also discovered that the bisphosphonate pamidronate cured mice of leishmaniasis [28] and proposed that farnesyl diphosphate synthase (FPPS) can be used as the target of bisphosphonate drugs [29]

Oldfield then discovered another compound that killed T. cruzi, the antiarrhythmic drug amiodarone, and that it acted synergistically with the azole drug posaconazole. [30] He then began to investigate antibacterial agents. The human pathogen Staphylococcus aureus contains a gold-colored virulence factor called staphyloxanthin that protects the bacterium from killing by reactive oxygen species. [31] Recognizing that the biosynthesis of the carotenoid pigment had similarities to the first steps in cholesterol biosynthesis, he synthesized a range of cholesterol biosynthesis inhibitors and tested them in S. aureus and in mice models of infection finding potent activity against the protein target dehydrosqualene synthase, the bacterium, and in a mice model of infection. [32] His group also showed that some drugs and drug leads that target tuberculosis bacteria function as protonophore uncouplers and in some cases they can also target isoprenoid biosynthesis, leading to potent multi-target inhibition. [33]

Anti-cancer drug leads

In 2012, Oldfield's group synthesized lipophilic analogs of the clinical bisphosphonate drugs zoledronate and risedronate, to prevent unwanted binding to bone mineral, and found they had potent anti-malarial activity. [34] Additionally, they had potent activity in a combination therapy with rapamycin in tumor cells and in mice, by targeting protein prenylation [35] with inhibition of protein prenylation also leading to activity as vaccine adjuvants. [36] Mechanistically, FPPS inhibition affects cell signaling, but it also leads to accumulation of isopentenyl diphosphate and dimethylallyl diphosphate, compounds that activate γδT cells by binding to butyrophilins in target cells [37] and this T cell activation led to tumor cell killing. [38] His group also showed that some clinically used bisphosphonate drugs are converted to analogs of adenosine triphosphate that function by inhibiting cell signaling pathways. [39]

Isoprenoid synthesis

Oldfield and his collaborators have reported the structures and mechanisms of action of many proteins involved in isoprenoid biosynthesis, focusing on the modular structures found. [40] They successfully predicted the αβγ tri-domain found in diterpene cyclases. [41] Furthermore, they used electron paramagnetic resonance and X-ray crystallography to develop the organometallic mechanism of action of the unusual 4Fe-4S proteins IspG and IspH involved in the early stages of isoprenoid biosynthesis, [42] and also used X-ray methods for providing mechanisms of action for the terpene cyclases. [43]

Awards

Selected articles

Related Research Articles

<span class="mw-page-title-main">Lipid</span> Substance of biological origin that is not soluble in nonpolar solvents

Lipids are a broad group of organic compounds which include fats, waxes, sterols, fat-soluble vitamins, monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries, and in nanotechnology.

<span class="mw-page-title-main">Nuclear magnetic resonance spectroscopy</span> Laboratory technique

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique based on re-orientation of atomic nuclei with non-zero nuclear spins in an external magnetic field. This re-orientation occurs with absorption of electromagnetic radiation in the radio frequency region from roughly 4 to 900 MHz, which depends on the isotopic nature of the nucleus and increased proportionally to the strength of the external magnetic field. Notably, the resonance frequency of each NMR-active nucleus depends on its chemical environment. As a result, NMR spectra provide information about individual functional groups present in the sample, as well as about connections between nearby nuclei in the same molecule. As the NMR spectra are unique or highly characteristic to individual compounds and functional groups, NMR spectroscopy is one of the most important methods to identify molecular structures, particularly of organic compounds.

<span class="mw-page-title-main">Solid-state nuclear magnetic resonance</span>

Solid-state NMR (ssNMR) spectroscopy is a technique for characterizing atomic level structure in solid materials e.g. powders, single crystals and amorphous samples and tissues using nuclear magnetic resonance (NMR) spectroscopy. The anisotropic part of many spin interactions are present in solid-state NMR, unlike in solution-state NMR where rapid tumbling motion averages out many of the spin interactions. As a result, solid-state NMR spectra are characterised by larger linewidths than in solution state NMR, which can be utilized to give quantitative information on the molecular structure, conformation and dynamics of the material. Solid-state NMR is often combined with magic angle spinning to remove anisotropic interactions and improve the resolution as well as the sensitivity of the technique.

<span class="mw-page-title-main">Molecular biophysics</span> Interdisciplinary research area

Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms of molecular structure, structural organization, and dynamic behaviour at various levels of complexity. This discipline covers topics such as the measurement of molecular forces, molecular associations, allosteric interactions, Brownian motion, and cable theory. Additional areas of study can be found on Outline of Biophysics. The discipline has required development of specialized equipment and procedures capable of imaging and manipulating minute living structures, as well as novel experimental approaches.

<span class="mw-page-title-main">Residual dipolar coupling</span>

The residual dipolar coupling between two spins in a molecule occurs if the molecules in solution exhibit a partial alignment leading to an incomplete averaging of spatially anisotropic dipolar couplings.

Adriaan "Ad" Bax is a Dutch-American molecular biophysicist. He was born in the Netherlands and is the Chief of the Section on Biophysical NMR Spectroscopy at the National Institutes of Health. He is known for his work on the methodology of biomolecular NMR spectroscopy. He is a corresponding member of the Royal Netherlands Academy of Arts and Sciences, a member of the National Academy of Sciences, a fellow of the American Academy of Arts and Sciences, and a Foreign Member of the Royal Society.

<span class="mw-page-title-main">Farnesyl-diphosphate farnesyltransferase</span> Class of enzymes

Squalene synthase (SQS) or farnesyl-diphosphate:farnesyl-diphosphate farnesyl transferase is an enzyme localized to the membrane of the endoplasmic reticulum. SQS participates in the isoprenoid biosynthetic pathway, catalyzing a two-step reaction in which two identical molecules of farnesyl pyrophosphate (FPP) are converted into squalene, with the consumption of NADPH. Catalysis by SQS is the first committed step in sterol synthesis, since the squalene produced is converted exclusively into various sterols, such as cholesterol, via a complex, multi-step pathway. SQS belongs to squalene/phytoene synthase family of proteins.

<span class="mw-page-title-main">Lanosterol synthase</span> Mammalian protein found in Homo sapiens

Lanosterol synthase (EC 5.4.99.7) is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene.

Herbert Sander Gutowsky was an American chemist who was a professor of chemistry at the University of Illinois Urbana-Champaign. Gutowsky was the first to apply nuclear magnetic resonance (NMR) methods to the field of chemistry. He used nuclear magnetic resonance spectroscopy to determine the structure of molecules. His pioneering work developed experimental control of NMR as a scientific instrument, connected experimental observations with theoretical models, and made NMR one of the most effective analytical tools for analysis of molecular structure and dynamics in liquids, solids, and gases, used in chemical and medical research, His work was relevant to the solving of problems in chemistry, biochemistry, and materials science, and has influenced many of the subfields of more recent NMR spectroscopy.

<span class="mw-page-title-main">Diphosphomevalonate decarboxylase</span> InterPro Family

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase, is an enzyme that catalyzes the chemical reaction

In enzymology, a geranyltranstransferase is an enzyme that catalyzes the chemical reaction

Nuclear magnetic resonance crystallography is a method which utilizes primarily NMR spectroscopy to determine the structure of solid materials on the atomic scale. Thus, solid-state NMR spectroscopy would be used primarily, possibly supplemented by quantum chemistry calculations, powder diffraction etc. If suitable crystals can be grown, any crystallographic method would generally be preferred to determine the crystal structure comprising in case of organic compounds the molecular structures and molecular packing. The main interest in NMR crystallography is in microcrystalline materials which are amenable to this method but not to X-ray, neutron and electron diffraction. This is largely because interactions of comparably short range are measured in NMR crystallography.

Food physical chemistry is considered to be a branch of Food chemistry concerned with the study of both physical and chemical interactions in foods in terms of physical and chemical principles applied to food systems, as well as the applications of physical/chemical techniques and instrumentation for the study of foods. This field encompasses the "physiochemical principles of the reactions and conversions that occur during the manufacture, handling, and storage of foods."

<span class="mw-page-title-main">Joachim Seelig</span> German physical chemist (born 1942)

Joachim Heinrich Seelig is a German physical chemist and specialist in NMR Spectroscopy. He is one of the founding fathers of the Biozentrum of the University of Basel. He reached emeritus status in 2012.

Protein chemical shift prediction is a branch of biomolecular nuclear magnetic resonance spectroscopy that aims to accurately calculate protein chemical shifts from protein coordinates. Protein chemical shift prediction was first attempted in the late 1960s using semi-empirical methods applied to protein structures solved by X-ray crystallography. Since that time protein chemical shift prediction has evolved to employ much more sophisticated approaches including quantum mechanics, machine learning and empirically derived chemical shift hypersurfaces. The most recently developed methods exhibit remarkable precision and accuracy.

<span class="mw-page-title-main">Gareth A. Morris</span> British scientist

Gareth Alun Morris FRS is a Professor of Physical Chemistry, in the School of Chemistry at the University of Manchester.

<span class="mw-page-title-main">G. Marius Clore</span> Molecular biophysicist, structural biologist

G. Marius Clore MAE, FRSC, FMedSci, FRS is a British-born, American molecular biophysicist and structural biologist. He was born in London, U.K. and is a dual U.S./U.K. Citizen. He is a Member of the National Academy of Sciences, a Fellow of the Royal Society, a NIH Distinguished Investigator, and the Chief of the Molecular and Structural Biophysics Section in the Laboratory of Chemical Physics of the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. National Institutes of Health. He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. Clore's discovery of previously undetectable, functionally significant, rare transient states of macromolecules has yielded fundamental new insights into the mechanisms of important biological processes, and in particular the significance of weak interactions and the mechanisms whereby the opposing constraints of speed and specificity are optimized. Further, Clore's work opens up a new era of pharmacology and drug design as it is now possible to target structures and conformations that have been heretofore unseen.

<span class="mw-page-title-main">Mei Hong (chemist)</span> Chinese-American chemist

Mei Hong is a Chinese-American biophysical chemist and professor of chemistry at the Massachusetts Institute of Technology. She is known for her creative development and application of solid-state nuclear magnetic resonance (ssNMR) spectroscopy to elucidate the structures and mechanisms of membrane proteins, plant cell walls, and amyloid proteins. She has received a number of recognitions for her work, including the American Chemical Society Nakanishi Prize in 2021, Günther Laukien Prize in 2014, the Protein Society Young Investigator award in 2012, and the American Chemical Society’s Pure Chemistry award in 2003.

<span class="mw-page-title-main">Discovery and development of bisphosphonates</span> Drugs used to treat bone disorders

Bisphosphonates are an important class of drugs originally commercialised in the mid to late 20th century. They are used for the treatment of osteoporosis and other bone disorders that cause bone fragility and diseases where bone resorption is excessive. Osteoporosis is common in post-menopausal women and patients in corticosteroid treatment where biphosphonates have been proven a valuable treatment and also used successfully against Paget's disease, myeloma, bone metastases and hypercalcemia. Bisphosphonates reduce breakdown of bones by inhibiting osteoclasts, they have a long history of use and today there are a few different types of bisphosphonate drugs on the market around the world.

<span class="mw-page-title-main">Alfred G. Redfield</span> American molecular biologist, physicist

Alfred G. Redfield was an American physicist and biochemist. In 1955 he published the Redfield relaxation theory, effectively moving the practice of NMR or Nuclear magnetic resonance from the realm of classical physics to the realm of semiclassical physics. He continued to find novel magnetic resonance applications to solve real-world problems throughout his life.

References

  1. "Eric Oldfield | Chemistry at Illinois". chemistry.illinois.edu.
  2. Allerhand, Adam; Childers, RayF; Oldfield, Eric (August 1, 1973). "Carbon-13 fourier transform nmr at 14.2 kg in a 20 mm probe". Journal of Magnetic Resonance. 11 (2): 272–278. Bibcode:1973JMagR..11..272A. doi:10.1016/0022-2364(73)90013-9 via ScienceDirect.
  3. "Chemistry Tree - John S. Waugh". academictree.org.
  4. "Eric Oldfield". scholar.google.com.
  5. "Eric Oldfield Inventions, Patents and Patent Applications – Justia Patents Search". patents.justia.com.
  6. "deuteron resonance:A novel approach to the study of hydrocarbon chain mobility in membrane systems" (PDF).
  7. Oldfield, Eric; Meadows, Michael; Rice, David; Jacobs, Russell (July 11, 1978). "Spectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance investigation of the effects of cholesterol in model systems". Biochemistry. 17 (14): 2727–2740. doi:10.1021/bi00607a006. PMID   687560.
  8. Seelig, Joachim (1977). "Deuterium magnetic resonance: theory and application to lipid membranes". Quarterly Reviews of Biophysics. 10 (3): 353–418. doi:10.1017/S0033583500002948. PMID   335428. S2CID   33372264.
  9. Forbes, Jeffrey; Bowers, John; Shan, Xi; Moran, Liam; Oldfield, Eric; Moscarello, Mario A. (1988). "Some new developments in solid-state nuclear magnetic resonance spectroscopic studies of lipids and biological membranes, including the effects of cholesterol in model and natural systems". Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. 84 (11): 3821. doi:10.1039/F19888403821.
  10. Allerhand, Adam; Childres, Ray F.; Oldfield, Eric (1973). "Natural-abundance carbon-13 nuclear magnetic resonance studies in 20-mm sample tubes. Numerous single-carbon resonances of hen egg-white lysozyme". Biochemistry. 12 (7): 1335–1341. doi:10.1021/bi00731a013. PMID   4735301.
  11. Oldfield, Eric; Allerhand, Adam (1973). "Cytochrome c. Observation of Numerous Single-Carbon Sites of the Reduced and Oxidized Species by Means of Natural-Abundance 13C Nuclear Magnetic Resonance Spectroscopy". Proceedings of the National Academy of Sciences. 70 (12): 3531–3535. doi: 10.1073/pnas.70.12.3531 . PMC   427274 . PMID   4357878.
  12. De Dios, Angel C.; Pearson, John G.; Oldfield, Eric (1993). "Secondary and Tertiary Structural Effects on Protein NMR Chemical Shifts: an ab Initio Approach". Science. 260 (5113): 1491–1496. Bibcode:1993Sci...260.1491D. doi:10.1126/science.8502992. PMID   8502992.
  13. Wylie, Benjamin J.; Schwieters, Charles D.; Oldfield, Eric; Rienstra, Chad M. (January 28, 2009). "Protein Structure Refinement Using 13 Cα Chemical Shift Tensors". Journal of the American Chemical Society. 131 (3): 985–992. doi:10.1021/ja804041p. PMC   2751586 . PMID   19123862.
  14. Pearson, John G.; Oldfield, Eric; Lee, Frederick S.; Warshel, Arieh (1993). "Chemical shifts in proteins: a shielding trajectory analysis of the fluorine nuclear magnetic resonance spectrum of the Escherichia coli galactose binding protein using a multipole shielding polarizability-local reaction field-molecular dynamics approach". Journal of the American Chemical Society. 115 (15): 6851–6862. doi:10.1021/ja00068a049.
  15. Oldfield, Eric (2005). "Quantum chemical studies of protein structure". Philosophical Transactions of the Royal Society B: Biological Sciences. 360 (1458): 1347–1361. doi:10.1098/rstb.2003.1421. PMC   1569496 . PMID   16147526.
  16. Zhang, Yong; Mao, Junhong; Oldfield, Eric (2002). "57Fe Mössbauer Isomer Shifts of Heme Protein Model Systems: Electronic Structure Calculations". Journal of the American Chemical Society. 124 (26): 7829–7839. doi:10.1021/ja011583v. PMID   12083937.
  17. Zhang, Yong; Mao, Junhong; Godbout, Nathalie; Oldfield, Eric (2002). "Mössbauer Quadrupole Splittings and Electronic Structure in Heme Proteins and Model Systems: A Density Functional Theory Investigation". Journal of the American Chemical Society. 124 (46): 13921–13930. doi:10.1021/ja020298o. PMID   12431124.
  18. Mao, Junhong; Zhang, Yong; Oldfield, Eric (2002). "Nuclear Magnetic Resonance Shifts in Paramagnetic Metalloporphyrins and Metalloproteins". Journal of the American Chemical Society. 124 (46): 13911–13920. doi:10.1021/ja020297w. PMID   12431123.
  19. Arnold, William D.; Mao, Junhong; Sun, Haihong; Oldfield, Eric (2000). "Computation of Through-Space 19F−19F Scalar Couplings via Density Functional Theory". Journal of the American Chemical Society. 122 (49): 12164–12168. doi:10.1021/ja002361k.
  20. Arnold, William D.; Oldfield, Eric (2000). "The Chemical Nature of Hydrogen Bonding in Proteins via NMR: J-Couplings, Chemical Shifts, and AIM Theory". Journal of the American Chemical Society. 122 (51): 12835–12841. doi:10.1021/ja0025705.
  21. Ganapathy, Subramanian; Schramm, Suzanne; Oldfield, Eric (1982). "Variable-angle sample-spinning high resolution NMR of solids". The Journal of Chemical Physics. 77 (9): 4360–4365. doi:10.1063/1.444436.
  22. Kunwar, A.C; Turner, Gary L.; Oldfield, Eric (1986). "Solid-state spin-echo Fourier transform NMR of 39K and 67Zn salts at high field". Journal of Magnetic Resonance. 69: 124–127. doi:10.1016/0022-2364(86)90224-6.
  23. Oldfield, Eric; Timken, Hye Kyung C.; Montez, Ben; Ramachandran, R. (1985). "High-resolution solid-state NMR of quadrupolar nuclei". Nature. 318 (6042): 163–165. Bibcode:1985Natur.318..163O. doi:10.1038/318163a0. S2CID   4329616.
  24. "High-resolution silicon-29 nuclear magnetic resonance spectroscopic study of rock-forming silicates".
  25. Babu, P. K.; Oldfield, E.; Wieckowski, A. (March 17, 2003). Vayenas, C. G.; Conway, B. E.; White, Ralph E.; Gamboa-Adelco, Maria E. (eds.). Modern Aspects of Electrochemistry No. 36. Springer US. pp. 1–50. doi:10.1007/0-306-47927-3_1 via Springer Link.
  26. Urbina, Julio A.; Moreno, Benjamin; Vierkotter, Stephanie; Oldfield, Eric; Payares, Gilberto; Sanoja, Cristina; Bailey, Brian N.; Yan, Wen; Scott, David A.; Moreno, Silvia N. J.; Docampo, Roberto (November 19, 1999). "Trypanosoma cruzi Contains Major Pyrophosphate Stores, and Its Growth in Vitro and in Vivo Is Blocked by Pyrophosphate Analogs *". Journal of Biological Chemistry. 274 (47): 33609–33615. doi: 10.1074/jbc.274.47.33609 . PMID   10559249 via www.jbc.org.
  27. Martin, Michael B.; Grimley, Joshua S.; Lewis, Jared C.; Heath, Huel T.; Bailey, Brian N.; Kendrick, Howard; Yardley, Vanessa; Caldera, Aura; Lira, Renee; Urbina, Julio A.; Moreno, Silvia N. J.; Docampo, Roberto; Croft, Simon L.; Oldfield, Eric (March 1, 2001). "Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania d onovani, Toxoplasma g ondii, and Plasmodium f alciparum : A Potential Route to Chemotherapy". Journal of Medicinal Chemistry. 44 (6): 909–916. doi:10.1021/jm0002578. PMID   11300872.
  28. "Radical Cure of Experimental Cutaneous Leishmaniasis by the Bisphosphonate Pamidronate".
  29. Martin, Michael B.; Arnold, William; Heath, Huel T.; Urbina, Julio A.; Oldfield, Eric (1999). "Nitrogen-Containing Bisphosphonates as Carbocation Transition State Analogs for Isoprenoid Biosynthesis". Biochemical and Biophysical Research Communications. 263 (3): 754–758. doi:10.1006/bbrc.1999.1404. PMID   10512752.
  30. Benaim, Gustavo; Sanders, John M.; Garcia-Marchán, Yael; Colina, Claudia; Lira, Renee; Caldera, Aura R.; Payares, Gilberto; Sanoja, Cristina; Burgos, Juan Miguel; Leon-Rossell, Annette; Concepcion, Juan Luis; Schijman, Alejandro G.; Levin, Mariano; Oldfield, Eric; Urbina, Julio A. (2006). "Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with posaconazole†". Journal of Medicinal Chemistry. 49 (3): 892–899. doi:10.1021/jm050691f. hdl: 11336/79898 . PMID   16451055.
  31. "Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity".
  32. Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric (2008). "A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence". Science. 319 (5868): 1391–1394. Bibcode:2008Sci...319.1391L. doi:10.1126/science.1153018. PMC   2747771 . PMID   18276850.
  33. Li, Kai; Schurig-Briccio, Lici A.; Feng, Xinxin; Upadhyay, Ashutosh; Pujari, Venugopal; Lechartier, Benoit; Fontes, Fabio L.; Yang, Hongliang; Rao, Guodong; Zhu, Wei; Gulati, Anmol; No, Joo Hwan; Cintra, Giovana; Bogue, Shannon; Liu, Yi-Liang; Molohon, Katie; Orlean, Peter; Mitchell, Douglas A.; Freitas-Junior, Lucio; Ren, Feifei; Sun, Hong; Jiang, Tong; Li, Yujie; Guo, Rey-Ting; Cole, Stewart T.; Gennis, Robert B.; Crick, Dean C.; Oldfield, Eric (April 10, 2014). "Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases". Journal of Medicinal Chemistry. 57 (7): 3126–3139. doi:10.1021/jm500131s. PMC   4084622 . PMID   24568559.
  34. No, Joo Hwan; De Macedo Dossin, Fernando; Zhang, Yonghui; Liu, Yi-Liang; Zhu, Wei; Feng, Xinxin; Yoo, Jinyoung Anny; Lee, Eunhae; Wang, Ke; Hui, Raymond; Freitas-Junior, Lucio H.; Oldfield, Eric (2012). "Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity". Proceedings of the National Academy of Sciences. 109 (11): 4058–4063. Bibcode:2012PNAS..109.4058N. doi: 10.1073/pnas.1118215109 . PMC   3306666 . PMID   22392982. S2CID   10108911.
  35. Xia, Yifeng; Liu, Yi-Liang; Xie, Yonghua; Zhu, Wei; Guerra, Francisco; Shen, Shen; Yeddula, Narayana; Fischer, Wolfgang; Low, William; Zhou, Xiaoying; Zhang, Yonghui; Oldfield, Eric; Verma, Inder M. (2014). "A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin". Science Translational Medicine. 6 (263): 263ra161. doi:10.1126/scitranslmed.3010382. PMC   4326221 . PMID   25411474.
  36. Xia, Yun; Xie, Yonghua; Yu, Zhengsen; Xiao, Hongying; Jiang, Guimei; Zhou, Xiaoying; Yang, Yunyun; Li, Xin; Zhao, Meng; Li, Liping; Zheng, Mingke; Han, Shuai; Zong, Zhaoyun; Meng, Xianbin; Deng, Haiteng; Ye, Huahu; Fa, Yunzhi; Wu, Haitao; Oldfield, Eric; Hu, Xiaoyu; Liu, Wanli; Shi, Yan; Zhang, Yonghui (2018). "The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery". Cell. 175 (4): 1059–1073.e21. doi: 10.1016/j.cell.2018.08.070 . PMID   30270039.
  37. Yuan, Linjie; Ma, Xianqiang; Yang, Yunyun; Li, Xin; Ma, Weiwei; Yang, Haoyu; Huang, Jian-Wen; Xue, Jing; Yi, Simin; Zhang, Mengting; Cai, Ningning; Ding, Qingyang; Li, Liping; Duan, Jianxin; Malwal, Satish; Chen, Chun-Chi; Oldfield, Eric; Guo, Rey-Ting; Zhang, Yonghui (2022). "Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation". doi:10.1101/2022.01.02.474068. S2CID   245705122.{{cite journal}}: Cite journal requires |journal= (help)
  38. Zhou, Xiaoying; Gu, Yanzheng; Xiao, Hongying; Kang, Ning; Xie, Yonghua; Zhang, Guangbo; Shi, Yan; Hu, Xiaoyu; Oldfield, Eric; Zhang, Xueguang; Zhang, Yonghui (2017). "Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells". Frontiers in Immunology. 8: 1381. doi: 10.3389/fimmu.2017.01381 . PMC   5661056 . PMID   29118758.
  39. Malwal, Satish R.; o'Dowd, Bing; Feng, Xinxin; Turhanen, Petri; Shin, Christopher; Yao, Jiaqi; Kim, Boo Kyung; Baig, Noman; Zhou, Tianhui; Bansal, Sandhya; Khade, Rahul L.; Zhang, Yong; Oldfield, Eric (2018). "Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways". Journal of the American Chemical Society. 140 (24): 7568–7578. doi:10.1021/jacs.8b02363. PMC   6022752 . PMID   29787268.
  40. Oldfield, Eric; Lin, Fu-Yang (2012). "Terpene Biosynthesis: Modularity Rules". Angewandte Chemie International Edition. 51 (5): 1124–1137. doi:10.1002/anie.201103110. PMC   3769779 . PMID   22105807.
  41. Cao, Rong; Zhang, Yonghui; Mann, Francis M.; Huang, Cancan; Mukkamala, Dushyant; Hudock, Michael P.; Mead, Matthew E.; Prisic, Sladjana; Wang, Ke; Lin, Fu-Yang; Chang, Ting-Kai; Peters, Reuben J.; Oldfield, Eric (2010). "Diterpene cyclases and the nature of the isoprene fold". Proteins: Structure, Function, and Bioinformatics. 78 (11): 2417–2432. doi:10.1002/prot.22751. PMC   3805035 . PMID   20602361.
  42. Wang, Weixue; Oldfield, Eric (2014). "Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis". Angewandte Chemie International Edition. 53 (17): 4294–4310. doi:10.1002/anie.201306712. PMC   3997630 . PMID   24481599.
  43. Chen, Chun-Chi; Malwal, Satish R.; Han, Xu; Liu, Weidong; Ma, Lixin; Zhai, Chao; Dai, Longhai; Huang, Jian-Wen; Shillo, Alli; Desai, Janish; Ma, Xianqiang; Zhang, Yonghui; Guo, Rey-Ting; Oldfield, Eric (2021). "Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action". ACS Catalysis. 11: 290–303. doi:10.1021/acscatal.0c04710. S2CID   230567887.
  44. "RSC Awards Archive – Meldola Medal and Prize". www.rsc.org.
  45. "The Colworth Medal". www.biochemistry.org.
  46. "Past Recipients". American Chemical Society.
  47. "Soft Matter and Biophysical Chemistry Award". Royal Society of Chemistry.
  48. "Society Awards – The Biophysical Society". www.biophysics.org.