A carcinogen is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruses and bacteria. Most carcinogens act by creating mutations in DNA that disrupt a cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells. The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division.
Fiberglass or fibreglass is a common type of fiber-reinforced plastic using glass fiber. The fibers may be randomly arranged, flattened into a sheet called a chopped strand mat, or woven into glass cloth. The plastic matrix may be a thermoset polymer matrix—most often based on thermosetting polymers such as epoxy, polyester resin, or vinyl ester resin—or a thermoplastic.
Mineral wool is any fibrous material formed by spinning or drawing molten mineral or rock materials such as slag and ceramics.
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs. The area most commonly affected is the lining of the lungs and chest wall. Less commonly the lining of the abdomen and rarely the sac surrounding the heart, or the sac surrounding the testis may be affected. Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss. These symptoms typically come on slowly.
Asbestosis is long-term inflammation and scarring of the lungs due to asbestos fibers. Symptoms may include shortness of breath, cough, wheezing, and chest tightness. Complications may include lung cancer, mesothelioma, and pulmonary heart disease.
Chrysotile or white asbestos is the most commonly encountered form of asbestos, accounting for approximately 95% of the asbestos in the United States and a similar proportion in other countries. It is a soft, fibrous silicate mineral in the serpentine subgroup of phyllosilicates; as such, it is distinct from other asbestiform minerals in the amphibole group. Its idealized chemical formula is Mg3(Si2O5)(OH)4. The material has physical properties which make it desirable for inclusion in building materials, but poses serious health risks when dispersed into air and inhaled.
Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. It is marked by inflammation and scarring in the form of nodular lesions in the upper lobes of the lungs. It is a type of pneumoconiosis. Silicosis, particularly the acute form, is characterized by shortness of breath, cough, fever, and cyanosis. It may often be misdiagnosed as pulmonary edema, pneumonia, or tuberculosis. Using workplace controls, silicosis is almost always a preventable disease.
Tremolite is a member of the amphibole group of silicate minerals with composition Ca2(Mg5.0-4.5Fe2+0.0-0.5)Si8O22(OH)2. Tremolite forms by metamorphism of sediments rich in dolomite and quartz, and occurs in two distinct forms, crystals and fibers. Tremolite forms a series with actinolite and ferro-actinolite. Pure magnesium tremolite is creamy white, but the color grades to dark green with increasing iron content. It has a hardness on Mohs scale of 5 to 6. Nephrite, one of the two minerals known as the gemstone jade, is a green crystalline variety of tremolite.
Glass wool is an insulating material made from glass fiber arranged using a binder into a texture similar to wool. The process traps many small pockets of air between the glass, and these small air pockets result in high thermal insulation properties. Glass wool is produced in rolls or in slabs, with different thermal and mechanical properties. It may also be produced as a material that can be sprayed or applied in place, on the surface to be insulated. The modern method for producing glass wool was invented by Games Slayter while he was working at the Owens-Illinois Glass Co.. He first applied for a patent for a new process to make glass wool in 1933.
The mineral asbestos is subject to a wide range of laws and regulations that relate to its production and use, including mining, manufacturing, use and disposal. Injuries attributed to asbestos have resulted in both workers' compensation claims and injury litigation. Health problems attributed to asbestos include asbestosis, mesothelioma, lung cancer, and diffuse pleural thickening.
IARC group 1 Carcinogens are substances, chemical mixtures, and exposure circumstances which have been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent may be placed in this category when evidence of carcinogenicity in humans is less than sufficient, but when there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity.
Occupational lung diseases comprise a broad group of diseases, including occupational asthma, industrial bronchitis, chronic obstructive pulmonary disease (COPD), bronchiolitis obliterans, inhalation injury, interstitial lung diseases, infections, lung cancer and mesothelioma. These can be caused directly or due to immunological response to an exposure to a variety of dusts, chemicals, proteins or organisms. Occupational cases of interstitial lung disease may be misdiagnosed as COPD, idiopathic pulmonary fibrosis, or a myriad of other diseases; leading to a delay in identification of the causative agent.
In construction, asbestos abatement is a set of procedures designed to control the release of asbestos fibers from asbestos-containing materials. Asbestos abatement is utilized during general construction in areas containing asbestos materials, particularly when those materials are being removed, encapsulated, or repaired. Abatement is needed in order to protect construction workers and members of the general public from the many negative health impacts of asbestos.
Asbestos is a naturally occurring fibrous silicate mineral. There are six types, all of which are composed of long and thin fibrous crystals, each fibre being composed of many microscopic "fibrils" that can be released into the atmosphere by abrasion and other processes. Inhalation of asbestos fibres can lead to various dangerous lung conditions, including mesothelioma, asbestosis, and lung cancer. As a result of these health effects, asbestos is considered a serious health and safety hazard.
Peritoneal mesothelioma is the name given to the cancer that attacks the lining of the abdomen. This type of cancer affects the lining that protects the contents of the abdomen and which also provides a lubricating fluid to enable the organs to move and work properly.
Asbestos-related diseases are disorders of the lung and pleura caused by the inhalation of asbestos fibres. Asbestos-related diseases include non-malignant disorders such as asbestosis, diffuse pleural thickening, pleural plaques, pleural effusion, rounded atelectasis and malignancies such as lung cancer and malignant mesothelioma.
Metsovo lung was an epidemic of lung disease resulting from domestic exposure to asbestos in the village of Metsovo in northwest Greece. Most of the inhabitants had previously been exposed to a whitewash derived from local soils containing tremolite asbestos. This caused an epidemic of malignant mesothelioma (MM) that reached an incidence 300 times that expected in populations not exposed to asbestos. This was accompanied by pleural calcifications (PCs) in almost half the adult population. Both conditions have declined significantly since the whitewash ceased to be used after 1985.
Toxicology of carbon nanomaterials is the study of toxicity in carbon nanomaterials like fullerenes and carbon nanotubes.
All types of asbestos fibers are known to cause serious health hazards in humans. The most common diseases associated with chronic exposure to asbestos are asbestosis and mesothelioma.
Occupational hazards of fire debris cleanup are the hazards to health and safety of the personnel tasked with clearing the area of debris and combustion products after a conflagration. Once extinguished, fire debris cleanup poses several safety and health risks for workers. Employers responsible for fire debris cleanup and other work in areas damaged or destroyed by fire are generally obliged by occupational safety and health legislation of the relevant national or regional authority to identify and evaluate hazards, correct any unsafe or unhealthy conditions and provide any necessary training and instruction and personal protective equipment to employees to enable them to carry out the task without undue exposure to hazards. Many of the approaches to control risk in occupational settings can be applied to preventing injuries and disease. This type of work can be completed by general construction firms who may not be fully trained specifically for fire safety and on fire hazards.
