Exosome component 2

EXOSC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC2 , RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF
External IDs	OMIM: 602238; MGI: 2385133; HomoloGene: 6095; GeneCards: EXOSC2; OMA:EXOSC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.12 Start 130,693,721 bp [1] End 130,707,288 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 31,560,727 bp [2] End 31,571,361 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad Achilles tendon cerebellar hemisphere left ovary granulocyte right hemisphere of cerebellum right ovary rectum Top expressed in embryo molar epiblast blastocyst yolk sac embryo morula somite ventricular zone neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5'-exoribonuclease activity exoribonuclease activity 7S RNA binding protein binding RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleus nucleoplasm nucleolus Biological process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent rRNA catabolic process regulation of mRNA stability exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' CUT catabolic process positive regulation of cell growth exonucleolytic catabolism of deadenylated mRNA rRNA processing U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23404 227715 Ensembl ENSG00000130713 ENSMUSG00000039356 UniProt Q13868 Q8VBV3 RefSeq (mRNA) NM_001282708 NM_001282709 NM_014285 NM_144886 RefSeq (protein) NP_001269637 NP_001269638 NP_055100 NP_659135 Location (UCSC) Chr 9: 130.69 – 130.71 Mb Chr 2: 31.56 – 31.57 Mb PubMed search [3] [4]
Wikidata
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Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. ^{[5] [6]}

Function

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome. ^[7]

Interactions

Exosome component 2 has been shown to interact with:

• Exosome component 4, ^[8] and
• Exosome component 7. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000130713 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039356 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EXOSC2 exosome component 2".
6. Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D (November 1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4): 457–66. doi: 10.1016/S0092-8674(00)80432-8 . PMID   9390555. S2CID   16035676.
7. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi: 10.1016/S0092-8674(01)00578-5 . PMID   11719186. S2CID   14817671.
8. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. hdl: 2066/186665 . PMID   12419256.

Further reading

• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID   1538749. S2CID   4234345.
• Morris CM, Heisterkamp N, Groffen J, Fitzgerald PH (1991). "Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia". Blood. 78 (4): 1078–84. doi: 10.1182/blood.V78.4.1078.1078 . PMID   1868241.
• Zhu QS, Heisterkamp N, Groffen J (1990). "Characterization of the human ABL promoter regions". Oncogene. 5 (6): 885–91. PMID   2163052.
• Soekarman D, van Denderen J, Hoefsloot L, et al. (1990). "A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia". Leukemia. 4 (6): 397–403. PMID   2193202.
• Chen SJ, Chen Z, Font MP, et al. (1989). "Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation". Nucleic Acids Res. 17 (19): 7631–42. doi:10.1093/nar/17.19.7631. PMC   334872 . PMID   2678002.
• Heisterkamp N, Stam K, Groffen J, et al. (1985). "Structural organization of the bcr gene and its role in the Ph' translocation". Nature. 315 (6022): 758–61. Bibcode:1985Natur.315..758H. doi:10.1038/315758a0. PMID   2989703. S2CID   4343076.
• Shtivelman E, Lifshitz B, Gale RP, et al. (1986). "Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene". Cell. 47 (2): 277–84. doi:10.1016/0092-8674(86)90450-2. PMID   3021337. S2CID   36324337.
• Grosveld G, Verwoerd T, van Agthoven T, et al. (1987). "The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript". Mol. Cell. Biol. 6 (2): 607–16. doi:10.1128/mcb.6.2.607. PMC   367552 . PMID   3023859.
• Bernards A, Rubin CM, Westbrook CA, et al. (1987). "The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia". Mol. Cell. Biol. 7 (9): 3231–6. doi:10.1128/mcb.7.9.3231. PMC   367959 . PMID   3313010.
• Groffen J, Heisterkamp N, Grosveld F, et al. (1982). "Isolation of human oncogene sequences (v-fes homolog) from a cosmid library". Science. 216 (4550): 1136–8. Bibcode:1982Sci...216.1136G. doi:10.1126/science.6281890. PMID   6281890.
• Heisterkamp N, Groffen J, Stephenson JR (1983). "The human v-abl cellular homologue". J. Mol. Appl. Genet. 2 (1): 57–68. PMID   6302194.
• Heisterkamp N, Stephenson JR, Groffen J, et al. (1984). "Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia". Nature. 306 (5940): 239–42. doi:10.1038/306239a0. PMID   6316147. S2CID   4258884.
• Groffen J, Stephenson JR, Heisterkamp N, et al. (1984). "Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22". Cell. 36 (1): 93–9. doi:10.1016/0092-8674(84)90077-1. PMID   6319012. S2CID   9876892.
• Chissoe SL, Bodenteich A, Wang YF, et al. (1995). "Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID   7665185.
• Litz CE, McClure JS, Copenhaver CM, Brunning RD (1993). "Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia". Blood. 81 (6): 1567–72. doi: 10.1182/blood.V81.6.1567.1567 . PMID   8453102.
• Mitchell P, Petfalski E, Tollervey D (1996). "The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism". Genes Dev. 10 (4): 502–13. doi: 10.1101/gad.10.4.502 . PMID   8600032.
• Mitchell P, Petfalski E, Shevchenko A, et al. (1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4): 457–66. doi: 10.1016/S0092-8674(00)80432-8 . PMID   9390555. S2CID   16035676.
• Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC   316947 . PMID   10465791.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi: 10.1074/jbc.M007603200 . hdl: 2066/186951 . PMID   11110791.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi: 10.1016/S0092-8674(01)00578-5 . PMID   11719186. S2CID   14817671.