Exosome component 7

EXOSC7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC7 , EAP1, RRP42, Rrp42p, hRrp42p, p8, Exosome component 7
External IDs	OMIM: 606488 MGI: 1913696 HomoloGene: 8994 GeneCards: EXOSC7
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,036,066 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	122,965,194 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; thoracic diaphragm; ; right adrenal gland; ; left adrenal gland; ; skin of abdomen; ; body of tongue; ; nipple; ; triceps brachii muscle; ; gastrocnemius muscle;
	Top expressed in
	otic placode; ; morula; ; saccule; ; primitive streak; ; yolk sac; ; somite; ; blastocyst; ; endocardial cushion; ; right lung lobe; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity ; exoribonuclease activity ; protein binding ; RNA binding ;
Cellular component	cytoplasm ; cytosol ; exosome (RNase complex) ; nucleolus ; nucleoplasm ; nucleus ; nuclear exosome (RNase complex) ; cytoplasmic exosome (RNase complex) ;
Biological process	regulation of mRNA stability ; RNA catabolic process ; rRNA processing ; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' ; U1 snRNA 3'-end processing ; U4 snRNA 3'-end processing ; U5 snRNA 3'-end processing ; exonucleolytic catabolism of deadenylated mRNA ; nuclear mRNA surveillance ; nuclear polyadenylation-dependent rRNA catabolic process ; nuclear polyadenylation-dependent tRNA catabolic process ; nuclear polyadenylation-dependent mRNA catabolic process ; rRNA catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	23016
	66446
	ENSG00000075914
	ENSMUSG00000025785
	Q15024
	Q9D0M0
	NM_015004
	NM_001081188 ; NM_025568
	NP_055819
	NP_001074657
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 30, 2024

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.^[5]

Interactions

Exosome component 7 has been shown to interact with:

Related Research Articles

The exosome complex is a multi-protein intracellular complex capable of degrading various types of RNA molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions.

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.

Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.

Ribonuclease P protein subunit p20 is an enzyme that in humans is encoded by the POP7 gene.

Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene.

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.

Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex.

Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.

Superkiller viralicidic activity 2-like 2 is a protein that in humans is encoded by the SKIV2L2 gene.

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.

Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.

RNA component of mitochondrial RNA processing endoribonuclease, also known as RMRP, is a human gene.

Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene. The C1D protein is encoded by a DNA binding gene traced in the nucleus. Protein C1D has a chromosomal location of 2p14. C1D has a family of proteins consisting of C1D homologues which may include Sas10 domains. C1D is thought to bind to RNA and DNA where it may be involved in mechanisms of DNA repair. Protein C1D is ubiquitously expressed in different human tissues.

U3 small nucleolar RNA-interacting protein 2 is a protein that in humans is encoded by the RRP9 gene.

Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene.

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000075914 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025785 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EXOSC7 exosome component 7".
1 2 3 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. hdl: 2066/186665 . PMID 12419256.
↑ Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl: 2066/261980 . PMID 11812149.

Butler JS (2002). "The yin and yang of the exosome". Trends Cell Biol. 12 (2): 90–6. doi:10.1016/S0962-8924(01)02225-5. PMID 11849973.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID 7788527.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi: 10.1074/jbc.M007603200 . hdl: 2066/186951 . PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi: 10.1016/S0092-8674(01)00578-5 . PMID 11719186. S2CID 14817671.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl: 2066/261980 . PMID 11812149.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi: 10.1186/ar389 . PMC 83843 . PMID 11879549.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl: 2066/186665 . PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000075914 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025785 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EXOSC7 exosome component 7".

[pmid12419256-6] 1 2 3 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. hdl: 2066/186665 . PMID 12419256.

[pmid11812149-7] Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl: 2066/261980 . PMID 11812149.

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Exosome component 7

Contents

Interactions

Related Research Articles

References

Further reading