Exosome component 6

EXOSC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC6 , EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490 MGI: 1919794 HomoloGene: 12469 GeneCards: EXOSC6
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 70,246,778 bp [1] End 70,251,940 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 111,782,971 bp [2] End 111,784,296 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 postcentral gyrus Brodmann area 46 superior frontal gyrus middle temporal gyrus Achilles tendon entorhinal cortex pons external globus pallidus Top expressed in embryo morula vasculature temporal lobe amygdala spinal cord brain stem choroid plexus meninges bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function exoribonuclease activity RNA binding Cellular component cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) nucleolus nucleus nucleoplasm Biological process regulation of mRNA stability nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' rRNA 3'-end processing rRNA catabolic process DNA deamination nuclear mRNA surveillance exonucleolytic catabolism of deadenylated mRNA U4 snRNA 3'-end processing polyadenylation-dependent snoRNA 3'-end processing rRNA processing positive regulation of isotype switching isotype switching RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 118460 72544 Ensembl ENSG00000223496 ENSMUSG00000109941 UniProt Q5RKV6 Q8BTW3 RefSeq (mRNA) NM_058219 NM_028274 RefSeq (protein) NP_478126 NP_082550 Location (UCSC) Chr 16: 70.25 – 70.25 Mb Chr 8: 111.78 – 111.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene. ^{[5] [6] [7]}

This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. ^[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7, ^[6] Exosome component 8 ^[6] and Exosome component 1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000223496 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000109941 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi: 10.1016/S0092-8674(01)00578-5 . PMID   11719186. S2CID   14817671.
6. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. hdl: 2066/186665 . PMID   12419256.
7. "Entrez Gene: EXOSC6 exosome component 6".

Further reading

• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• van Hoof A, Parker R (2002). "Messenger RNA degradation: beginning at the end". Curr. Biol. 12 (8): R285–7. Bibcode:2002CBio...12.R285V. doi: 10.1016/S0960-9822(02)00802-3 . PMID   11967169. S2CID   17142692.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. hdl: 2066/261980 . PMID   11812149.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi: 10.1074/jbc.M007603200 . hdl: 2066/186951 . PMID   11110791.