FANCD2OS

FANCD2OS
Identifiers
Aliases	FANCD2OS , C3orf24, FANCD2 opposite strand
External IDs	MGI: 1918229; HomoloGene: 45456; GeneCards: FANCD2OS; OMA:FANCD2OS - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.3 Start 10,081,317 bp [1] End 10,108,255 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 E3 Start 113,573,722 bp [2] End 113,577,676 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis pancreatic ductal cell sperm testicle gonad muscle tissue granulocyte minor salivary glands gastric mucosa Top expressed in seminiferous tubule spermatid proximal tubule morula embryo right kidney human kidney spermatocyte blastocyst blastocyst More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 115795 70979 Ensembl ENSG00000163705 ENSMUSG00000033963 UniProt Q96PS1 Q9D4K4 RefSeq (mRNA) NM_173472 NM_001164839 NM_027633 RefSeq (protein) NP_001158311 NP_775743 NP_081909 Location (UCSC) Chr 3: 10.08 – 10.11 Mb Chr 6: 113.57 – 113.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene. ^[5] The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

Gene

The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length. ^[6] The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes. ^[5]

mRNA

There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage. ^[7] The most common isoform is 1105 bp. ^[8]

Promoter Region

The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

Regulatory

Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

Expression

FANCD2OS is moderately expressed in the human brain, placenta and testes. ^[9]

Evolutionary History

Protein sequence

The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily. ^[10]

Orthologs

Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark. ^[11] The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

Species	Common name	NCBI accession	Identity	similarity	E-value
Pongo abelii	Sumatran orangutan	XP_003776240.1	98.9	99.4	1.21E-133
Cricetulus griseus	Chinese hamster	XP_003511850.1	73.6	80.9	1.56E-95
Ovis aries	Sheep	XP_004018322.1	97.2	98.3	6.79E-131
Leptonychotes weddellii	Weddell seal	XP_006739055.1	96.6	98.3	5.13E-130
Condylura cristata	Star-nosed mole	XP_004692437.1	91.0	95.5	3.01E-123
Orcinus orca	Killer whale	XP_004286877.2	88.1	92.3	1.05E-90
Trichechus manatus latirostris	Florida manatee	XP_004368376.1	96.6	98.9	9.95E-131
Alligator mississippiensis	American alligator	XP_014457972.1	69.3	88.6	1.40E-48
Chrysemys picta bellii	Painted turtle	XP_005307285.1	58.3	75	2.18E-78
Gekko japonicus	Schlegel's Japanese gecko	XP_015261231.1	56.5	72.3	4.39E-74
Thamnophis sirtalis	Common garter snake	XP_013914711.1	55.9	69.5	2.75E-69
Xenopus laevis	African clawed frog	NP_001088778.1	55.4	71.2	1.98E-68
Xenopus tropicalis	Western clawed frog	NP_001090717.1	52	71.2	3.57E-65
Callorhinchus milii	Australian ghostshark	XP_007888744.1	39.9	56.8	5.67E-43

Paralogs

FANCD2OS has no known paralogs in Homo sapiens.

References

^{[6] [5] [11] [7] [10] [9]}

1. GRCh38: Ensembl release 89: ENSG00000163705 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033963 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene - FANCD2OS FANCD2 opposite strand Homo sapiens" . Retrieved 6 February 2016.
6. "FANCD2 opposite strand protein". NCBI. Retrieved 2 May 2016.
7. "AceView C3orf24". NCBI. Retrieved 2 May 2016.
8. "Homo sapiens FANCD2 opposite strand (FANCD2OS), transcript variant 1, mRNA". NCBI Nucleotide. NCBI. Retrieved 19 April 2016.
9. "NCBI - GDS592 / gnf1m17159_at / Fancd2os". NCBI. Retrieved 15 Mar 2016.
10. "Conserved Protein Domain Family DUF4563". NCBI. Retrieved 2 May 2016.
11. "Homologene: FANCD2OS". Archived from the original on December 14, 2024. Retrieved 6 February 2016.