The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency under the Department of Health and Human Services, and is headquartered in Atlanta, Georgia.
The Vaccine Adverse Event Reporting System (VAERS) is a United States program for vaccine safety, co-managed by the U.S. Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA). VAERS is a postmarketing surveillance program, collecting information about adverse events that occur after administration of vaccines to ascertain whether the risk–benefit ratio is high enough to justify continued use of any particular vaccine.
The Biomedical Advanced Research and Development Authority (BARDA) is a U.S. Department of Health and Human Services (HHS) office responsible for the procurement and development of medical countermeasures, principally against bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats, as well as pandemic influenza and emerging diseases. BARDA was established in 2006 through the Pandemic and All-Hazards Preparedness Act (PAHPA) and reports to the Office of the Assistant Secretary for Preparedness and Response (ASPR). The office manages Project BioShield, which funds the research, development and stockpiling of vaccines and treatments that the government could use during public health emergencies such as chemical, biological, radiological or nuclear (CBRN) attacks.
The Administration for Strategic Preparedness and Response (ASPR) is an operating agency of the U.S. Public Health Service within the Department of Health and Human Services that focuses on preventing, preparing for, and responding to the adverse health effects of public health emergencies and disasters. Its functions include preparedness planning and response; building federal emergency medical operational capabilities; countermeasures research, advance development, and procurement; and grants to strengthen the capabilities of hospitals and health care systems in public health emergencies and medical disasters. The office provides federal support, including medical professionals through ASPR’s National Disaster Medical System, to augment state and local capabilities during an emergency or disaster.
An Emergency Use Authorization (EUA) in the United States is an authorization granted to the Food and Drug Administration (FDA) under sections of the Federal Food, Drug, and Cosmetic Act as added to and amended by various Acts of Congress, including by the Pandemic and All-Hazards Preparedness Reauthorization Act of 2013 (PAHPRA), as codified by 21 U.S.C. § 360bbb-3, to allow the use of a drug prior to approval. It does not constitute approval of the drug in the full statutory meaning of the term, but instead authorizes the FDA to facilitate availability of an unapproved product, or an unapproved use of an approved product, during a declared state of emergency from one of several agencies or of a "material threat" by the Secretary of Homeland Security.
Measles was declared eliminated from the United States in 2000 by the World Health Organization due to the success of vaccination efforts. However, it continues to be reintroduced by international travelers, and in recent years, anti-vaccination sentiment has allowed for the reemergence of measles outbreaks.
On December 31, 2019, China announced the discovery of a cluster of pneumonia cases in Wuhan. The first American case was reported on January 20, and Health and Human Services Secretary Alex Azar declared a public health emergency on January 31. Restrictions were placed on flights arriving from China, but the initial U.S. response to the pandemic was otherwise slow in terms of preparing the healthcare system, stopping other travel, and testing. The first known American deaths occurred in February and in late February President Donald Trump proposed allocating $2.5 billion to fight the outbreak. Instead, Congress approved $8.3 billion with only Senator Rand Paul and two House representatives voting against, and Trump signed the bill, the Coronavirus Preparedness and Response Supplemental Appropriations Act, 2020, on March 6. Trump declared a national emergency on March 13. The government also purchased large quantities of medical equipment, invoking the Defense Production Act of 1950 to assist. By mid-April, disaster declarations were made by all states and territories as they all had increasing cases. A second wave of infections began in June, following relaxed restrictions in several states, leading to daily cases surpassing 60,000. By mid-October, a third surge of cases began; there were over 200,000 new daily cases during parts of December 2020 and January 2021.
A COVID‑19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID‑19).
The Moderna COVID‑19 vaccine, sold under the brand name Spikevax, is a COVID-19 vaccine developed by the American company Moderna, the United States National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA). Depending on the jurisdiction, it is authorized for use in humans aged six months, twelve years, or eighteen years and older. It provides protection against COVID-19, which is caused by infection by the SARS-CoV-2 virus.
The Africa Centres for Disease Control and Prevention is a public health agency of the African Union to support the public health initiatives of member states and strengthen the capacity of their health institutions to deal with disease threats. The idea of an African CDC was proposed by the government of Ethiopia in 2013, during a TB/HIV special summit in Abuja, Nigeria. From 2013 to 2016, the modalities and statute of Africa CDC were developed, and the specialized agency was officially launched in January 2017.
The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the American company Pfizer to carry out clinical trials, logistics, and manufacturing. It is authorized for use in humans to provide protection against COVID-19, caused by infection with the SARS-CoV-2 virus. The vaccine is given by intramuscular injection. It is composed of nucleoside-modified mRNA (modRNA) that encodes a mutated form of the full-length spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles. Initial guidance recommended a two-dose regimen, given 21 days apart; this interval was subsequently extended to up to 42 days in the United States, and up to four months in Canada.
Rochelle Paula Walensky is an American physician-scientist who served as the director of the U.S. Centers for Disease Control and Prevention from 2021 to 2023 and served as the administrator of the Agency for Toxic Substances and Disease Registry in her capacity as the director of the U.S. Centers for Disease Control and Prevention from 2021 to 2023. On May 5, 2023, she announced her resignation, effective June 30, 2023. Prior to her appointment at the CDC, she had served as the chief of the Division of Infectious Diseases at Massachusetts General Hospital and a professor of medicine at Harvard Medical School. Walensky is an expert on HIV/AIDS.
The Janssen COVID‑19 vaccine, (Ad26.COV2.S) sold under the brand name Jcovden, is a COVID‑19 vaccine that was developed by Janssen Vaccines in Leiden, Netherlands, and its Belgian parent company Janssen Pharmaceuticals, a subsidiary of American company Johnson & Johnson.
Nirav Dinesh Shah is an American epidemiologist, economist and attorney. He worked as an economist and epidemiologist at the Cambodian Ministry of Health. Shah was appointed as the director of the Illinois Department of Public Health in 2015 and served in that role until 2019. He served as the director of the Maine Center for Disease Control and Prevention from 2019 to 2023. In January 2023, he was appointed as the principal deputy director of the U.S. Centers for Disease Control and Prevention and he assumed that position in March 2023. Following the resignation of Rochelle Walensky, Shah served as the acting director of the U.S. Centers for Disease Control and Prevention in July 2023 until Mandy Cohen assumed office.
In many countries, the dissemination of varied claims and perspectives regarding COVID-19 vaccines has sparked widespread public discussion. These include concerns about potential side effects, differing interpretations of how the immune system responds to vaccination, and debates over the development and distribution of COVID-19 vaccines. Additionally, stories such as COVID-19 being linked to 5G technology and other debated information have also emerged. This spread of information, including content from anti-vaccination advocates, may have influenced people's attitudes towards vaccination. In response, governments and private organizations around the world have introduced measures to encourage or mandate vaccination, such as lotteries, mandates, and free entry to events. These measures have further fueled debates about their legality and effectiveness.
Joseph Abiodun Ladapo is a Nigerian-American doctor serving as the surgeon general of Florida since 2021. He is best known for his opposition to COVID-19 mitigation measures, and promotion of COVID-19 misinformation, for which he has been rebuked by the Centers for Disease Control and Prevention. Ladapo has promoted unproven treatments, opposed vaccine and mask mandates, questioned the safety of COVID-19 vaccines, and contradicted professional medical organizations.
Brian King is an American Epidemiologist who currently serves as the Director of the Food and Drug Administration's Center for Tobacco Products (CTP). He was appointed to his role in July 2022.
Since 1980, the U.S. Centers for Disease Control and Prevention has been organized around constituent centers, institutes, and offices (CIOs). Five centers were created in 1980, from which the current centers are descended, with the exception of the National Institute for Occupational Safety and Health and National Center for Health Statistics, which were absorbed from outside CDC.
Turbo cancer is an anti-vaccination conspiracy theory alleging that people vaccinated against COVID-19, especially with mRNA vaccines, are suffering from a high incidence of fast-developing cancers. Although the idea has been spread by a number of vaccine opponents, including several health professionals, turbo cancer is not supported by cancer research, and there is no evidence that COVID-19 vaccination causes or worsens cancer.
Melinda Wharton is an American epidemiologist. She was acting director for the Immunization Division in the Centers for Disease Control.
