GABARAPL2

GABARAPL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CO7
Identifiers
Aliases	GABARAPL2 , ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, GABA type A receptor associated protein like 2
External IDs	OMIM: 607452; MGI: 1890602; HomoloGene: 68550; GeneCards: GABARAPL2; OMA:GABARAPL2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q23.1 Start 75,566,375 bp [1] End 75,577,881 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 112,667,335 bp [2] End 112,680,244 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Brodmann area 46 cerebellar vermis internal globus pallidus superior vestibular nucleus hypothalamus subthalamic nucleus spinal cord C1 segment nucleus accumbens Top expressed in hypothalamus neural tube cerebellar cortex ganglionic eminence blastocyst morula dentate gyrus of hippocampal formation granule cell right kidney Cortex of frontal lobe bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GABA receptor binding microtubule binding ATPase binding protein binding beta-tubulin binding SNARE binding ubiquitin protein ligase binding Cellular component cytoplasm Golgi apparatus Golgi membrane intracellular anatomical structure autophagosome autophagosome membrane cytoplasmic vesicle cytosol Biological process positive regulation of ATP-dependent activity autophagy protein transport negative regulation of proteasomal protein catabolic process intra-Golgi vesicle-mediated transport macroautophagy autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11345 93739 Ensembl ENSG00000034713 ENSMUSG00000031950 UniProt P60520 P60521 RefSeq (mRNA) NM_007285 NM_026693 RefSeq (protein) NP_009216 NP_080969 Location (UCSC) Chr 16: 75.57 – 75.58 Mb Chr 8: 112.67 – 112.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor-associated protein-like 2 is a protein that in humans is encoded by the GABARAPL2 gene. ^{[5] [6]}

Interactions

GABARAPL2 has been shown to interact with ULK1, ^[7] ATG4B, ^{[8] [9]} and FAM134B. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000034713 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031950 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xin Y, Yu L, Chen Z, Zheng L, Fu Q, Jiang J, Zhang P, Gong R, Zhao S (Jun 2001). "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein". Genomics. 74 (3): 408–13. doi:10.1006/geno.2001.6555. PMID   11414770.
6. "Entrez Gene: GABARAPL2 GABA(A) receptor-associated protein-like 2".
7. Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID   11146101.
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
10. Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K.; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor (2015-06-18). "Regulation of endoplasmic reticulum turnover by selective autophagy". Nature. 522 (7556): 354–358. Bibcode:2015Natur.522..354K. doi:10.1038/nature14498. ISSN   0028-0836. PMID   26040720. S2CID   4449106.

Further reading

• Rohwer A, Kittstein W, Marks F, Gschwendt M (Jul 1999). "Cloning, expression and characterization of an A6-related protein". European Journal of Biochemistry. 263 (2): 518–25. doi: 10.1046/j.1432-1327.1999.00537.x . PMID   10406962.
• Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". The EMBO Journal. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC   310219 . PMID   10747018.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID   11146101.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E (Mar 2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs". Biochemical and Biophysical Research Communications. 292 (1): 256–62. doi:10.1006/bbrc.2002.6645. PMID   11890701.
• Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". The Journal of Biological Chemistry. 278 (16): 14053–8. doi: 10.1074/jbc.M212108200 . PMID   12473658.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E (Feb 2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". The Journal of Biological Chemistry. 281 (6): 3017–24. doi: 10.1074/jbc.M505888200 . PMID   16303767.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.