GCM1

Last updated
GCM1
Protein GCM1 PDB 1odh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GCM1 , GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDs OMIM: 603715; MGI: 108045; HomoloGene: 2702; GeneCards: GCM1; OMA:GCM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003643

NM_008103

RefSeq (protein)

NP_003634

NP_032129

Location (UCSC) Chr 6: 53.13 – 53.15 Mb Chr 9: 77.96 – 77.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene. [5] [6]

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [6]

In cancer patients, GCM1 expression has been linked to both higher and lower survival rates, depending on cancer type. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137270 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023333 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Akiyama Y, Hosoya T, Poole AM, Hotta Y (Jan 1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals". Proc Natl Acad Sci U S A. 93 (25): 14912–6. doi: 10.1073/pnas.93.25.14912 . PMC   26236 . PMID   8962155.
  6. 1 2 "Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)".
  7. "Research update from the MCM team (January 2025)". World Community Grid. 21 January 2025. Retrieved 21 January 2025.

Further reading