GOSR1

Last updated
GOSR1
Identifiers
Aliases GOSR1 , GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDs OMIM: 604026 MGI: 1858260 HomoloGene: 37977 GeneCards: GOSR1
Orthologs
SpeciesHumanMouse
Entrez

9527

53334

Ensembl

ENSG00000108587

ENSMUSG00000010392

UniProt

O95249

O88630

RefSeq (mRNA)

NM_001007024
NM_001007025
NM_004871

NM_016810
NM_001356321

RefSeq (protein)

NP_001007025
NP_001007026
NP_004862

NP_058090
NP_001343250

Location (UCSC) Chr 17: 30.48 – 30.53 Mb Chr 11: 76.62 – 76.65 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene. [5] [6] [7] [8]

Contents

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [8]

Interactions

GOSR1 has been shown to interact with USO1, [9] BET1L [9] [10] and STX5. [9] [11] [12] [13]

Related Research Articles

<i>N</i>-ethylmaleimide sensitive fusion protein Protein-coding gene in Homo sapiens

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.

STX1A Protein-coding gene in the species Homo sapiens

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

SNAP23 Protein-coding gene in the species Homo sapiens

Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

STX4 Protein-coding gene in the species Homo sapiens

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.

VAMP2 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

STX7 Protein-coding gene in the species Homo sapiens

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.

STX6 Protein-coding gene in the species Homo sapiens

Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.

NAPA (gene) Protein-coding gene in the species Homo sapiens

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

VAMP3 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.

STX5 Protein-coding gene in the species Homo sapiens

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.

STX2 Protein-coding gene in the species Homo sapiens

Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.

YKT6 Protein-coding gene in the species Homo sapiens

Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.

STX12

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.

STX8 Protein-coding gene in the species Homo sapiens

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.

BET1L Protein-coding gene in the species Homo sapiens

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

VAMP4 Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.

STX16 Protein-coding gene in the species Homo sapiens

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.

GOSR2 Protein-coding gene in the species Homo sapiens

Golgi SNAP receptor complex member 2 is a protein that in humans is encoded by the GOSR2 gene.

STX10

Syntaxin-10 (STX10) is a SNARE protein that is encoded by the STX10 gene. This protein is found in most vertebrates but is noticeably absent from mice. As with other SNARE proteins, STX10 facilitates vesicle fusion and thus is important for intracellular trafficking of proteins and other cellular components. More specifically, STX10 has been implicated in endosome to Golgi trafficking of the mannose 6-phosphate receptor and glucose transporter type 4.

STX17 Protein-coding gene in the species Homo sapiens

Syntaxin 17 is a protein that in humans is encoded by the STX17 gene. In horses a duplication in intron 6 causes progressive graying.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108587 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010392 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science. 272 (5265): 1161–3. Bibcode:1996Sci...272.1161S. doi:10.1126/science.272.5265.1161. PMID   8638159. S2CID   42813531.
  6. ↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
  7. ↑ Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC   404034 . PMID   15004235.
  8. 1 2 "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1".
  9. 1 2 3 Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC   2173270 . PMID   11927603.
  10. ↑ Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
  11. ↑ Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
  12. ↑ Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC   2133002 . PMID   9647643.
  13. ↑ Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi: 10.1074/jbc.272.41.25441 . PMID   9325254. S2CID   12818072.

Further reading



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