GOSR1

GOSR1
Identifiers
Aliases	GOSR1 , GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDs	OMIM: 604026; MGI: 1858260; HomoloGene: 37977; GeneCards: GOSR1; OMA:GOSR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 30,477,362 bp [1] End 30,527,592 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 76,617,428 bp [2] End 76,654,405 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell nipple tibia visceral pleura caput epididymis Achilles tendon pancreatic ductal cell parietal pleura corpus epididymis tail of epididymis Top expressed in lumbar subsegment of spinal cord stroma of bone marrow left lung lobe granulocyte jejunum epithelium of stomach parotid gland aortic valve seminal vesicula subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity SNARE binding Cellular component integral component of membrane Golgi membrane cis-Golgi network Golgi apparatus SNARE complex membrane Golgi medial cisterna cytosol transport vesicle Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport vesicle fusion intra-Golgi vesicle-mediated transport retrograde transport, endosome to Golgi regulation of vesicle targeting, to, from or within Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9527 53334 Ensembl ENSG00000108587 ENSMUSG00000010392 UniProt O95249 O88630 RefSeq (mRNA) NM_001007024 NM_001007025 NM_004871 NM_016810 NM_001356321 RefSeq (protein) NP_001007025 NP_001007026 NP_004862 NP_058090 NP_001343250 Location (UCSC) Chr 17: 30.48 – 30.53 Mb Chr 11: 76.62 – 76.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene. ^{[5] [6] [7] [8]}

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[8]

Interactions

GOSR1 has been shown to interact with USO1, ^[9] BET1L ^{[9] [10]} and STX5. ^{[9] [11] [12] [13]}

References

1. GRCh38: Ensembl release 89: ENSG00000108587 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010392 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science. 272 (5265): 1161–3. Bibcode:1996Sci...272.1161S. doi:10.1126/science.272.5265.1161. PMID   8638159. S2CID   42813531.
6. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.
7. Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC   404034 . PMID   15004235.
8. "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1".
9. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC   2173270 . PMID   11927603.
10. Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
11. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
12. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC   2133002 . PMID   9647643.
13. Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi: 10.1074/jbc.272.41.25441 . PMID   9325254. S2CID   12818072.

Further reading

• Nagahama M, Orci L, Ravazzola M, Amherdt M, Lacomis L, Tempst P, Rothman JE, Söllner TH (May 1996). "A v-SNARE implicated in intra-Golgi transport". The Journal of Cell Biology. 133 (3): 507–16. doi:10.1083/jcb.133.3.507. PMC   2120813 . PMID   8636227.
• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
• Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex" (PDF). The Journal of Biological Chemistry. 272 (41): 25441–4. doi: 10.1074/jbc.272.41.25441 . PMID   9325254. S2CID   12818072.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC   2133002 . PMID   9647643.
• Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W (Apr 1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics. 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID   10198168.
• Sagiv Y, Legesse-Miller A, Porat A, Elazar Z (Apr 2000). "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28". The EMBO Journal. 19 (7): 1494–504. doi:10.1093/emboj/19.7.1494. PMC   310219 . PMID   10747018.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC   2173270 . PMID   11927603.
• Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (Jun 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells". Immunity. 16 (6): 779–90. doi: 10.1016/S1074-7613(02)00324-2 . PMID   12121660.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC   515336 . PMID   15215310.
• Arasaki K, Taniguchi M, Tani K, Tagaya M (Jun 2006). "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex". Molecular Biology of the Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC   1474792 . PMID   16571679.