STX5

STX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EFO
Identifiers
Aliases	STX5 , SED5, STX5A, syntaxin 5
External IDs	OMIM: 603189 MGI: 1928483 HomoloGene: 2381 GeneCards: STX5
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.3 Start 62,806,860 bp [1] End 62,832,051 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 8,718,777 bp [2] End 8,733,433 bp [2]
RNA expression pattern Bgee Top expressed in blood Right lobe of liver salivary gland prostate thyroid gland Body of pancreas kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding GO:0001948 protein binding SNARE binding SNAP receptor activity cadherin binding Cellular component integral component of membrane vesicle endoplasmic reticulum membrane membrane endoplasmic reticulum ER to Golgi transport vesicle membrane SNARE complex endoplasmic reticulum-Golgi intermediate compartment membrane Golgi apparatus cytosol Golgi membrane endomembrane system Biological process positive regulation of protein catabolic process vesicle fusion with Golgi apparatus early endosome to Golgi transport vesicle docking COPII vesicle coating regulation of Golgi organization retrograde transport, endosome to Golgi Golgi disassembly vesicle fusion vesicle-mediated transport intracellular protein transport endoplasmic reticulum to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6811	56389
Ensembl	ENSG00000162236	ENSMUSG00000010110
UniProt	Q13190	Q8K1E0
RefSeq (mRNA)	NM_001244666 NM_003164 NM_001330294	NM_001167799 NM_019829
RefSeq (protein)	NP_001231595 NP_001317223 NP_003155	NP_001161271 NP_062803
Location (UCSC)	Chr 11: 62.81 – 62.83 Mb	Chr 19: 8.72 – 8.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene. ^{[5] [6] [7]}

Interactions

STX5 has been shown to interact with:

• BET1L, ^{[8] [9]}
• GOSR1, ^{[8] [10] [11] [12]}
• GOSR2, ^{[8] [10] [11]}
• NAPA, ^{[13] [14]} and
• USO1. ^{[8] [15]}

References

1. GRCh38: Ensembl release 89: ENSG00000162236 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000010110 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ravichandran V, Roche PA (Apr 1997). "Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein". Journal of Molecular Neuroscience. 8 (2): 159–61. doi:10.1007/BF02736780. PMID   9188044. S2CID   8942580.
6. Parlati F, Varlamov O, Paz K, McNew JA, Hurtado D, Söllner TH, Rothman JE (Apr 2002). "Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5424–9. doi: 10.1073/pnas.082100899 . PMC   122785 . PMID   11959998.
7. "Entrez Gene: STX5 syntaxin 5".
8. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC   2173270 . PMID   11927603.
9. Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
10. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/s0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
11. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC   2133002 . PMID   9647643.
12. Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". The Journal of Biological Chemistry. 272 (41): 25441–4. doi: 10.1074/jbc.272.41.25441 . PMID   9325254.
13. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
14. Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. doi: 10.1016/s0092-8674(00)81128-9 . PMID   9506515. S2CID   17285800.
15. Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID   10903204.

Further reading

• Nichols BJ, Pelham HR (Aug 1998). "SNAREs and membrane fusion in the Golgi apparatus". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1404 (1–2): 9–31. doi: 10.1016/S0167-4889(98)00044-5 . PMID   9714710.
• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
• Paek I, Orci L, Ravazzola M, Erdjument-Bromage H, Amherdt M, Tempst P, Söllner TH, Rothman JE (Jun 1997). "ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi". The Journal of Cell Biology. 137 (5): 1017–28. doi:10.1083/jcb.137.5.1017. PMC   2136225 . PMID   9166403.
• Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. doi: 10.1016/S0092-8674(00)81128-9 . PMID   9506515. S2CID   17285800.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC   2133002 . PMID   9647643.
• Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (Mar 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". Journal of Leukocyte Biology. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl: 10261/59829 . PMID   10080545. S2CID   18988377.
• Xu D, Joglekar AP, Williams AL, Hay JC (Dec 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry. 275 (50): 39631–9. doi: 10.1074/jbc.M007684200 . PMID   11035026.
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC   2173270 . PMID   11927603.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
• Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H (Dec 2002). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of Cell Biology. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMC   2173386 . PMID   12473691.
• Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (Jan 2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 100 (1): 32–7. doi: 10.1073/pnas.232701299 . PMC   140874 . PMID   12506202.
• Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (Jan 2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Molecular Biology of the Cell. 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC   307537 . PMID   14565970.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC   381410 . PMID   15029241.
• Suga K, Tomiyama T, Mori H, Akagawa K (Aug 2004). "Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production". The Biochemical Journal. 381 (Pt 3): 619–28. doi:10.1042/BJ20040618. PMC   1133870 . PMID   15109302.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC   515336 . PMID   15215310.