SYT2

SYT2
Identifiers
Aliases	SYT2 , SytII, CMS7, MYSPC, synaptotagmin 2, CMS7A, CMS7B
External IDs	OMIM: 600104 MGI: 99666 HomoloGene: 22516 GeneCards: SYT2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,710,454 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,690,331 bp
RNA expression pattern
	Top expressed in
	pons; ; external globus pallidus; ; cerebellar vermis; ; superior vestibular nucleus; ; inferior olivary nucleus; ; spinal ganglia; ; ventral tegmental area; ; inferior ganglion of vagus nerve; ; postcentral gyrus; ; Brodmann area 23;
	Top expressed in
	cerebellar cortex; ; inferior colliculus; ; medulla oblongata; ; pontine nuclei; ; medial vestibular nucleus; ; facial motor nucleus; ; anterior horn of spinal cord; ; cerebellar vermis; ; dorsal tegmental nucleus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; calcium ion binding ; inositol 1,3,4,5 tetrakisphosphate binding ; clathrin binding ; syntaxin binding ; protein binding ; calcium-dependent phospholipid binding ; SNARE binding ; phosphatidylserine binding ;
Cellular component	cell junction ; chromaffin granule membrane ; synaptic vesicle ; membrane ; cytoplasmic vesicle ; synapse ; integral component of membrane ; synaptic vesicle membrane ; plasma membrane ; clathrin-coated vesicle membrane ; axon ; dense core granule ; exocytic vesicle ;
Biological process	synaptic vesicle endocytosis ; cell differentiation ; neurotransmitter secretion ; positive regulation of dendrite extension ; vesicle fusion ; regulation of calcium ion-dependent exocytosis ; calcium ion-regulated exocytosis of neurotransmitter ; membrane organization ; regulation of dopamine secretion ; synaptic vesicle exocytosis ; vesicle-mediated transport ; calcium-ion regulated exocytosis ; cellular response to calcium ion ;
	Sources:Amigo / QuickGO
Orthologs
	127833
	20980
	ENSG00000143858
	ENSMUSG00000026452
	Q8N9I0
	P46097
	NM_001136504 ; NM_177402
	NM_009307 ; NM_001355726
	NP_001129976 ; NP_796376
	NP_033333 ; NP_001342655
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.^[5]^[6]

Related Research Articles

<span class="mw-page-title-main">Synaptotagmin</span>

Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, Extended-Synaptotagmin (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and B/K) proteins. The family includes synaptotagmin 1, a Ca²⁺ sensor in the membrane of the pre-synaptic axon terminal, coded by gene SYT1.

<span class="mw-page-title-main">C2 domain</span>

A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity.

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as heterogeneous nuclear ribonucleoprotein (hnRNP) Q or NS1-associated protein-1 (NSAP-1), is a protein that in humans is encoded by the SYNCRIP gene. As the name implies, SYNCRIP is localized predominantly in the cytoplasm. It is evolutionarily conserved across eukaryotes and participates in several cellular and disease pathways, especially in neuronal and muscular development. In humans, there are three isoforms, all of which are associated in vitro with pre-mRNAs, mRNA splicing intermediates, and mature mRNA-protein complexes, including mRNA turnover.

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

Synaptotagmin-like 2, also known as SYTL2, is a human gene.

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.

Exophilin 5, also known as EXPH5, is a human gene.

Synaptotagmin XIV is a protein that in humans is encoded by the SYT14 gene.

Kelch-like protein 3 is a protein in humans that is encoded by the KLHL3 gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143858 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026452 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl: 2027.42/47020 . PMID 7749232. S2CID 24653745.
↑ "Entrez Gene: SYT2 synaptotagmin II".

Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". The Journal of Biological Chemistry. 269 (46): 29206–11. doi: 10.1016/S0021-9258(19)62031-4 . PMID 7961887.
Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells". The Journal of Experimental Medicine. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646 . PMID 10330444.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi: 10.1074/jbc.275.13.9823 . PMID 10734137.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum". The Journal of Cell Biology. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286 . PMID 10952998.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325 . PMID 11381094.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Letters. 507 (3): 341–5. doi: 10.1016/S0014-5793(01)03000-9 . PMID 11696368. S2CID 29026112.
Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". The Journal of Biological Chemistry. 279 (13): 12574–9. doi: 10.1074/jbc.M310710200 . PMID 14709554.
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Molecular Cell. 15 (5): 741–51. doi: 10.1016/j.molcel.2004.07.018 . PMID 15350218.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143858 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026452 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749232-5] Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl: 2027.42/47020 . PMID 7749232. S2CID 24653745.

[entrez-6] "Entrez Gene: SYT2 synaptotagmin II".

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SYT2

Related Research Articles

References

Further reading