STX12

STX12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNX
Identifiers
Aliases	STX12 , STX13, STX14, syntaxin 12
External IDs	OMIM: 606892; MGI: 1931027; HomoloGene: 128192; GeneCards: STX12; OMA:STX12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.3 Start 27,773,219 bp [1] End 27,824,443 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D2.3|4 66.01 cM Start 132,580,812 bp [2] End 132,611,820 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus corpus epididymis Brodmann area 23 left lobe of thyroid gland right lobe of thyroid gland lower lobe of lung tail of epididymis superior frontal gyrus pars reticulata Brodmann area 46 Top expressed in transitional epithelium of urinary bladder medial ganglionic eminence pyloric antrum amygdala Region I of hippocampus proper habenula cingulate gyrus paraventricular nucleus of hypothalamus arcuate nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding SNARE binding Cellular component integral component of membrane vesicle endosome Golgi apparatus membrane Golgi membrane BLOC-1 complex phagophore assembly site SNARE complex phagocytic vesicle membrane raft endosome membrane endomembrane system early endosome membrane recycling endosome membrane synaptic vesicle integral component of synaptic vesicle membrane postsynaptic recycling endosome Biological process protein stabilization autophagosome assembly vesicle docking cholesterol efflux protein transport intracellular protein transport vesicle fusion vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23673 100226 Ensembl ENSG00000117758 ENSMUSG00000028879 UniProt Q86Y82 Q9ER00 RefSeq (mRNA) NM_177424 NM_133887 RefSeq (protein) NP_803173 NP_598648 Location (UCSC) Chr 1: 27.77 – 27.82 Mb Chr 4: 132.58 – 132.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene. ^{[5] [6]}

Interactions

STX12 has been shown to interact with PLDN. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000117758 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028879 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi: 10.1074/jbc.273.12.6944 . PMID   9507000.
6. "Entrez Gene: STX12 syntaxin 12".
7. Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID   10610180. S2CID   22843205.

Further reading

• Falcón-Pérez JM, Dell'Angelica EC (April 2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis". Pigment Cell Research. 15 (2): 82–6. doi: 10.1034/j.1600-0749.2002.1r082.x . PMID   11936273.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (April 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi: 10.1074/jbc.273.17.10317 . PMID   9553086.
• Prekeris R, Klumperman J, Chen YA, Scheller RH (November 1998). "Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes". The Journal of Cell Biology. 143 (4): 957–71. doi:10.1083/jcb.143.4.957. PMC   2132958 . PMID   9817754.
• Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi: 10.1074/jbc.273.51.34171 . PMID   9852078.
• McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M (August 1999). "Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13". Cell. 98 (3): 377–86. doi: 10.1016/S0092-8674(00)81966-2 . PMID   10458612. S2CID   2516425.
• Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID   10610180. S2CID   22843205.
• Minakami R, Kato A, Sugiyama H (June 2000). "Interaction of Vesl-1L/Homer 1c with syntaxin 13". Biochemical and Biophysical Research Communications. 272 (2): 466–71. doi:10.1006/bbrc.2000.2777. PMID   10833436.
• Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S (June 2000). "Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking". The European Journal of Neuroscience. 12 (6): 1913–23. doi: 10.1046/j.1460-9568.2000.00076.x . PMID   10886332. S2CID   19547759.
• Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, Hirling H (June 2002). "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD". The Journal of Cell Biology. 157 (7): 1197–209. doi:10.1083/jcb.200202022. PMC   2173541 . PMID   12070131.
• Sun W, Yan Q, Vida TA, Bean AJ (July 2003). "Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex". The Journal of Cell Biology. 162 (1): 125–37. doi:10.1083/jcb.200302083. PMC   2172712 . PMID   12847087.
• Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G (December 2004). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Molecular Biology of the Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC   532019 . PMID   15469992.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-12