STX7

STX7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GL2
Identifiers
Aliases	STX7 , syntaxin 7
External IDs	OMIM: 603217; MGI: 1858210; HomoloGene: 37823; GeneCards: STX7; OMA:STX7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 132,445,867 bp [1] End 132,513,198 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 24,025,200 bp [2] End 24,066,120 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell monocyte tendon of biceps brachii Achilles tendon middle temporal gyrus ganglionic eminence amniotic fluid internal globus pallidus glomerulus secondary oocyte Top expressed in yolk sac dentate gyrus of hippocampal formation granule cell submandibular gland stroma of bone marrow right kidney trigeminal ganglion granulocyte conjunctival fornix barrel cortex substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding chloride channel inhibitor activity syntaxin binding SNARE binding Cellular component integral component of membrane recycling endosome vesicle endosome late endosome early endosome membrane membrane tertiary granule plasma membrane endocytic vesicle lysosomal membrane SNARE complex azurophil granule early endosome immunological synapse perinuclear region of cytoplasm lysosome extracellular exosome synaptic vesicle endomembrane system Biological process positive regulation of receptor localization to synapse organelle localization positive regulation of T cell mediated cytotoxicity vesicle docking organelle assembly intracellular protein transport vesicle fusion vesicle-mediated transport regulation of protein localization to plasma membrane regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8417 53331 Ensembl ENSG00000079950 ENSMUSG00000019998 UniProt O15400 O70439 Q8BH40 RefSeq (mRNA) NM_003569 NM_001326578 NM_001326579 NM_001326580 NM_016797 NM_001358563 RefSeq (protein) NP_001313507 NP_001313508 NP_001313509 NP_003560 NP_058077 NP_001345492 Location (UCSC) Chr 6: 132.45 – 132.51 Mb Chr 10: 24.03 – 24.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene. ^{[5] [6]}

In melanocytic cells STX7 gene expression may be regulated by MITF. ^[7]

Interactions

STX7 has been shown to interact with STX8, ^[8] VPS18, ^[9] Vesicle-associated membrane protein 8 ^{[8] [10]} and VPS11. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000079950 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019998 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene. 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID   9358037.
6. "Entrez Gene: STX7 syntaxin 7".
7. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
8. Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
9. Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi: 10.1074/jbc.M101778200 . PMID   11382755.
10. Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi: 10.1074/jbc.M010838200 . PMID   11278762.

Further reading

• Wong SH, Xu Y, Zhang T, Hong W (January 1998). "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment". The Journal of Biological Chemistry. 273 (1): 375–80. doi: 10.1074/jbc.273.1.375 . PMID   9417091.
• Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (December 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi: 10.1074/jbc.273.51.34171 . PMID   9852078.
• Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH (November 1999). "Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking". Molecular Biology of the Cell. 10 (11): 3891–908. doi:10.1091/mbc.10.11.3891. PMC   25687 . PMID   10564279.
• Nakamura N, Yamamoto A, Wada Y, Futai M (March 2000). "Syntaxin 7 mediates endocytic trafficking to late endosomes". The Journal of Biological Chemistry. 275 (9): 6523–9. doi: 10.1074/jbc.275.9.6523 . PMID   10692457.
• Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457–64. doi: 10.1016/S0896-6273(00)81177-0 . PMID   10839363.
• Mullock BM, Smith CW, Ihrke G, Bright NA, Lindsay M, Parkinson EJ, Brooks DA, Parton RG, James DE, Luzio JP, Piper RC (September 2000). "Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion". Molecular Biology of the Cell. 11 (9): 3137–53. doi:10.1091/mbc.11.9.3137. PMC   14981 . PMID   10982406.
• Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
• Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi: 10.1074/jbc.M010838200 . PMID   11278762.
• Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi: 10.1074/jbc.M101778200 . PMID   11382755.
• Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". The Journal of Biological Chemistry. 276 (35): 33054–60. doi: 10.1074/jbc.M009913200 . PMID   11423532.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (February 2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nature Structural Biology. 9 (2): 107–11. doi:10.1038/nsb746. hdl: 11858/00-001M-0000-0012-F459-F . PMID   11786915. S2CID   17724790.
• Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R (September 2002). "The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly". The Journal of Biological Chemistry. 277 (39): 36449–56. doi: 10.1074/jbc.M204369200 . hdl: 11858/00-001M-0000-0012-F2E6-3 . PMID   12114520.
• Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (November 2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". The Biochemical Journal. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC   1222979 . PMID   12175335.
• Collins RF, Schreiber AD, Grinstein S, Trimble WS (September 2002). "Syntaxins 13 and 7 function at distinct steps during phagocytosis". Journal of Immunology. 169 (6): 3250–6. doi: 10.4049/jimmunol.169.6.3250 . PMID   12218144.
• Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (December 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi: 10.1074/mcp.M200066-MCP200 . PMID   12543931.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Suzuki J, Ohnishi H, Wada A, Hirayama T, Ohno H, Ueda N, Yasuda H, Iiri T, Wada Y, Futai M, Mashima H (July 2003). "Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA". The Journal of Biological Chemistry. 278 (28): 25585–90. doi: 10.1074/jbc.M212445200 . PMID   12730232.