STX7

Last updated
STX7
Protein STX7 PDB 1gl2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STX7 , syntaxin 7
External IDs OMIM: 603217 MGI: 1858210 HomoloGene: 37823 GeneCards: STX7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003569
NM_001326578
NM_001326579
NM_001326580

NM_016797
NM_001358563

RefSeq (protein)

NP_001313507
NP_001313508
NP_001313509
NP_003560

NP_058077
NP_001345492

Location (UCSC) Chr 6: 132.45 – 132.51 Mb Chr 10: 24.03 – 24.07 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene. [5] [6]

Contents

In melanocytic cells STX7 gene expression may be regulated by MITF. [7]

Interactions

STX7 has been shown to interact with STX8, [8] VPS18, [9] Vesicle-associated membrane protein 8 [8] [10] and VPS11. [9]

Related Research Articles

<span class="mw-page-title-main">SNARE protein</span> Protein family

SNARE proteins – "SNAPREceptors" – are a large protein family consisting of at least 24 members in yeasts, more than 60 members in mammalian cells, and some numbers in plants. The primary role of SNARE proteins is to mediate the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles with membrane-bound compartments. The best studied SNAREs are those that mediate the release of synaptic vesicles containing neurotransmitters in neurons. These neuronal SNAREs are the targets of the neurotoxins responsible for botulism and tetanus produced by certain bacteria.

<span class="mw-page-title-main">Synaptobrevin</span>

Synaptobrevins are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton (kDa) that are part of the vesicle-associated membrane protein (VAMP) family.

<span class="mw-page-title-main">SNAP25</span> Protein-coding gene in the species Homo sapiens

Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.

<span class="mw-page-title-main">STX1A</span> Protein-coding gene in the species Homo sapiens

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

<span class="mw-page-title-main">SNAP23</span> Protein-coding gene in the species Homo sapiens

Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

<span class="mw-page-title-main">RAB11A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

<span class="mw-page-title-main">STX4</span> Protein-coding gene in the species Homo sapiens

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.

<span class="mw-page-title-main">SYT1</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.

<span class="mw-page-title-main">VAMP2</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

<span class="mw-page-title-main">Vesicle-associated membrane protein 7</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 7 (VAMP-7), is a protein that in humans is encoded by the VAMP7 gene also known as the or SYBL1 gene.

<span class="mw-page-title-main">STX6</span> Protein-coding gene in the species Homo sapiens

Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.

<span class="mw-page-title-main">NAPA (gene)</span> Protein-coding gene in the species Homo sapiens

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

<span class="mw-page-title-main">VAMP3</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.

<span class="mw-page-title-main">STX2</span> Protein-coding gene in the species Homo sapiens

Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.

<span class="mw-page-title-main">STX12</span> Protein-coding gene in the species Homo sapiens

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.

<span class="mw-page-title-main">Vesicle-associated membrane protein 8</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

<span class="mw-page-title-main">STX8</span> Protein-coding gene in the species Homo sapiens

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.

<span class="mw-page-title-main">VTI1B</span> Protein-coding gene in the species Homo sapiens

Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene.

<span class="mw-page-title-main">VAMP4</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.

<span class="mw-page-title-main">VTI1A</span> Protein-coding gene in the species Homo sapiens

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000079950 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019998 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang H, Frelin L, Pevsner J (October 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene. 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID   9358037.
  6. "Entrez Gene: STX7 syntaxin 7".
  7. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
  8. 1 2 Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (December 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
  9. 1 2 Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". The Journal of Biological Chemistry. 276 (31): 29393–402. doi: 10.1074/jbc.M101778200 . PMID   11382755.
  10. Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi: 10.1074/jbc.M010838200 . PMID   11278762.

Further reading