VPS11

VPS11
Identifiers
Aliases	VPS11 , END1, PEP5, RNF108, hHLD12, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes
External IDs	OMIM: 608549 MGI: 1918982 HomoloGene: 6673 GeneCards: VPS11
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.3 Start 119,067,692 bp [1] End 119,081,978 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.2 Start 44,259,046 bp [2] End 44,272,967 bp [2]
RNA expression pattern Bgee Top expressed in pituitary gland prefrontal cortex anterior pituitary cerebellar hemisphere More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein-macromolecule adaptor activity protein domain specific binding metal ion binding GO:0001948 protein binding syntaxin binding Cellular component HOPS complex endosome late endosome late endosome membrane membrane endocytic vesicle autophagosome lysosomal membrane early endosome lysosome GO:0016023 cytoplasmic vesicle clathrin-coated vesicle Biological process endosomal vesicle fusion regulation of protein stability regulation of organelle assembly positive regulation of protein targeting to mitochondrion endosome to lysosome transport autophagy positive regulation of early endosome to late endosome transport protein transport intracellular protein transport vesicle-mediated transport regulation of SNARE complex assembly lysosome organization endosome organization vesicle docking involved in exocytosis transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55823	71732
Ensembl	ENSG00000160695 ENSG00000280616	ENSMUSG00000032127
UniProt	Q9H270	Q91W86
RefSeq (mRNA)	NM_001290185 NM_021729	NM_027889 NM_001357393
RefSeq (protein)	NP_001277114 NP_068375 NP_001365147 NP_001365148 NP_001365149 NP_001365150	NP_082165 NP_001344322
Location (UCSC)	Chr 11: 119.07 – 119.08 Mb	Chr 9: 44.26 – 44.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene. ^[5]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. ^[5]

Interactions

VPS11 has been shown to interact with VPS18, ^[6] VPS33A ^[6] and STX7. ^[6]

References

1. ENSG00000280616 GRCh38: Ensembl release 89: ENSG00000160695, ENSG00000280616 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032127 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)".
6. Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi: 10.1074/jbc.M101778200 . PMID   11382755.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene. 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID   11250079.
• Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi: 10.1074/jbc.M101778200 . PMID   11382755.
• Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID   14623309.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.