SYT9

SYT9
Identifiers
Aliases	SYT9 , synaptotagmin 9
External IDs	OMIM: 613528; MGI: 1926373; HomoloGene: 11062; GeneCards: SYT9; OMA:SYT9 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 7,238,778 bp [1] End 7,469,043 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,969,935 bp [2] End 107,147,863 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus cerebellar vermis corpus callosum lateral nuclear group of thalamus subthalamic nucleus cerebellar hemisphere inferior ganglion of vagus nerve external globus pallidus ventral tegmental area pars reticulata Top expressed in habenula medial dorsal nucleus lumbar spinal ganglion medial geniculate nucleus molar Epithelium of choroid plexus lateral geniculate nucleus lobe of cerebellum cerebellar vermis superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent phospholipid binding metal ion binding clathrin binding calcium ion binding syntaxin binding identical protein binding phosphatidylserine binding phosphatidylinositol-4,5-bisphosphate binding SNARE binding Cellular component cytoplasmic vesicle integral component of membrane cell junction synapse dense core granule synaptic vesicle membrane secretory granule membrane membrane secretory granule plasma membrane clathrin-coated vesicle membrane integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse exocytic vesicle Biological process regulation of insulin secretion positive regulation of calcium ion-dependent exocytosis regulation of calcium ion-dependent exocytosis vesicle fusion calcium ion-regulated exocytosis of neurotransmitter membrane organization calcium-dependent activation of synaptic vesicle fusion regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143425 60510 Ensembl ENSG00000170743 ENSMUSG00000062542 UniProt Q86SS6 Q9R0N9 RefSeq (mRNA) NM_175733 NM_021889 RefSeq (protein) NP_783860 NP_068689 Location (UCSC) Chr 11: 7.24 – 7.47 Mb Chr 7: 106.97 – 107.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene. ^{[5] [6]}

Interactions

SYT9 has been shown to interact with SYNCRIP, ^[7] TUBB ^[8] and TRPV1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000170743 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062542 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID   11543631.
6. "Entrez Gene: SYT9 synaptotagmin IX".
7. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi: 10.1074/jbc.275.13.9823 . PMID   10734137.
8. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi: 10.1242/jcs.00719 . PMID   12966166.
9. Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi: 10.1074/jbc.M311515200 . PMID   15066994.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi: 10.1074/jbc.M311515200 . PMID   15066994.
• Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi: 10.1242/jcs.00719 . PMID   12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. Bibcode:2002FEBSL.517..167D. doi: 10.1016/S0014-5793(02)02614-5 . PMID   12062430. S2CID   84792445.

• Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi: 10.1016/S0896-6273(02)00671-2 . PMID   12062043. S2CID   16768299.
• Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi: 10.1074/jbc.C100588200 . PMID   11751925.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi: 10.1074/jbc.275.13.9823 . PMID   10734137.
• Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID   8901523.