STX8

STX8
Identifiers
Aliases	STX8 , CARB, syntaxin 8
External IDs	OMIM: 604203; MGI: 1890156; HomoloGene: 37973; GeneCards: STX8; OMA:STX8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 9,250,471 bp [1] End 9,576,591 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 67,857,019 bp [2] End 68,097,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis Achilles tendon gastric mucosa oocyte islet of Langerhans tibial arteries muscle layer of sigmoid colon muscle of thigh Top expressed in vestibular membrane of cochlear duct spermatid facial motor nucleus spermatocyte motor neuron seminiferous tubule epithelium of lens right lung lobe saccule transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding chloride channel inhibitor activity syntaxin binding ubiquitin protein ligase binding SNARE binding Cellular component integral component of membrane recycling endosome vesicle endosome late endosome membrane late endosome membrane integral component of plasma membrane lysosomal membrane trans-Golgi network early endosome endoplasmic reticulum perinuclear region of cytoplasm cytosol SNARE complex phagocytic vesicle endomembrane system Biological process endosome to lysosome transport vesicle docking early endosome to late endosome transport intracellular protein transport vesicle-mediated transport regulation of protein localization to plasma membrane vesicle fusion cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9482 55943 Ensembl ENSG00000170310 ENSMUSG00000020903 UniProt Q9UNK0 O88983 RefSeq (mRNA) NM_004853 NM_018768 NM_001356314 NM_001361350 NM_001361351 NM_001361352 RefSeq (protein) NP_004844 NP_061238 NP_001343243 NP_001348279 NP_001348280 NP_001348281 Location (UCSC) Chr 17: 9.25 – 9.58 Mb Chr 11: 67.86 – 68.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. ^{[5] [6] [7]}

Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. ^[8] The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes. ^[9]

Interactions

STX8 has been shown to interact with Vesicle-associated membrane protein 8, ^[10] VTI1B ^{[11] [12]} and STX7. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000170310 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020903 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi: 10.1074/jbc.273.51.34171 . PMID   9852078.
6. Thoreau V, Bergès T, Callebaut I, Guillier-Gencik Z, Gressin L, Bernheim A, Karst F, Mornon JP, Kitzis A, Chomel JC (Apr 1999). "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)". Biochemical and Biophysical Research Communications. 257 (2): 577–83. Bibcode:1999BBRC..257..577T. doi:10.1006/bbrc.1999.0503. PMID   10198254.
7. "Entrez Gene: STX8 syntaxin 8".
8. Zhang L, Kang L, Bond W, Zhang N (Feb 2009). "Interaction between syntaxin 8 and HECTd3, a HECT domain ligase". Cellular and Molecular Neurobiology. 29 (1): 115–21. doi:10.1007/s10571-008-9303-0. PMC   11506180 . PMID   18821010. S2CID   23216243.
9. Kasai K, Suga K, Izumi T, Akagawa K (October 2008). "Syntaxin 8 has two functionally distinct di-leucine-based motifs". Cellular & Molecular Biology Letters. 13 (1): 144–54. doi:10.2478/s11658-007-0043-9. PMC   6275627 . PMID   17965969.
10. Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
11. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
12. Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (Mar 2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). Journal of Cell Science. 113 ( Pt 6) (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID   10683148.

Further reading

• Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH (Nov 1999). "Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking". Molecular Biology of the Cell. 10 (11): 3891–908. doi:10.1091/mbc.10.11.3891. PMC   25687 . PMID   10564279.
• Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (Mar 2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). Journal of Cell Science. 113 ( Pt 6) (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID   10683148.
• McShea A, Samuel T, Eppel JT, Galloway DA, Funk JO (Jul 2000). "Identification of CIP-1-associated regulator of cyclin B (CARB), a novel p21-binding protein acting in the G2 phase of the cell cycle". The Journal of Biological Chemistry. 275 (30): 23181–6. doi: 10.1074/jbc.M001772200 . PMID   10781590.
• Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH (May 2000). "SNAREs contribute to the specificity of membrane fusion". Neuron. 26 (2): 457–64. doi: 10.1016/S0896-6273(00)81177-0 . PMID   10839363.
• Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". The EMBO Journal. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
• Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (Jun 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". The Journal of Biological Chemistry. 276 (23): 19820–7. doi: 10.1074/jbc.M010838200 . PMID   11278762.
• Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (Feb 2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nature Structural Biology. 9 (2): 107–11. doi:10.1038/nsb746. hdl: 11858/00-001M-0000-0012-F459-F . PMID   11786915. S2CID   17724790.
• Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (Nov 2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". The Biochemical Journal. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC   1222979 . PMID   12175335.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC   129961 . PMID   12388752.
• Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C (Nov 2003). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochemical and Biophysical Research Communications. 311 (3): 577–82. Bibcode:2003BBRC..311..577K. doi:10.1016/j.bbrc.2003.10.030. PMID   14623309.
• Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA (Mar 2004). "Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease". Journal of Neuroscience Research. 75 (5): 698–703. doi:10.1002/jnr.20028. PMID   14991845. S2CID   39141122.
• Bilan F, Thoreau V, Nacfer M, Dérand R, Norez C, Cantereau A, Garcia M, Becq F, Kitzis A (Apr 2004). "Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity". Journal of Cell Science. 117 (Pt 10): 1923–35. doi: 10.1242/jcs.01070 . PMID   15039462.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.