SYT7

SYT7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8K
Identifiers
Aliases	SYT7 , IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7
External IDs	OMIM: 604146; MGI: 1859545; HomoloGene: 20889; GeneCards: SYT7; OMA:SYT7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.2 Start 61,513,714 bp [1] End 61,581,148 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 10,366,454 bp [2] End 10,430,544 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right hemisphere of cerebellum right frontal lobe Brodmann area 9 prefrontal cortex cerebellar vermis cingulate gyrus anterior cingulate cortex right lobe of liver pituitary gland Top expressed in medial dorsal nucleus medial geniculate nucleus dentate gyrus piriform cortex substantia nigra primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex cerebellar vermis lobe of cerebellum More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding metal ion binding protein binding SNARE binding syntaxin binding clathrin binding phosphatidylinositol-4,5-bisphosphate binding calcium-dependent phospholipid binding calmodulin binding phosphatidylserine binding Cellular component integral component of membrane membrane synapse synaptic vesicle membrane cell junction terminal bouton dense core granule extracellular exosome cytoplasmic vesicle transport vesicle membrane cytosol synaptic vesicle presynaptic membrane lysosome peroxisome peroxisomal membrane phagocytic vesicle membrane plasma membrane lysosomal membrane early phagosome dendrite neuronal cell body axon terminus axon neuron projection exocytic vesicle hippocampal mossy fiber to CA3 synapse glutamatergic synapse GABA-ergic synapse integral component of presynaptic membrane Biological process regulation of insulin secretion positive regulation of calcium ion-dependent exocytosis exocytosis regulation of bone remodeling plasma membrane repair calcium-ion regulated exocytosis regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of glucagon secretion phagosome-lysosome fusion synaptic vesicle recycling vesicle-mediated cholesterol transport regulation of phagocytosis vesicle fusion calcium ion regulated lysosome exocytosis phagocytosis regulation of dopamine secretion short-term synaptic potentiation vesicle-mediated transport cellular response to calcium ion calcium-dependent activation of synaptic vesicle fusion regulation of synaptic vesicle endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9066 54525 Ensembl ENSG00000011347 ENSMUSG00000024743 UniProt O43581 Q9R0N7 RefSeq (mRNA) NM_001252065 NM_001300773 NM_004200 NM_001365809 NM_001370210 NM_001370211 NM_018801 NM_173067 NM_173068 NM_001373944 RefSeq (protein) NP_001238994 NP_001287702 NP_004191 NP_001352738 NP_001357139 NP_001357140 NP_061271 NP_775090 NP_775091 Location (UCSC) Chr 11: 61.51 – 61.58 Mb Chr 19: 10.37 – 10.43 Mb PubMed search [3] [4]
Wikidata
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Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene. ^{[5] [6]}

Function

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM] ^[6]

Interactions

SYT7 has been shown to interact with SYNCRIP. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID   9615227.
6. "Entrez Gene: SYT7 synaptotagmin VII".
7. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi: 10.1074/jbc.275.13.9823 . PMID   10734137.

Further reading

• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID   7791877. S2CID   4265549.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID   8901523.
• Craxton M, Goedert M (November 1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Letters. 460 (3): 417–22. Bibcode:1999FEBSL.460..417C. doi: 10.1016/S0014-5793(99)01382-4 . PMID   10556508. S2CID   19207631.
• Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Research. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC   310991 . PMID   10613842.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi: 10.1074/jbc.275.13.9823 . PMID   10734137.
• Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW (May 2001). "The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi". The Journal of Experimental Medicine. 193 (9): 1097–104. doi:10.1084/jem.193.9.1097. PMC   2193425 . PMID   11342594.
• Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K (July 2002). "Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human". The Biochemical Journal. 365 (Pt 1): 173–80. doi:10.1042/BJ20011877. PMC   1222667 . PMID   12071850.

External links

• Overview of all the structural information available in the PDB for UniProt : O43581 (Human Synaptotagmin-7) at the PDBe-KB .
• Overview of all the structural information available in the PDB for UniProt : Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB .