COPB2

Last updated

COPB2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COPB2 , beta'-COP, coatomer protein complex subunit beta 2, MCPH19, COPI coat complex subunit beta 2
External IDs OMIM: 606990; MGI: 1354962; HomoloGene: 3499; GeneCards: COPB2; OMA:COPB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004766

NM_015827

RefSeq (protein)

NP_004757

NP_056642

Location (UCSC) Chr 3: 139.35 – 139.39 Mb Chr 9: 98.45 – 98.47 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coatomer subunit beta is a protein that is encoded by the COPB2 gene in humans. [5] [6]

Contents

Function

The Golgi coatomer complex (see MIM 601924) constitutes the coat of non-clathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM] [6]

Interactions

COPB2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184432 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032458 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (February 1999). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 82 (3–4): 226–7. doi:10.1159/000015107. PMID   9858824. S2CID   46851294.
  6. 1 2 "Entrez Gene: COPB2 coatomer protein complex, subunit beta 2 (beta prime)".
  7. Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC   306616 . PMID   10921873.
  8. Lowe M, Kreis TE (November 1996). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725–30. doi: 10.1074/jbc.271.48.30725 . PMID   8940050.
  9. England K, Ashford D, Kidd D, Rumsby M (June 2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. doi:10.1016/s0898-6568(01)00277-7. PMID   11897493.
  10. Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM (September 2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport". Mol. Biol. Cell. 11 (9): 3155–68. doi:10.1091/mbc.11.9.3155. PMC   14982 . PMID   10982407.

Further reading