RGS4

Last updated
RGS4
Protein RGS4 PDB 1agr.png
Identifiers
Aliases RGS4 , Rgs4, AA004315, AA597169, ESTM48, ESTM50, RGP4, SCZD9, regulator of G-protein signaling 4, regulator of G protein signaling 4
External IDs OMIM: 602516 MGI: 108409 HomoloGene: 4100 GeneCards: RGS4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001102445
NM_001113380
NM_001113381
NM_005613

NM_009062

RefSeq (protein)

NP_001095915
NP_001106851
NP_001106852
NP_005604
NP_005604.1

Contents

NP_033088

Location (UCSC) Chr 1: 163.07 – 163.08 Mb Chr 1: 169.57 – 169.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling. [5]

Function

Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. [6] RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain which conveys GAP activity. [7] Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. [5]

Clinical significance

A number of studies associate the RGS4 gene with schizophrenia, [8] [9] [10] [11] while some fail to detect an association. [12]

RGS4 is also of interest as one of the three main RGS proteins (along with RGS9 and RGS17) involved in terminating signalling by the mu opioid receptor, [13] and may be important in the development of tolerance to opioid drugs. [14] [15] [16] [17] [18]

Inhibitors

Interactions

RGS4 has been shown to interact with:

Related Research Articles

<span class="mw-page-title-main">G protein-coupled receptor kinase 2</span> Enzyme

G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. GRK2 was initially called Beta-adrenergic receptor kinase, and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).

<span class="mw-page-title-main">RGS2</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

<span class="mw-page-title-main">GNAQ</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11, it functions as a Gq alpha subunit.

<span class="mw-page-title-main">Regulator of G protein signaling</span>

Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase activity of heterotrimeric G-protein α-subunits.

<span class="mw-page-title-main">GNAO1</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.

<span class="mw-page-title-main">RGS16</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.

<span class="mw-page-title-main">RGS19</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

<span class="mw-page-title-main">GNB5</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

<span class="mw-page-title-main">RGS3</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.

<span class="mw-page-title-main">RGS7</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

<span class="mw-page-title-main">COPB2</span> Protein-coding gene in humans

Coatomer subunit beta is a protein that is encoded by the COPB2 gene in humans.

<span class="mw-page-title-main">RGS5</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.

<span class="mw-page-title-main">RGS1</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

<span class="mw-page-title-main">RGS10</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.

<span class="mw-page-title-main">RGS12</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.

<span class="mw-page-title-main">RGS8</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.

<span class="mw-page-title-main">GNAI3</span> Protein-coding gene in humans

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.

<span class="mw-page-title-main">RGS13</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.

<span class="mw-page-title-main">RGS17</span> Protein-coding gene in the species Homo sapiens

Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.

<span class="mw-page-title-main">CCG-4986</span> Chemical compound

CCG-4986 is a drug which is the first non-peptide compound discovered that acts as a selective inhibitor of the regulator of G protein signalling protein subtype RGS4. Regulators of G protein signalling are proteins which act to limit and shorten the response produced inside a cell following activation of a G protein-coupled receptor. Since different RGS subtypes are expressed in different tissues and are associated with particular receptors, this makes it possible for selective inhibitors of RGS proteins to be developed, which should be able to enhance the activity of a particular receptor in a defined target tissue, but not elsewhere in the body.

References

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  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038530 - Ensembl, May 2017
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  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Further reading