STX11 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | STX11 , FHL4, HLH4, HPLH4, syntaxin 11 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605014 MGI: 1921982 HomoloGene: 2792 GeneCards: STX11 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Syntaxin 11, also known as STX11, is a human gene that is a member of the t-SNARE family. [5]
STX11 has been shown to interact with SNAP25 [6] [7] and SNAP23. [6] [8]
Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.
Hemophagocytic lymphohistiocytosis (HLH), also known as haemophagocytic lymphohistiocytosis, and hemophagocytic or haemophagocytic syndrome, is an uncommon hematologic disorder seen more often in children than in adults. It is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages, characterised by proliferation of morphologically benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. It is classified as one of the cytokine storm syndromes. There are inherited and non-inherited (acquired) causes of hemophagocytic lymphohistiocytosis (HLH).
Protein unc-13 homolog D, also known as munc13-4, is a protein that in humans is encoded by the UNC13D gene.
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.
Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.
N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.
Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.
Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.
Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.
Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.
Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.
Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene.
Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.
Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.
Vesicle-associated membrane protein 1 (VAMP1) is a protein that in humans is encoded by the VAMP1 gene.
Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.
E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.
Syntaxin 3, also known as STX3, is a protein which in humans is encoded by the STX3 gene.