COPE (gene)

COPE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A1V, 5A1Y
Identifiers
Aliases	COPE , epsilon-COP, coatomer protein complex subunit epsilon, COPI coat complex subunit epsilon
External IDs	OMIM: 606942 MGI: 1891702 HomoloGene: 5254 GeneCards: COPE
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,919,387 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,765,643 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; left adrenal gland; ; right adrenal gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach; ; body of pancreas; ; minor salivary gland; ; cingulate gyrus; ; stromal cell of endometrium;
	Top expressed in
	seminal vesicula; ; saccule; ; islet of Langerhans; ; calvaria; ; salivary gland; ; duodenum; ; yolk sac; ; submandibular gland; ; lip; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity ; protein binding ;
Cellular component	cytoplasm ; cytosol ; Golgi apparatus ; membrane ; Golgi membrane ; COPI-coated vesicle membrane ; transport vesicle ; nucleoplasm ; COPI vesicle coat ; cytoplasmic vesicle ; endoplasmic reticulum membrane ;
Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; endoplasmic reticulum to Golgi vesicle-mediated transport ; protein transport ; intra-Golgi vesicle-mediated transport ; vesicle-mediated transport ;
	Sources:Amigo / QuickGO
Orthologs
	11316
	59042
	ENSG00000105669
	ENSMUSG00000055681
	O14579
	O89079
	NM_007263 ; NM_199442 ; NM_199444 ; NM_001330469 ; NM_025088 Contents Function ; Interactions ; References ; External links ; Further reading ;
	NM_021538
	NP_001317398 ; NP_009194 ; NP_955474 ; NP_955476
	NP_067513
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 24, 2024

Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.^[5]^[6]

Function

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

COPE (gene) has been shown to interact with COPA.^[7]^[8]^[9]

Related Research Articles

COPI is a coatomer, a protein complex that coats vesicles transporting proteins from the cis end of the Golgi complex back to the rough endoplasmic reticulum (ER), where they were originally synthesized, and between Golgi compartments. This type of transport is retrograde transport, in contrast to the anterograde transport associated with the COPII protein. The name "COPI" refers to the specific coat protein complex that initiates the budding process on the cis-Golgi membrane. The coat consists of large protein subcomplexes that are made of seven different protein subunits, namely α, β, β', γ, δ, ε and ζ.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene.

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B.

H⁺/Cl⁻ exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.

Coatomer subunit beta is a protein that is encoded by the COPB2 gene in humans.

Coatomer subunit gamma-2 is a protein that in humans is encoded by the COPG2 gene.

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene. It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.

Spermatid perinuclear RNA-binding protein is a protein that in humans is encoded by the STRBP gene.

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

Polyadenylate-binding protein-interacting protein 2 is a protein that in humans is encoded by the PAIP2 gene.

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. It is a subunit of the CCR4-Not deadenylase complex.

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

Ankyrin repeat domain-containing protein 13C is a protein that in humans is encoded by the ANKRD13C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105669 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055681 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821–4. Bibcode:1999CBio....9..821S. doi: 10.1016/S0960-9822(99)80365-0 . PMID 10469566. S2CID 16182290.
1 2 "Entrez Gene: COPE coatomer protein complex, subunit epsilon".
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
↑ Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616 . PMID 10921873.
↑ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028 . PMID 8858162.

External links

Human COPE genome location and COPE gene details page in the UCSC Genome Browser .

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. Bibcode:1993Natur.364..732O. doi:10.1038/364732a0. PMID 8355790. S2CID 4348442.
Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028 . PMID 8858162.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. Bibcode:1998PNAS...95.2140P. doi: 10.1073/pnas.95.5.2140 . PMC 19276 . PMID 9482852.
de La Vega LA, Stockert RJ (1999). "The cytoplasmic coatomer protein COPI. A potential translational regulator". J. Biol. Chem. 274 (44): 31135–8. doi: 10.1074/jbc.274.44.31135 . PMID 10531302.
Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616 . PMID 10921873.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi: 10.1074/jbc.M102786200 . PMID 11323436.
Xu Y, Martin S, James DE, Hong W (2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961 . PMID 12388752.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105669 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055681 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10469566-5] Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821–4. Bibcode:1999CBio....9..821S. doi: 10.1016/S0960-9822(99)80365-0 . PMID 10469566. S2CID 16182290.

[entrez-6] 1 2 "Entrez Gene: COPE coatomer protein complex, subunit epsilon".

[pmid16169070-7] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

[pmid10921873-8] Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616 . PMID 10921873.

[pmid8858162-9] Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028 . PMID 8858162.

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