SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene. [5] The protein belongs to a protein family that are homologous to yeast Sec24. [6] It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. [5]
The Coat Protein Complex II, or COPII, is a group of proteins that facilitate the formation of vesicles to transport proteins from the endoplasmic reticulum to the Golgi apparatus or endoplasmic-reticulum–Golgi intermediate compartment. This process is termed anterograde transport, in contrast to the retrograde transport associated with the COPI complex. COPII is assembled in two parts: first an inner layer of Sar1, Sec23, and Sec24 forms; then the inner coat is surrounded by an outer lattice of Sec13 and Sec31.
Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.
Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, also known as KDELR1, is a protein which in humans is encoded by the KDELR1 gene.
Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.
Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.
Nucleotide exchange factor SIL1 is a protein that in humans is encoded by the SIL1 gene.
Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.
Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.
BET1 homolog is a protein that in humans is encoded by the BET1 gene.
ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.
Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.
Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies. Surf4 is involved in trafficking soluble proteins, namely lipoproteins and PCSK9. It recognizes cargo proteins via a three-amino-acid sequence near the N-termini. The related protein in yeast is called Erv29p.
Golgi SNAP receptor complex member 2 is a protein that in humans is encoded by the GOSR2 gene.
Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.
Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.
Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.
Protein transport protein Sec24B is a protein that in humans is encoded by the SEC24B gene.
SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.
SEC31 is a protein which in yeast promotes the formation of COPII transport vesicles from the Endoplasmic Reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
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