VTI1B

VTI1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V8S
Identifiers
Aliases	VTI1B , VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1, vesicle transport through interaction with t-SNAREs 1B
External IDs	OMIM: 603207 MGI: 1855688 HomoloGene: 38178 GeneCards: VTI1B
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q24.1 Start 67,647,085 bp [1] End 67,674,820 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 79,202,791 bp [2] End 79,219,441 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala nucleus accumbens prefrontal cortex putamen caudate nucleus hypothalamus optic nerve dorsolateral prefrontal cortex abdominal fat Brodmann area 9 Top expressed in globus pallidus olfactory tubercle amygdala nucleus accumbens cingulate gyrus arcuate nucleus prefrontal cortex paraventricular nucleus of hypothalamus ventromedial nucleus medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding chloride channel inhibitor activity SNARE binding Cellular component integral component of membrane recycling endosome vesicle endosome Golgi apparatus intracellular membrane-bounded organelle late endosome membrane synaptic vesicle membrane lysosomal membrane neuronal cell body perinuclear region of cytoplasm lysosome ER to Golgi transport vesicle membrane SNARE complex endoplasmic reticulum membrane extracellular region cytosol platelet alpha granule lumen early endosome membrane recycling endosome membrane Biological process membrane fusion vesicle docking involved in exocytosis autophagosome maturation protein transport cell population proliferation intracellular protein transport vesicle-mediated transport regulation of protein localization to plasma membrane Golgi to vacuole transport vesicle fusion with Golgi apparatus endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein targeting to vacuole retrograde transport, endosome to Golgi platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10490 53612 Ensembl ENSG00000100568 ENSMUSG00000021124 UniProt Q9UEU0 O88384 RefSeq (mRNA) NM_006370 NM_016800 NM_001364374 RefSeq (protein) NP_006361 n/a Location (UCSC) Chr 14: 67.65 – 67.67 Mb Chr 12: 79.2 – 79.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle transport through interaction with t-SNAREs homolog 1B is a protein that in humans is encoded by the VTI1B gene. ^{[5] [6] [7]}

Interactions

VTI1B has been shown to interact with STX8. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000100568 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021124 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li HC, Tahara H, Tsuyama N, Ide T (July 1998). "A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts". Biochem Biophys Res Commun. 247 (1): 70–4. doi:10.1006/bbrc.1998.8737. PMID   9636656.
6. Fischer von Mollard G, Stevens TH (February 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J Biol Chem. 273 (5): 2624–30. doi: 10.1074/jbc.273.5.2624 . PMID   9446565.
7. "Entrez Gene: VTI1B vesicle transport through interaction with t-SNAREs homolog 1B (yeast)".
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
9. Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (March 2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID   10683148.

Further reading

• Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID   10683148.
• Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2001). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC   305878 . PMID   11101518.
• Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi: 10.1074/jbc.M010838200 . PMID   11278762.
• Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. hdl: 11858/00-001M-0000-0012-F459-F . PMID   11786915. S2CID   17724790.
• Kreykenbohm V, Wenzel D, Antonin W, Atlachkine V, von Mollard GF (2003). "The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners". Eur. J. Cell Biol. 81 (5): 273–80. doi:10.1078/0171-9335-00247. hdl: 11858/00-001M-0000-0012-F3DF-D . PMID   12067063.
• Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R (2002). "The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly". J. Biol. Chem. 277 (39): 36449–56. doi: 10.1074/jbc.M204369200 . hdl: 11858/00-001M-0000-0012-F2E6-3 . PMID   12114520.
• Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC   1222979 . PMID   12175335.
• Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. Bibcode:2003PNAS..100.9011M. doi: 10.1073/pnas.1431910100 . PMC   166429 . PMID   12853575.
• Yan Q, Sun W, McNew JA, Vida TA, Bean AJ (2004). "Ca2+ and N-ethylmaleimide-sensitive factor differentially regulate disassembly of SNARE complexes on early endosomes". J. Biol. Chem. 279 (18): 18270–6. doi: 10.1074/jbc.M400093200 . PMID   14769786.
• Hirst J, Miller SE, Taylor MJ, von Mollard GF, Robinson MS (2005). "EpsinR is an adaptor for the SNARE protein Vti1b". Mol. Biol. Cell. 15 (12): 5593–602. doi:10.1091/mbc.E04-06-0468. PMC   532037 . PMID   15371541.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.