Grey's Anatomy season 21

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Contents

Grey's Anatomy
Season 21
Grey's Anatomy 21 poster.jpg
Promotional poster
ShowrunnerMeg Marinis
Starring
No. of episodes7
Release
Original network ABC
Original releaseSeptember 26, 2024 (2024-09-26) 
present (present)
Season chronology
 Previous
Season 20
List of episodes

The twenty-first season of the American medical drama television series Grey's Anatomy was announced on April 2, 2024, and premiered in the United States on the American Broadcasting Company (ABC) on September 26, 2024. [1]

Although announced as departing during the season, Jake Borelli and Midori Francis retain their series regular status. Both have been series regulars since the sixteenth and nineteenth seasons, respectively. [2] Jason George was repromoted as series regular following the conclusion of Station 19 . [3]

Cast and characters

Main

Recurring

Guest

Episodes

No.
overall
No. in
season
Title [6] Directed byWritten by [7] Original air date [6] U.S. viewers
(millions)
4311"If Walls Could Talk" Debbie Allen Meg MarinisSeptember 26, 2024 (2024-09-26)2.70 [8]
Meredith Grey and Catherine Fox are at odds over their Alzheimer’s research, with Catherine blocking Meredith’s efforts to secure outside funding. Jackson convinces Meredith to apologize for the greater good, but when she tries, Catherine collapses due to complications from her cancer, which has put her at risk of liver failure. Catherine makes a deal with Meredith: if she follows Catherine's wishes regarding her treatment and keeps her condition secret from Jackson and Richard, Meredith and her team can have their jobs back. Meanwhile, Bailey struggles with her recent firing and her dislike of her replacement, Sydney Heron. She grapples with whether to fight for her job and is inspired to do so after dealing with a patient trapped in the hospital walls. Lucas, torn between staying in Seattle or moving to Chicago, chooses love over career and stays to be with Simone, while fellow interns Jules and Mika confront their own romantic dilemma. Schmitt, facing a career crisis, receives advice from Link, who also learns Jo is pregnant. Webber reenters the OR, passing on valuable surgical knowledge to Winston.
4322"Take Me to Church" Kevin McKidd Michelle LirtzmanOctober 3, 2024 (2024-10-03)2.51 [9]
Catherine's health is deteriorating, and she's resisting medical help despite worsening signs of cancer, pushing away both Richard and Jackson. Meredith flies back to Seattle to monitor her, discovering liver lesions that may be cancerous. Enlisting Bailey, Meredith confronts Catherine's reluctance to pursue treatment. Catherine ultimately agrees to a biopsy after a heartfelt intervention from Bailey and Meredith. Meanwhile, Kwan is overwhelmed by the sudden return of his ex-fiancée Molly, who has amnesia. As they reconnect, painful memories resurface for Kwan, especially his guilt over her accident. He attempts to find closure, but an awkward kiss shows they’ve both moved on. Schmitt treats Cal, a teen battling multiple cancers due to Li-Fraumeni syndrome. After a successful surgery, Cal's condition worsens with a malignant brain tumor, leaving him just weeks to live. Schmitt, deeply moved, helps Cal create a bucket list, including a hopeful trip to space camp. Winston takes Richard and Adams golfing to help him rediscover his confidence in surgery. The day inspires Richard to reconsider stepping back, handing Teddy the Chief of Surgery role but signaling his return to the OR.
4333"I Can See Clearly Now" Victoria Mahoney Mark DriscollOctober 10, 2024 (2024-10-10)2.36 [10]
Catherine’s secret liver biopsy takes a dangerous turn, forcing Meredith and Bailey to act quickly. This leaves Richard blindsided and furious when he finds out about the deception. Meanwhile, Bailey navigates a career shift, with Catherine reinstating her as director of the residency program, removing Sydney from the position. Nick distracts Richard with an awake kidney transplant surgery, but tensions rise between Lucas and Simone as Lucas is chosen over her, which she thinks is nepotism. They resolve their conflict, reaffirming their relationship. In another case, Amelia takes on a risky surgery for a pregnant surrogate with a tumor, leading to intense debates in the OR. Amelia's decision echoes her late brother Derek’s legacy of tackling impossible cases. Levi flirts with Grey Sloan's chaplain, James, while handling a patient’s unconventional refusal to sign a DNR order until her ex-husband dies. Meanwhile, Yasuda breaks things off with Jules after she finds out her sister has been diagnosed with colon cancer.
4344"This One's for the Girls"Debbie AllenBriana BelserOctober 17, 2024 (2024-10-17)2.04 [11]
Mika's sister Chloe arrives at Grey Sloan Memorial for treatment of stage 3B colorectal cancer. Mika is deeply affected, feeling helpless despite being a surgeon. Determined to help, she explores fertility-saving procedures for Chloe. Jules steps in to emotionally support Chloe in the OR, while Mika's friends take over her shifts so she can be with her sister. Elsewhere, Ben Warren returns as a fourth-year surgical resident, encountering both support and challenges. He and Kwan work together to save a patient with a serious infection from a Brazilian butt lift. Ben’s return brings tension, especially with his wife, Miranda Bailey, who questions the impact of working together on their marriage. Owen and Teddy face marital issues, while Winston struggles with post-divorce frustrations and work stress. Schmitt begins a new relationship with James, the hospital chaplain, but uncovers a wedding album, uncovering deeper layers of James' past.
4355"You Make My Heart Explode" Vanessa Parise Zoanne Clack October 24, 2024 (2024-10-24)2.17 [12]
Schmitt and Adams face a dangerous helicopter transport with a critically injured young girl, Ofelia, whose leg is at risk without immediate care. Schmitt’s calm under pressure saves her, confirming his dedication to pediatric surgery—a career path Monica Beltran supports, even suggesting a clinical trial opportunity in Texas. Meanwhile, Jo Wilson, pregnant with twins, struggles with her anxieties, affecting her relationship with Link, who admits his own fears about parenthood. Bailey, Simone, and Kwan work tirelessly to secure costly gene therapy for Zayne, a hospital worker with severe sickle cell disease, though logistical barriers persist. Ndugu, invested in a lonely patient’s recovery, finds commonality with new resident Ben Warren. Elsewhere, Teddy and Owen continue couples therapy to salvage their marriage, debating between temporary fixes and genuine resolutions. When a surgery unexpectedly showers them in blood, the shock brings laughter and a shared moment, highlighting their determination to mend their relationship.
4366"Night Moves" Billie Woodruff Jase Miles-PerezNovember 7, 2024 (2024-11-07)2.04 [13]
The episode’s central case involves a scaffolding accident at an air guitar concert, where a teenage couple is rushed to the ER with serious injuries. Schmitt, now acting as an attending for the night under Bailey’s supervision, skillfully handles the complex trauma surgery, which includes a delicate decision to save a teen's kidney. Ultimately, Schmitt’s experiences with patients solidify his decision to accept the pediatric clinical research position in Texas despite offers to stay in Seattle as an attending. Meanwhile, Simone, who unintentionally confessed love to Lucas, ultimately embraces her feelings, leading to a reciprocal declaration of love from Adams. Yasuda’s fatigue reaches a critical point when, after assisting in a lung transplant, she falls asleep behind the wheel with her sister in the car, causing a crash. Wilson grapples with her fears of abandonment as her relationship with Link faces strain over her pregnancy; ultimately, Link reassures her that he is in it for the long haul. Altman finds herself in a complicated dynamic with new trauma surgeon Cass Beckman, whose marriage has recently opened up with nonmonogamy, leading to a surprising kiss. Altman ultimately tells Hunt, who is upset by this revelation.
4377"If You Leave" Allison Liddi-Brown Tameson DuffyNovember 14, 2024 (2024-11-14)2.13 [14]
4388"Drop It Like It's Hot"Kevin McKiddTBANovember 21, 2024 (2024-11-21)TBD

Production

Development

On April 2, 2024, ABC renewed the series for a twenty-first season with Meg Marinis returning as showrunner. On July 9, it was announced that the network had ordered 18 episodes for the season. [15] It premiered in the United States on September 26, 2024. [16]

Casting

Ahead of the twenty-first season, a number of long-term series regulars signed new contracts to return. Among these were two of three original cast members — Chandra Wilson and James Pickens Jr. — as well as others, including Kevin McKidd, Kim Raver, Caterina Scorsone, and Camilla Luddington. [17] As a cost-cutting measure, the number of episodes each of these series regular is entitled to in their contract, was reduced. [18] To further lower production costs, Jake Borelli who portrays Dr. Levi Schmitt and who joined the show in season 14, was announced to be departing the series. It was also reported that Midori Francis would be leaving the series after two years of portraying Dr. Mika Yasuda to pursue other opportunities. Both Borelli and Francis are set to appear in a limited number of episodes to provide closure to their characters storylines. [19] [20] Series regulars Chandra Wilson and James Pickens Jr. were also promoted to co-executive producers.

After starring in a reduced capacity across the previous two seasons, Ellen Pompeo is expected to increase her appearances, appearing in at least seven, but up to a maximum of fourteen, of the seasons episodes as the titular character, Dr. Meredith Grey. [21] Former series regular Scott Speedman is also set to see an increased presence in the season as Grey's love interest, Dr. Nick Marsh. He guest stars in at least five episodes. Speedman was part of the main cast for the eighteenth and nineteenth seasons, but was demoted to the recurring cast ahead of the previous season. [22] Following the conclusion of spin-off series Station 19 , Jason George returned to Grey's Anatomy as a series regular to portray Dr. Ben Warren. [23] George first appeared in the series in season 6 and was promoted to the main cast in season 12. He then left in season 14 to join Station 19 ensemble cast, where he remained for the entirety of that program's run. During this time, George continued to recur on Grey's Anatomy. [24]

Michael Thomas Grant was cast in a recurring role to portray an openly gay chaplain. [25] Kali Rocha also reprise her role in three episodes as Dr. Sydney Heron, after a 17-year absence in the series. Rocha originally recurred in eight episodes of the series across the second, third, and fourth seasons. [26]

Reception

Ratings

Viewership and ratings per episode of Grey's Anatomy season 21
No.TitleAir dateTimeslot (ET) Rating/share
(18–49)
Viewers
(millions)
DVR
(18–49)
DVR viewers
(millions)
Total
(18–49)
Total viewers
(millions)
1"If Walls Could Talk"September 26, 2024Thursday
10:00 p.m.
0.3/32.70 [8]
2"Take Me to Church"October 3, 20240.3/32.50 [9]
3"I Can See Clearly Now"October 10, 20240.2/32.36 [10]
4"This One's for the Girls"October 17, 20240.2/32.04 [11] 0.31.750.53.78 [11]
5"You Make My Heart Explode"October 24, 20240.2/32.17 [12] 0.21.710.43.88 [12]
6"Night Moves"November 7, 20240.2/22.04 [13]
7"If You Leave"November 14, 20240.2/22.13 [13]

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