Gtp binding protein 2

GTPBP2
Identifiers
Aliases	GTPBP2 , GTP binding protein 2
External IDs	OMIM: 607434 MGI: 1860138 HomoloGene: 10420 GeneCards: GTPBP2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,629,162 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,480,296 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; minor salivary gland; ; anterior pituitary; ; upper lobe of left lung; ; right lung; ; gastric mucosa; ; monocyte; ; body of pancreas; ; stromal cell of endometrium;
	Top expressed in
	motor neuron; ; lip; ; Paneth cell; ; pyloric antrum; ; ciliary body; ; fossa; ; superior frontal gyrus; ; condyle; ; substantia nigra; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ; GTPase activity ; translation elongation factor activity ;
Cellular component	intracellular membrane-bounded organelle ; extracellular region ; platelet alpha granule lumen ;
Biological process	platelet degranulation ; biological process ; translational elongation ;
	Sources:Amigo / QuickGO
Orthologs
	54676
	56055
	ENSG00000172432
	ENSMUSG00000023952
	Q9BX10
	Q3UJK4
	NM_019096 ; NM_001286216
	NM_001145979 ; NM_019581 ; NM_001357745
	NP_001273145 ; NP_061969 ; NP_061969.3
	NP_001139451 ; NP_062527 ; NP_001344674
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 01, 2023

GTP binding protein 2 is a protein that in humans is encoded by the GTPBP2 gene. ^[5]

Function

GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.

Related Research Articles

The G_s alpha subunit is a subunit of the heterotrimeric G protein G_s that stimulates the cAMP-dependent pathway by activating adenylyl cyclase. G_sα is a GTPase that functions as a cellular signaling protein. G_sα is the founding member of one of the four families of heterotrimeric G proteins, defined by the alpha subunits they contain: the G_αs family, G_αi/G_αo family, G_αq family, and G_α12/G_α13 family. The Gs-family has only two members: the other member is G_olf, named for its predominant expression in the olfactory system. In humans, G_sα is encoded by the GNAS complex locus, while G_olfα is encoded by the GNAL gene.

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.

Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

Ras-related protein Rab-26 is a protein that in humans is encoded by the RAB26 gene.

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.

Transcription factor AP-2 delta , also known as TFAP2D, is a human gene. The protein encoded by this gene is a transcription factor.

GTP binding protein 6 also known as GTPBP6 is a protein which in humans is encoded by the pseudoautosomal GTPBP6 gene.

Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the PLEKHG5 gene. Eight transcript variants encoding different isoforms have been found for this gene.

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.

Septin 14 is a protein that in humans is encoded by the SEPT14 gene.

Dmx-like 2 is a protein that in humans is encoded by the DMXL2 gene.

Guanylate binding protein family member 6 is a protein that in humans is encoded by the GBP6 gene.

Intraflagellar transport 27 is a protein that in humans is encoded by the IFT27 gene.

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene. G₁₄α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172432 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023952 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GTP binding protein 2" . Retrieved 2017-01-18.

Gtp binding protein 2

Contents

Function

Related Research Articles

References

Further reading