HECW1

HECW1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4H
Identifiers
Aliases	HECW1 , NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 610384 MGI: 2444115 HomoloGene: 9004 GeneCards: HECW1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,566,001 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	14,697,813 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; ganglionic eminence; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; pons; ; Brodmann area 9; ; parietal lobe;
	Top expressed in
	medial dorsal nucleus; ; facial motor nucleus; ; primary motor cortex; ; anterior horn of spinal cord; ; medial geniculate nucleus; ; medial vestibular nucleus; ; prefrontal cortex; ; trigeminal ganglion; ; lateral geniculate nucleus; ; spinal ganglia;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; ubiquitin-protein transferase activity ; ubiquitin protein ligase activity ;
Cellular component	cytosol ; cytoplasm ;
Biological process	negative regulation of canonical Wnt signaling pathway ; protein ubiquitination ; proteasome-mediated ubiquitin-dependent protein catabolic process ; protein polyubiquitination ; ubiquitin-dependent protein catabolic process ; positive regulation of protein catabolic process ; regulation of dendrite morphogenesis ; negative regulation of sodium ion transmembrane transporter activity ;
	Sources:Amigo / QuickGO
Orthologs
	23072
	94253
	ENSG00000002746
	ENSMUSG00000021301
	Q76N89
	Q8K4P8
	NM_001287059 ; NM_015052
	NM_001081348 ; NM_153130 ; NM_178809
	NP_001273988 ; NP_055867
	NP_001074817
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.^[5] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.^[6]

Related Research Articles

Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.

ITCH is a HECT domain E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 is an enzyme that is, in humans, encoded by the NEDD4 gene.

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 is an enzyme of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.

Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.

Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 is a protein that in humans is encoded by the HECW2 gene.

Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene.

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 gene.

RNF144A is an E3 ubiquitin ligase belonging to the RING-between RING (RBR) family of ubiquitin ligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases. RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins. The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000002746 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021301 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1".
↑ Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173 . PMID 27769290. Archived from the original on 2013-04-29. Retrieved 2020-01-06.

Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi: 10.1074/jbc.M312389200 . PMID 14684739.
Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1): e14583. Bibcode:2011PLoSO...614583C. doi: 10.1371/journal.pone.0014583 . PMC 3026782 . PMID 21283621.
Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995 . PMID 23535033.
Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi: 10.1038/sj.onc.1211032 . PMID 18223681.
Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi: 10.1074/jbc.C000906200 . PMID 11244092.
Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 1–7. doi: 10.1155/2011/831092 . PMC 2952905 . PMID 20976258.
Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294 . PMID 21572392.
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. hdl: 2115/44929 . PMID 21108931.
Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115 . PMID 24121790.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000002746 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021301 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1".

[Kozlowski-6] Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173 . PMID 27769290. Archived from the original on 2013-04-29. Retrieved 2020-01-06.

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HECW1

Related Research Articles

References

Further reading