HIST1H2BE

H2BC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC6 , H2B.h, H2B/h, H2BFH, dJ221C16.8, histone cluster 1, H2be, histone cluster 1 H2B family member e, HIST1H2BE, H2B clustered histone 6, H2BC10, H2BC8, H2BC7, H2BC4
External IDs	OMIM: 602805 MGI: 2448403 HomoloGene: 136773 GeneCards: H2BC6
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.2 Start 26,172,059 bp [1] End 26,184,655 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.1 Start 21,899,933 bp [2] End 21,900,313 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells right ventricle Achilles tendon oocyte thymus internal globus pallidus corpus epididymis bronchial epithelial cell amniotic fluid jejunal mucosa Top expressed in uterus spermatid bone marrow spermatocyte morula thymus secondary oocyte yolk sac blastocyst mesencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein heterodimerization activity identical protein binding Cellular component chromosome nucleosome extracellular exosome nucleus nucleoplasm extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8344 319185 Ensembl ENSG00000274290 ENSMUSG00000094338 UniProt P62807 P10853 RefSeq (mRNA) NM_003523 NM_178199 RefSeq (protein) NP_003517 NP_001368918 NP_835505 NP_001091448 NP_001300809 NP_001104025 NP_001300807 NP_835502 NP_835506 NP_835508 Location (UCSC) Chr 6: 26.17 – 26.18 Mb Chr 13: 21.9 – 21.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene. ^{[5] [6] [7]}

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000274290 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000094338 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID   9119399.
6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID   12408966.
7. "Entrez Gene: HIST1H2BE histone cluster 1, H2be".

Further reading

• Ohe Y, Hayashi H, Iwai K (1979). "Human spleen histone H2B. Isolation and amino acid sequence". J. Biochem. 85 (2): 615–24. doi:10.1093/oxfordjournals.jbchem.a132371. PMID   422550.
• Dobner T, Wolf I, Mai B, Lipp M (1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq. 1 (6): 409–13. doi:10.3109/10425179109020799. PMID   1768865.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID   9439656. S2CID   38539096.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC   110633 . PMID   9566873.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi: 10.1006/viro.2000.0593 . PMID   11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi: 10.1006/viro.2001.1129 . PMID   11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cheung WL, Ajiro K, Samejima K, et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell. 113 (4): 507–17. doi: 10.1016/S0092-8674(03)00355-6 . PMID   12757711. S2CID   21854.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC   291826 . PMID   14657027.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Golebiowski F, Kasprzak KS (2007). "Inhibition of core histones acetylation by carcinogenic nickel(II)". Mol. Cell. Biochem. 279 (1–2): 133–9. doi:10.1007/s11010-005-8285-1. PMID   16283522. S2CID   25071586.
• Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi: 10.1016/j.molcel.2005.09.025 . PMID   16307923.
• Bonenfant D, Coulot M, Towbin H, et al. (2006). "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry". Mol. Cell. Proteomics. 5 (3): 541–52. doi: 10.1074/mcp.M500288-MCP200 . PMID   16319397.
• Beck HC, Nielsen EC, Matthiesen R, et al. (2006). "Quantitative proteomic analysis of post-translational modifications of human histones". Mol. Cell. Proteomics. 5 (7): 1314–25. doi: 10.1074/mcp.M600007-MCP200 . PMID   16627869.
• Pavri R, Zhu B, Li G, et al. (2006). "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II". Cell. 125 (4): 703–17. doi: 10.1016/j.cell.2006.04.029 . PMID   16713563. S2CID   2614680.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi: 10.1016/j.molcel.2006.06.026 . PMID   16916647.