HLA-DR17

Last updated
DR Illustration.PNG
major histocompatibility complex, class II, DR17
Haplotypes groupsDRA*01:DRB1*0301 DRA*01:DRB1*0304
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA [ permanent dead link ]
EBI-HLA DRA*0101
Identifiers
beta 1 *0301*0304
Symbol(s) HLA-DRB1 [ permanent dead link ]
EBI-HLA DRB1*0301
EBI-HLA DRB1*0304
Shared data
Locus chr.6 6p21.31

HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.

Contents

Serology

DR17 and DR3 recognition of some DRB1*03 alleles [1]
DRB1*DR17DR3DR18Sample
allele % % %size (N)
0301643309698
030420605

DR17 recognizes the DRB1*0301, *0304 alleles.

Disease associations

By serotype

DR17 is associated with non-chronic sarcoidosis, [2] [3] infantile spasm/epilepsy, [4] rabies vaccine-induced autoimmune encephalomyelitis [5] and cardiovascular hypertrophy in subjects with arterial hypertension [6] People with DR17 show a tendency toward benzylpenicilloyl allergies. [7]

By allele

DRB1*0301: diabetes mellitus type 1, [8] myositis, [9] early onset Graves disease, [10] type 1 autoimmune hepatitis, [11] inflammatory inclusion body myositis. [12] In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease. [13]

By haplotype

DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1, [14] ovarian cancer, [15] non-thymomic myasthenia gravis, [16] idiopathic inflammatory myopathies, [17] non-cancer associated Lambert-Eaton myasthenic syndrome [18] and sarcoidosis [19]

By phenotype

The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome [20]

Genetic Linkage

DR17 Haplotypes
SerotypesDRADRB1DRB3
DR17*0101*03010101
*0101*03010201
SerotypesDQA1DQB1DRB1
DR17(3)-DQ2(2.5)*0501*0201*0301
SerotypesHLA-AHLA CHLA BDRB1
A1-Cw7-B8-DR17(3)*0101*0701*0801*0301
A2-Cw7-B8-DR17(3)*0201*0701*0801*0301
A30-Cw5-B18-DR17(3)*3002*0501*1801*0301

HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:

A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201

This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"

Related Research Articles

HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored.

<span class="mw-page-title-main">HLA-DQ8</span>

HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.

<span class="mw-page-title-main">HLA-DQ2</span>

HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles, DQB1*0201 and DQB1*0202. HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA1*0201 and DQA1*0501 genes, respectively.

<span class="mw-page-title-main">HLA-DQ4</span>

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.

<span class="mw-page-title-main">HLA-DQ5</span>

HLA-DQ5 (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1 encoded by the DQA1*01 allele group.

<span class="mw-page-title-main">HLA-DQ6</span>

HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently contains many common alleles, DQB1*0602 is the most common. HLA-DQ6 and DQB1*06 are almost synonymous in meaning. DQ6 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains. There are many haplotypes of DQ6.

<span class="mw-page-title-main">HLA-DQ9</span>

HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.

<span class="mw-page-title-main">HLA-DQ7</span>

HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR52</span>

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.

<span class="mw-page-title-main">HLA-DR18</span>

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

<span class="mw-page-title-main">HLA-DR15</span>

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

<span class="mw-page-title-main">HLA-DR11</span>

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

<span class="mw-page-title-main">HLA-DR12</span>

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

<span class="mw-page-title-main">HLA-DR3</span>

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4, yet only a small percentage of these individuals will develop type 1 diabetes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

<span class="mw-page-title-main">HLA-B7</span>

HLA-B7 (B7) is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products. B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.

<span class="mw-page-title-main">HLA-B45</span>

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.

HLA A1-B8-DR3-DQ2 haplotype is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are generally the result of descent by common ancestry. Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations.

HLA B7-DR15-DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles, common multigene haplotypes are generally the result of descent by common ancestry. Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ Berlin M, Fogdell-Hahn A, Olerup O, Eklund A, Grunewald J (1997). "HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis". Am J Respir Crit Care Med. 156 (5): 1601–5. doi:10.1164/ajrccm.156.5.9704069. PMID   9372682.
  3. ↑ Planck A, Katchar K, Eklund A, Gripenbäck S, Grunewald J (2003). "T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis". Sarcoidosis Vasc Diffuse Lung Dis. 20 (2): 110–7. PMID   12870720.
  4. ↑ Suastegui R, De La Rosa G, Carranza J, Gonzalez-Astiazaran A, Gorodezky C (2001). "Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos". Epilepsia. 42 (2): 210–5. doi: 10.1046/j.1528-1157.2001.22700.x . PMID   11240591.
  5. ↑ Piyasirisilp S, Schmeckpeper B, Chandanayingyong D, Hemachudha T, Griffin D (1999). "Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis". Ann Neurol. 45 (5): 595–600. doi:10.1002/1531-8249(199905)45:5<595::AID-ANA7>3.0.CO;2-M. PMID   10319881. S2CID   28870098.
  6. ↑ Diamantopoulos E, Andreadis E, Vassilopoulos C, Vlachonikolis I, Tarassi K, Chatzis N, Giannakopoulos N, Papasteriades C (2001). "Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives". Am J Hypertens. 14 (7 Pt 1): 632–6. doi: 10.1016/S0895-7061(01)01283-3 . PMID   11465646.
  7. ↑ Yang J, Qiao HL, Zhang YW, Jia LJ, Tian X, Gao N (2006). "HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins". Chin. Med. J. 119 (6): 458–66. doi: 10.1097/00029330-200603020-00005 . PMID   16584643.
  8. ↑ Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratisl Lek Listy. 107 (3): 76–9. PMID   16796128.
  9. ↑ O'Hanlon T, Carrick D, Targoff I, Arnett F, Reveille J, Carrington M, Gao X, Oddis C, Morel P, Malley J, Malley K, Shamim E, Rider L, Chanock S, Foster C, Bunch T, Blackshear P, Plotz P, Love L, Miller F (2006). "Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies". Medicine (Baltimore). 85 (2): 111–27. doi:10.1097/01.md.0000217525.82287.eb. PMID   16609350. S2CID   25224623.
  10. ↑ Lavard L, Madsen H, Perrild H, Jacobsen B, Svejgaard A (1997). "HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype". Tissue Antigens. 50 (6): 639–41. doi:10.1111/j.1399-0039.1997.tb02922.x. PMID   9458117.
  11. ↑ Czaja A, Strettell M, Thomson L, Santrach P, Moore S, Donaldson P, Williams R (1997). "Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis". Hepatology. 25 (2): 317–23. doi:10.1002/hep.510250211. PMID   9021941.
  12. ↑ Sivakumar K, Semino-Mora C, Dalakas M (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain. 120 (4): 653–61. doi:10.1093/brain/120.4.653. PMID   9153127.
  13. ↑ Montano Loza AJ, Czaja AJ (2007). "Current therapy for autoimmune hepatitis". Nature Clinical Practice Gastroenterology & Hepatology. 4 (4): 202–14. doi:10.1038/ncpgasthep0768. PMID   17404588. S2CID   24280843.
  14. ↑ Deja G, Jarosz-Chobot P, Polańska J, Siekiera U, Małecka-Tendera E (2006). "Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?". Mediators Inflamm. 2006 (4): 1–7. doi: 10.1155/MI/2006/19724 . PMC   1618952 . PMID   17047287.
  15. ↑ Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian cancer". Int J Cancer. 119 (12): 2980–5. doi: 10.1002/ijc.22266 . PMID   17016821.
  16. ↑ Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, Izbicki J (1999). "Correlation of thymic pathology with HLA in myasthenia gravis". Clinical Immunology. 91 (3): 296–301. doi:10.1006/clim.1999.4710. PMID   10370374.
  17. ↑ Shamim E, Rider L, Miller F (2000). "Update on the genetics of the idiopathic inflammatory myopathies". Curr Opin Rheumatol. 12 (6): 482–91. doi:10.1097/00002281-200011000-00002. PMID   11092196.
  18. ↑ Parsons K, Kwok W, Gaur L, Nepom G (2000). "Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer". Hum Immunol. 61 (8): 828–33. doi:10.1016/S0198-8859(00)00135-X. PMID   10980394.
  19. ↑ Grubić R, Žunec T, Peroš-Golubičić J, et al. (2007). "HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1*0201 haplotype in clinical variations of the disease". Tissue Antigens. 70 (4): 301–6. doi:10.1111/j.1399-0039.2007.00904.x. PMID   17767551.
  20. ↑ Jean S, Quelvennec E, Alizadeh M, Guggenbuhl P, Birebent B, Perdriger A, Grosbois B, Pawlotsky P, Semana G (1998). "DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility". Clin Exp Rheumatol. 16 (6): 725–8. PMID   9844767.
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