HLA-DR12

Last updated
DR Illustration.PNG
major histocompatibility complex, class II, DR12
Haplotypes groupsDQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA [ permanent dead link ]
EBI-HLA DRA*0101
Identifiers
beta 1 *1201 to *1203*1206
Symbol(s) HLA-DRB1 [ permanent dead link ]
EBI-HLA DRB1*1201
EBI-HLA DRB1*1202 Archived 2011-05-15 at the Wayback Machine
EBI-HLA DRB1*1203 Archived 2011-05-15 at the Wayback Machine
EBI-HLA DRB1*1306
Shared data
Locus chr.6 6p21.31

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

Contents

Serology

DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles [1]
DRB1*DR12DR5DR11Sample
allele % % %size (N)
12018342893 [2]
120289162
1203>503
1206>502

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus, [3] and undifferentiated spondyloarthritis. [4]

DRB1*1201 is associated with iritis in juvenile arthritis, [5] primary antiphospholipid syndrome, [6] tiopronin intolerance in rheumatoid arthritis, [7] adult chronic articular Still's disease [8]

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, [9] and narcolepsy in the Japanese population.

Extended linkage

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease [10]

DRB1*1201:DRB3*01/03: colorectal cancer [11]

Genetic Linkage

DR12 Haplotypes
SerotypesDRADRB1DRB3
DR11(5)-DR52 *0101*1201*0101
*0101*1202*0201
*0101*1202*0202
*0101*1202*0301
SerotypesDRB1DQA1DQB1
DR12(5)-DQ7 (7.5, 3)*1201*0505*0301
*1202*0505*0301
DR12(5)-DQ7 (7.3, 3)*1201*0303*0301
DR12(5)-DQ7 (7.4, 3)*1201*0401*0301
DR12(5)-DQ7 (7.6, 3)*1201*0601*0301
Serotypes HLA-A HLA-C HLA-B DRB1
A31(19)-Cw10-B51(5)-DR12(5)*3101*0304*5101*1202
A11-Cw9-B75(15)-DR12(5)*1101*0303*1502*1202
A2-Cw10-B13-DR12(5)*0201*0304*1301*1202

HLA-DR12 is genetically linked to DR52 [12] and HLA-DQ7 serotypes.

Related Research Articles

<span class="mw-page-title-main">Human leukocyte antigen</span> Genes on human chromosome 6

The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

<span class="mw-page-title-main">HLA-DQ7</span>

HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.

<span class="mw-page-title-main">HLA-DR53</span>

HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.

<span class="mw-page-title-main">HLA-DR52</span>

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.

<span class="mw-page-title-main">HLA-DR51</span>

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

<span class="mw-page-title-main">HLA-DR17</span>

HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe. DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.

<span class="mw-page-title-main">HLA-DR15</span>

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

<span class="mw-page-title-main">HLA-DR13</span>

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

<span class="mw-page-title-main">HLA-DR14</span>

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

<span class="mw-page-title-main">HLA-DR11</span>

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

<span class="mw-page-title-main">HLA-DR10</span>

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

<span class="mw-page-title-main">HLA-DR8</span>

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

<span class="mw-page-title-main">HLA-DR7</span>

HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products.

<span class="mw-page-title-main">HLA-DR5</span>

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

<span class="mw-page-title-main">HLA-DR2</span> Antigen serotype

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

<span class="mw-page-title-main">HLA-DR3</span>

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4, yet only a small percentage of these individuals will develop type 1 diabetes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

<span class="mw-page-title-main">HLA-DR1</span>

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.

In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. As a result AAHA are strongly implicated in autoimmune deep vein thrombosis.

<span class="mw-page-title-main">HLA-B39</span>

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ DR8 - 2%
  3. ↑ Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus". J Invest Dermatol. 125 (5): 895–9. doi: 10.1111/j.0022-202X.2005.23905.x . PMID   16297186.
  4. ↑ Liao HT, Lin KC, Chen CH, et al. (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". Seminars in Arthritis and Rheumatism. 37 (3): 198–201. doi:10.1016/j.semarthrit.2007.04.004. PMID   17604825.
  5. ↑ Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children". J Rheumatol. 21 (1): 159–64. PMID   8151573.
  6. ↑ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. doi:10.1002/art.1780380925. PMID   7575732.
  7. ↑ Ju LY, Paolozzi L, Delecoeuillerie G, et al. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (3): 249–54. PMID   7915222.
  8. ↑ Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease". Rheumatology (Oxford). 40 (12): 1398–404. doi: 10.1093/rheumatology/40.12.1398 . PMID   11752512.
  9. ↑ Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health. 37 (2): 357–65. PMID   17124999.
  10. ↑ Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population". Tissue Antigens. 40 (2): 90–7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID   1357780.
  11. ↑ Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population". Hum Immunol. 34 (1): 19–23. doi:10.1016/0198-8859(92)90080-7. PMID   1356954.
  12. ↑ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID   15041167.
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