HLA-DR16

Last updated

DR Illustration.PNG
major histocompatibility complex, class II, DR16
Haplotypes groupsDRA*01:DRB1*1601 DRA*01:DRB1*1602
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA [ permanent dead link ]
EBI-HLA DRA*0101
Identifiers
beta 1 *1601*1602*1604
Symbol(s) HLA-DRB1 [ permanent dead link ]
EBI-HLA DRB1*1601
EBI-HLA DRB1*1602
EBI-HLA DRB1*1604
Shared data
Locus chr.6 6p21.31

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

Contents

Alleles

DR16, DR2 and other serotype recognition of some DRB1*16 alleles [1]
DRB1*DR16DR2DR15Sample
allele % % %size (N)
1601412919703
1602473016239
1604>501

Disease associations

DR16 is associated with Chaga's cardiomyopathy, [2] rheumatic heart disease, [3] coronary artery ectasia, [4] and chronic discoid lupus erythematosus. [5]

DRB1*1601 is associated with tuberculosis risk [6]

DRB1*1602: Juvenile rheumatoid arthritis, [7] rheumatic heart disease, [3] Takayasu arteritis Archived 2007-08-07 at the Wayback Machine , [8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody, [9] [10] melioidosis (Burkholderia pseudomallei infection) [11]

Extended linkage

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]

Genetic Linkage

DR16 Haplotypes
SerotypesDRADRB1DRB5
DR16(2)-DR51*0101*1601*0101
*0101*1602*0101
*0101*1604*0101
DQA1DQB1DRB1
DR16(2)-DQ5 (5.2, 1)*0102*0502*1601
HLA-AHLA-BDRB1
A2-B51(5)-DR16(2)*0201*5101*1601

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ Cruz-Robles D, Reyes P, Monteón-Padilla V, Ortiz-Muñiz A, Vargas-Alarcón G (2004). "MHC class I and class II genes in Mexican patients with Chagas disease". Hum Immunol. 65 (1): 60–5. doi:10.1016/j.humimm.2003.10.008. PMID   14700597.
  3. 1 2 3 Hernández-Pacheco G, Aguilar-García J, Flores-Domínguez C, Rodríguez-Pérez J, Pérez-Hernández N, Alvarez-Leon E, Reyes P, Vargas-Alarcón G (2003). "MHC class II alleles in Mexican patients with rheumatic heart disease". Int J Cardiol. 92 (1): 49–54. doi:10.1016/S0167-5273(03)00040-8. PMID   14602216.
  4. ↑ Akdemir R, Ozhan H, Gunduz H, Erbilen E, Yazici M, Duran S, Orkunoglu F, Albayrak S, Imirzalioglu N, Uyan C (2004). "HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia". Acta Cardiol. 59 (5): 499–502. doi:10.2143/AC.59.5.2005222. hdl: 20.500.12684/6176 . PMID   15529553. S2CID   25040717.
  5. ↑ López-Tello A, Rodríguez-Carreón AA, Jurado F, et al. (2007). "Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients". Clin. Exp. Dermatol. 32 (4): 435–8. doi:10.1111/j.1365-2230.2007.02391.x. PMID   17376212. S2CID   19569740.
  6. 1 2 Dubaniewicz A, Moszkowska G, Szczerkowska Z (2005). "Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report". Tuberculosis (Edinb). 85 (4): 259–67. doi:10.1016/j.tube.2004.12.003. PMID   15958261.
  7. ↑ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID   15120191.
  8. ↑ Salazar M, Varela A, Ramirez L, Uribe O, Vasquez G, Egea E, Yunis E, Iglesias-Gamarra A (2000). "Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry". Int J Cardiol. 75 (Suppl 1): S113–6. doi:10.1016/s0167-5273(00)00181-9. PMID   10980348.
  9. ↑ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi: 10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y . PMID   10088769.
  10. 1 2 Tan F, Stivers D, Arnett F, Chakraborty R, Howard R, Reveille J (1999). "HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)". Tissue Antigens. 53 (1): 74–80. doi: 10.1034/j.1399-0039.1999.530108.x . PMID   10082433.
  11. ↑ Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S (1998). "HLA-DR and -DQ associations with melioidosis". Hum Immunol. 59 (9): 580–6. doi:10.1016/S0198-8859(98)00052-4. PMID   9757914.
  12. ↑ Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N (2006). "The association between HLA class II haplotype with Graves' disease in Thai population". Tissue Antigens. 67 (1): 79–83. doi:10.1111/j.1399-0039.2005.00498.x. PMID   16451208.
  13. ↑ Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease in Koreans". Hum Immunol. 66 (6): 741–7. doi:10.1016/j.humimm.2005.03.001. PMID   15993720.
  14. ↑ Cervantes J, Lema C, Valentina Hurtado L, Andrade R, Hurtado Gomez L, Torrico L, Zegarra L, Quiroga G, Asturizaga D, Dulon A, Prada R, Panoso W, Yashiki S, Fujiyoshi T, Sonoda S (2003). "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890–5. doi:10.1016/S0198-8859(03)00163-0. PMID   12941545.
  15. ↑ Arnett F, Howard R, Tan F, Moulds J, Bias W, Durban E, Cameron H, Paxton G, Hodge T, Weathers P, Reveille J (1996). "Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype". Arthritis Rheum. 39 (8): 1362–70. doi:10.1002/art.1780390814. PMID   8702445.
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