HLA-DR5

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Illustration of HLA-DR DR Illustration.PNG
Illustration of HLA-DR

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Contents

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles [1]
DRB1*DR11DR5DR12Sample
allele % % %size (N)
11:019253474
11:02893430
11:03894397
11:048742119
11:05754
11:06207315
11:07>501
11:08>502
11:0980205
.
DR12DR5DR11Sample
12:018342893 [2]
12:0289162
12:03>503
12:06>502

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy [3] and Kaposi's sarcoma in AIDS, [4] juvenile rheumatoid arthritis, [5] [6] pernicious anemia, Hashimoto's thyroiditis, [7] [8] mycosis fungoides, [9] polyglandular deficiency syndrome, [10] systemic sclerosis, [11] [12] childhood epilepsy, [13] early-onset alopecia areata, [14] short-ragweed Ra6 allergy, [15] primary antiphospholipid syndrome, [16] and increased longevity in the Dutch. [17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

Related Research Articles

HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored.

<span class="mw-page-title-main">HLA-DQ8</span>

HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR53</span>

HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.

<span class="mw-page-title-main">HLA-DR52</span>

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.

<span class="mw-page-title-main">HLA-DR17</span>

HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe. DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.

<span class="mw-page-title-main">HLA-DR16</span>

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

<span class="mw-page-title-main">HLA-DR15</span>

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

<span class="mw-page-title-main">HLA-DR11</span>

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

<span class="mw-page-title-main">HLA-DR12</span>

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

<span class="mw-page-title-main">HLA-DR2</span> Antigen serotype

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

<span class="mw-page-title-main">HLA-DR3</span>

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4, yet only a small percentage of these individuals will develop type 1 diabetes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

<span class="mw-page-title-main">HLA-DR1</span>

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.

<span class="mw-page-title-main">HLA-A33</span>

HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α33 subset of HLA-A α-chains. For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 are almost synonymous in meaning. A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74.

HLA-B47 (B47) is an HLA–B serotype. The serotype identifies the HLA-B*47 gene products. Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event. B47 is linked to a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa.

<span class="mw-page-title-main">HLA-DPB1</span> Protein-coding gene in the species Homo sapiens

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

<span class="mw-page-title-main">HLA-B39</span>

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.

<span class="mw-page-title-main">HLA-B45</span>

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.

HLA B7-DR15-DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles, common multigene haplotypes are generally the result of descent by common ancestry. Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ DR8 - 2%
  3. ↑ Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J (1987). "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia". Tissue Antigens. 29 (1): 60–2. doi:10.1111/j.1399-0039.1987.tb01550.x. PMID   3495904.
  4. ↑ Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B (1983). "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma". Tissue Antigens. 21 (1): 1–8. doi:10.1111/j.1399-0039.1983.tb00364.x. PMID   6601312.
  5. ↑ Førre O, Dobloug J, Høyeraal H, Thorsby E (1983). "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes". Arthritis Rheum. 26 (1): 35–8. doi:10.1002/art.1780260106. PMID   6401993.
  6. ↑ Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C (1980). "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints". Lancet. 2 (8184): 40. doi:10.1016/S0140-6736(80)92920-7. PMID   6104257. S2CID   40329624.
  7. ↑ Farid N, Sampson L, Moens H, Barnard J (1981). "The association of goitrous autoimmune thyroiditis with HLA-DR5". Tissue Antigens. 17 (3): 265–8. doi:10.1111/j.1399-0039.1981.tb00700.x. PMID   6947505.
  8. ↑ Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter". J Clin Endocrinol Metab. 56 (4): 781–5. doi:10.1210/jcem-56-4-781. PMID   6131902.
  9. ↑ Safai B, Myskowski P, Dupont B, Pollack M (1983). "Association of HLA-DR5 with mycosis fungoides". J Invest Dermatol. 80 (5): 395–7. doi: 10.1111/1523-1747.ep12553615 . PMID   6601679.
  10. ↑ Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L (1987). "The polyglandular deficiency syndrome: a new variant in Persian Jews". J Endocrinol Invest. 10 (1): 1–7. doi:10.1007/bf03347139. PMID   3496374. S2CID   33773103.
  11. ↑ Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N (1987). "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families". J Rheumatol. 14 (4): 760–5. PMID   3499513.
  12. ↑ Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E (1987). "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles". Arch Dermatol. 123 (9): 1188–91. doi:10.1001/archderm.123.9.1188. PMID   3498440.
  13. ↑ Minev M, Martinova F, Belopitova L (1987). "On the association of the HLA system with epilepsy in children". Epilepsia. 28 (1): 74–6. doi:10.1111/j.1528-1157.1987.tb03626.x. PMID   3098558. S2CID   12471018.
  14. ↑ Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G (1987). "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata". Dermatologica. 175 (1): 10–4. doi:10.1159/000248775. PMID   3497062.
  15. ↑ Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M (1987). "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans". Immunogenetics. 26 (4–5): 230–6. doi: 10.1007/BF00346517 . PMID   3498688. S2CID   25679118.
  16. ↑ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. doi: 10.1002/art.1780380925 . PMID   7575732.
  17. ↑ Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W (1991). "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci. 621: 78–89. doi:10.1111/j.1749-6632.1991.tb16970.x. PMID   1859103. S2CID   83560622.
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