HLA-DR11

Last updated
DR Illustration.PNG
major histocompatibility complex, class II, DR11
Haplotypes groupsDQA*01:DRB1*1101 to DQA*01:DRB1*1111
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA [ permanent dead link ]
EBI-HLA DRA*0101
Identifiers
beta 1 *1101 to *1110
Symbol(s) HLA-DRB1 [ permanent dead link ]
EBI-HLA DRB1*1101
EBI-HLA DRB1*1102
EBI-HLA DRB1*1103 Archived 2011-05-15 at the Wayback Machine
EBI-HLA DRB1*1104
EBI-HLA DRB1*1105
EBI-HLA DRB1*1106
Shared data
Locus chr.6 6p21.31

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

Contents

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 alleles [1]
DRB1*DR11DR5DR12Sample
allele % % %size (N)
11019253474
1102893430
1103894397
11048742119
1105754
1106207315
1107>501
1108>502
110980205

The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157

Disease associations

By serotype

DR11 is associated with grape anaphylaxis, [2] well-differentiated thyroid cancer, [3] low antibody production in Hepatitis C. [4]

By allele(s)

DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody [5]

DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, [6] mite sensitive asthma, [7] cervical cancer risk (HPV?) [8]

DRB1*1102: Tiopronin intolerance in rheumatoid arthritis [9]

DRB1*1104: pauciarticular juvenile rheumatoid arthritis [10]

By haplotype

DR11 is an identifier for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease. [11] DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease. [12]

DRB1*1101:DQA1*0505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, [6] mite sensitive asthma [7]

DRB1*1102:DQA1*0505:DQB1*0301 haplotype is associated with hepatitis B virus persistence [13]

Genetic Linkage

DR11 Haplotypes
SerotypesDRADRB1DRB3
DR11(5)-DR52 *0101*1101*02
*0101*1102*02
*0101*1103*02
*0101*1104*02
SerotypesDRB1DQA1DQB1
DR11(5)-DQ7 (7.5, 3)*1101*0505*0301
*1102*0505*0301
*1103*0505*0301
*1104*0505*0301
Serotypes HLA-A HLA-C HLA-B DRB1
A2-Cw7-B18-DR11*0201*0701*1801*1104
A24(9)-Cw4-B35-DR11*2402*0401*3501*1101
A24(9)-Cw14(BL)-B51(5)-DR11*2402*1402*5101*1104

HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) serotypes. The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.

Related Research Articles

<span class="mw-page-title-main">Human leukocyte antigen</span> Genes on human chromosome 6

The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored.

<span class="mw-page-title-main">HLA-DQ8</span>

HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.

<span class="mw-page-title-main">HLA-DQ2</span>

HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles, DQB1*0201 and DQB1*0202. HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA1*0201 and DQA1*0501 genes, respectively.

<span class="mw-page-title-main">HLA-DQ4</span>

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.

<span class="mw-page-title-main">HLA-DQ5</span>

HLA-DQ5 (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1 encoded by the DQA1*01 allele group.

<span class="mw-page-title-main">HLA-DQ6</span>

HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently contains many common alleles, DQB1*0602 is the most common. HLA-DQ6 and DQB1*06 are almost synonymous in meaning. DQ6 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains. There are many haplotypes of DQ6.

<span class="mw-page-title-main">HLA-DQ9</span>

HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.

<span class="mw-page-title-main">HLA-DQ7</span>

HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR17</span>

HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe. DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.

<span class="mw-page-title-main">HLA-DR16</span>

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

<span class="mw-page-title-main">HLA-DR15</span>

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

<span class="mw-page-title-main">HLA-DR14</span>

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

<span class="mw-page-title-main">HLA-DR12</span>

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

<span class="mw-page-title-main">HLA-DR10</span>

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

<span class="mw-page-title-main">HLA-DR3</span>

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4, yet only a small percentage of these individuals will develop type 1 diabetes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. As a result AAHA are strongly implicated in autoimmune deep vein thrombosis.

<span class="mw-page-title-main">HLA-B45</span>

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ Kalogeromitros D, Makris M, Gregoriou S, Mousatou V, Lyris N, Tarassi K, Papasteriades C (2005). "Grape anaphylaxis: a study of 11 adult onset cases". Allergy Asthma Proc. 26 (1): 53–8. PMID   15813289.
  3. ↑ Juhasz F, Kozma L, Stenszky V, Gyory F, Luckas G, Farid N (2005). "Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D-related 11 in Eastern Hungarians: a case of changing circumstances". Cancer. 104 (8): 1603–8. doi: 10.1002/cncr.21382 . PMID   16121403.
  4. ↑ Hu C, Wu C, Lee C, Wu C, Tsai H, Chen P, Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C." Ann Rheum Dis. 65 (1): 138–9. doi:10.1136/ard.2005.039982. PMC   1797994 . PMID   16344504.
  5. ↑ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi: 10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y . PMID   10088769.
  6. 1 2 Miyagawa S, Shinohara K, Kidoguchi K, Fujita T, Fukumoto T, Hashimoto K, Yoshioka A, Shirai T (1997). "Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers". Autoimmunity. 26 (2): 95–101. doi:10.3109/08916939709003852. PMID   9546818.
  7. 1 2 Lara-Marquez M, Yunis J, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze N, Pocino M, Granja C, Yunis E (1999). "Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population". Clin Exp Allergy. 29 (1): 60–71. doi:10.1046/j.1365-2222.1999.00461.x. PMID   10051703. S2CID   32816835.
  8. ↑ Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565–74. doi: 10.1086/345285 . PMID   12447731.
  9. ↑ Ju L, Paolozzi L, Delecoeuillerie G, Bourgeois P, Khodja M, Legoff P, Liote F, Sheffer V, Amor B, Charron D (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin Exp Rheumatol. 12 (3): 249–54. PMID   7915222.
  10. ↑ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID   15120191.
  11. ↑ Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population". Tissue Antigens. 40 (2): 90–7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID   1357780.
  12. ↑ Chou HT, Chen CH, Chen JY, Chang KC (2007). "Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan". International Journal of Cardiology. 128 (3): 434–5. doi:10.1016/j.ijcard.2007.06.032. PMID   17673320.
  13. ↑ Thio C, Carrington M, Marti D, O'Brien S, Vlahov D, Nelson K, Astemborski J, Thomas D (1999). "Class II HLA alleles and hepatitis B virus persistence in African Americans". J Infect Dis. 179 (4): 1004–6. doi: 10.1086/314684 . PMID   10068598.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.