HLTF

HLTF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MZN, 4HRE, 4HRH, 4S0N, 4XZF, 4XZG, 5BNH, 5K5F
Identifiers
Aliases	HLTF , HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1, helicase-like transcription factor, helicase like transcription factor
External IDs	OMIM: 603257; MGI: 1196437; HomoloGene: 30136; GeneCards: HLTF; OMA:HLTF - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q24 Start 149,030,127 bp [1] End 149,086,554 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 A2|3 6.15 cM Start 20,111,975 bp [2] End 20,172,654 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pons lateral nuclear group of thalamus pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular nucleus external globus pallidus cerebellar vermis Top expressed in saccule otic placode otic vesicle habenula atrioventricular valve transitional epithelium of urinary bladder mesenteric lymph nodes retinal pigment epithelium blood primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity protein binding catalytic activity nucleic acid binding hydrolase activity ATP binding ubiquitin protein ligase binding transferase activity RNA binding ubiquitin protein ligase activity Cellular component cytoplasm membrane nucleolus nucleus nucleoplasm Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated metabolism positive regulation of transcription by RNA polymerase II protein ubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6596 20585 Ensembl ENSG00000071794 ENSMUSG00000002428 UniProt Q14527 Q6PCN7 RefSeq (mRNA) NM_003071 NM_139048 NM_001318934 NM_001318935 NM_009210 NM_144959 NM_001355097 RefSeq (protein) NP_001305863 NP_001305864 NP_003062 NP_620636 NP_033236 NP_001342026 Location (UCSC) Chr 3: 149.03 – 149.09 Mb Chr 3: 20.11 – 20.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene. ^{[5] [6]}

Function

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. ^[6]

HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae RAD5 besides SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5. ^[7]

Interactions

HLTF has been shown to interact with UBE2N, ^[8] RAD18 ^[8] and UBE2V2 ^[8] (see also STRING functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->' ).

References

1. GRCh38: Ensembl release 89: ENSG00000071794 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002428 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lin Y, Sheridan PL, Jones KA, Evans GA (Nov 1995). "The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1". Genomics. 27 (2): 381–2. doi:10.1006/geno.1995.1064. PMID   7558014.
6. "Entrez Gene: HLTF helicase-like transcription factor".
7. Unk I, Hajdú I, Blastyák A, Haracska L (Jan 2010). "Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance". DNA Repair (Amst). 9 (3): 257–67. doi:10.1016/j.dnarep.2009.12.013. PMID   20096653.
8. Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L (March 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3768–73. Bibcode:2008PNAS..105.3768U. doi: 10.1073/pnas.0800563105 . PMC   2268824 . PMID   18316726.

Further reading

• Sheridan PL, Schorpp M, Voz ML, Jones KA (1995). "Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter". J. Biol. Chem. 270 (9): 4575–87. doi: 10.1074/jbc.270.9.4575 . PMID   7876228.
• Descheemaeker K (1993). "On the regulation of the plasminogen activator inhibitor-1 gene expression". Verh. K. Acad. Geneeskd. Belg. 55 (3): 225–64. PMID   8342330.
• Ding H, Descheemaeker K, Marynen P, et al. (1996). "Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene". DNA Cell Biol. 15 (6): 429–42. doi:10.1089/dna.1996.15.429. PMID   8672239.
• Gong X, Kaushal S, Ceccarelli E, et al. (1997). "Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family". Dev. Biol. 183 (2): 166–82. doi: 10.1006/dbio.1996.8486 . PMID   9126292.
• Ding H, Benotmane AM, Suske G, et al. (1999). "Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene". J. Biol. Chem. 274 (28): 19573–80. doi: 10.1074/jbc.274.28.19573 . PMID   10391891.
• Mansharamani M, Hewetson A, Chilton BS (2001). "Cloning and characterization of an atypical Type IV P-type ATPase that binds to the RING motif of RUSH transcription factors". J. Biol. Chem. 276 (5): 3641–9. doi: 10.1074/jbc.M004231200 . PMID   11058586.
• Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID   11810028.
• Moinova HR, Chen WD, Shen L, et al. (2002). "HLTF gene silencing in human colon cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4562–7. Bibcode:2002PNAS...99.4562M. doi: 10.1073/pnas.062459899 . PMC   123687 . PMID   11904375.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Leung WK, Yu J, Bai AH, et al. (2003). "Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer". Mol. Carcinog. 37 (2): 91–7. doi:10.1002/mc.10124. PMID   12766908. S2CID   46627646.
• Hamai Y, Oue N, Mitani Y, et al. (2004). "DNA hypermethylation and histone hypoacetylation of the HLTF gene are associated with reduced expression in gastric carcinoma". Cancer Sci. 94 (8): 692–8. doi: 10.1111/j.1349-7006.2003.tb01504.x . PMC   11160177 . PMID   12901794. S2CID   27311901.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Fukuoka T, Hibi K, Nakao A (2006). "Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma". Anticancer Res. 26 (5A): 3333–5. PMID   17094449.