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Aliases | HLTF , HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1, helicase-like transcription factor, helicase like transcription factor | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603257; MGI: 1196437; HomoloGene: 30136; GeneCards: HLTF; OMA:HLTF - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene. [5] [6]
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [6]
HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae RAD5 besides SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5. [7]
HLTF has been shown to interact with UBE2N, [8] RAD18 [8] and UBE2V2 [8] (see also STRING functional and physical associations network : under the option 'search by name' enter 'protein name' of interest, HLTF, klick on 'GO! ', choose 'organism ', klick on 'continue ->' ).
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.
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General transcription factor II-I repeat domain-containing protein 1 is a protein that in humans is encoded by the GTF2IRD1 gene.
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Myocardin is a protein that in humans is encoded by the MYOCD gene.
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Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.
Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.
Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.
Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.
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E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. In humans this protein is encoded by the ELF2 gene.
Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]
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