HNRPUL1

HNRNPUL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZRJ
Identifiers
Aliases	HNRNPUL1 , E1B-AP5, E1BAP5, HNRPUL1, heterogeneous nuclear ribonucleoprotein U like 1
External IDs	OMIM: 605800 MGI: 2443517 HomoloGene: 31419 GeneCards: HNRNPUL1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,307,787 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,454,182 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; sural nerve; ; gastric mucosa; ; stromal cell of endometrium; ; bone marrow cells; ; popliteal artery; ; canal of the cervix; ; monocyte; ; left uterine tube; ; right lung;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; molar; ; conjunctival fornix; ; thymus; ; maxillary prominence; ; ankle; ; seminiferous tubule; ; hair follicle; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	enzyme binding ; protein binding ; RNA binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	mRNA splicing, via spliceosome ; response to virus ; RNA processing ; regulation of transcription, DNA-templated ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	11100
	232989
	ENSG00000105323
	ENSMUSG00000040725
	Q9BUJ2
	Q8VDM6
NM_001301016 ; NM_007040 ; NM_144732 ; NM_144733 ; NM_144734 ;
	NM_001321208 ; NM_001321211
	NM_144922 ; NM_178089 ; NM_001360789
	NP_001287945 ; NP_001308137 ; NP_001308140 ; NP_008971 ; NP_653333 Contents Interactions ; References ; Further reading ;
	NP_659171 ; NP_835190 ; NP_001347718
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 05, 2024

Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.^[5]^[6]^[7]

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined.^[7]

Interactions

HNRPUL1 has been shown to interact with BRD7 ^[6] and PRMT2.^[8]

Related Research Articles

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene. It is found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as protein H16. Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.

Histone H4 is a protein that in humans is encoded by the HIST4H4 gene.

Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene.

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene. Alternative splicing of this gene results in four transcript variants.

Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the HNRNPC gene.

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.

Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.

Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AL gene.

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.

Heterogeneous nuclear ribonucleoprotein D-like, also known as HNRPDL, is a protein which in humans is encoded by the HNRPDL gene.

Exportin-T is a protein that in humans is encoded by the XPOT gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105323 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040725 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T (Oct 1998). "E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs". J Virol. 72 (10): 7960–71. doi:10.1128/JVI.72.10.7960-7971.1998. PMC 110131 . PMID 9733834.
1 2 Kzhyshkowska J, Rusch A, Wolf H, Dobner T (Apr 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277 . PMID 12489984.
1 2 "Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1".
↑ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062 . PMID 11513728.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bachi A, Braun IC, Rodrigues JP, et al. (2000). "The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates". RNA. 6 (1): 136–58. doi:10.1017/S1355838200991994. PMC 1369901 . PMID 10668806.
Herold A, Suyama M, Rodrigues JP, et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553 . PMID 11073998.
Kzhyshkowska J, Schütt H, Liss M, et al. (2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. PMC 1222062 . PMID 11513728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Kzhyshkowska J, Kremmer E, Hofmann M, et al. (2005). "Protein arginine methylation during lytic adenovirus infection". Biochem. J. 383 (Pt 2): 259–65. doi:10.1042/BJ20040210. PMC 1134066 . PMID 15242333.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barral PM, Rusch A, Turnell AS, et al. (2005). "The interaction of the hnRNP family member E1B-AP5 with p53". FEBS Lett. 579 (13): 2752–8. doi: 10.1016/j.febslet.2005.03.095 . PMID 15907477. S2CID 28875660.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shiffman D, Rowland CM, Louie JZ, et al. (2006). "Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction". Arterioscler. Thromb. Vasc. Biol. 26 (7): 1613–8. doi: 10.1161/01.ATV.0000226543.77214.e4 . PMID 16690874.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Kollers S, Musilova P, Rubes J, Rocha D (2007). "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13". Anim. Genet. 37 (6): 595–6. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105323 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040725 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9733834-5] Gabler S, Schutt H, Groitl P, Wolf H, Shenk T, Dobner T (Oct 1998). "E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs". J Virol. 72 (10): 7960–71. doi:10.1128/JVI.72.10.7960-7971.1998. PMC 110131 . PMID 9733834.

[pmid12489984-6] 1 2 Kzhyshkowska J, Rusch A, Wolf H, Dobner T (Apr 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277 . PMID 12489984.

[entrez-7] 1 2 "Entrez Gene: HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1".

[pmid11513728-8] Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062 . PMID 11513728.

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HNRPUL1

Contents

Interactions

Related Research Articles

References

Further reading