HOMER2

Last updated
HOMER2
Protein HOMER2 PDB 1i7a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HOMER2 , ACPD, CPD, HOMER-2, VESL-2, DFNA68, homer scaffolding protein 2, homer scaffold protein 2
External IDs OMIM: 604799 MGI: 1347354 HomoloGene: 3560 GeneCards: HOMER2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004839
NM_199330
NM_199331
NM_199332

NM_001164086
NM_001164087
NM_011983
NM_177029

RefSeq (protein)

NP_004830
NP_955362

NP_001157558
NP_001157559
NP_036113

Location (UCSC) Chr 15: 82.84 – 82.99 Mb Chr 7: 81.6 – 81.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene. [5] [6] [7]

Contents

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene. [7]

Interactions

HOMER2 has been shown to interact with RYR1. [8]

See also

Related Research Articles

Glutamate receptor

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate is abundant in the human body, but particularly in the nervous system and especially prominent in the human brain where it is the body's most prominent neurotransmitter, the brain's main excitatory neurotransmitter, and also the precursor for GABA, the brain's main inhibitory neurotransmitter. Glutamate receptors are responsible for the glutamate-mediated postsynaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation.

GRIA3

Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene.

ITPR1

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.

PICK1

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.

Metabotropic glutamate receptor 1

The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.

Metabotropic glutamate receptor 3

Metabotropic glutamate receptor 3 (mGluR3) is an inhibitory Gi/G0-coupled G-protein coupled receptor (GPCR) generally localized to presynaptic sites of neurons in classical circuits. However, in higher cortical circuits in primates, mGluR3 are localized post-synaptically, where they strengthen rather than weaken synaptic connectivity. In humans, mGluR3 is encoded by the GRM3 gene. Deficits in mGluR3 signaling have been linked to impaired cognition in humans, and to increased risk of schizophrenia, consistent with their expanding role in cortical evolution.

Metabotropic glutamate receptor 5

Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene.

Metabotropic glutamate receptor 6

Glutamate receptor, metabotropic 6, also known as GRM6 or mGluR6, is a protein which in humans is encoded by the GRM6 gene.

Metabotropic glutamate receptor 7

Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene.

GRIA1

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.

GRIA2

Glutamate ionotropic receptor AMPA type subunit 2 is a protein that in humans is encoded by the GRIA2 gene and it is a subunit found in the AMPA receptors.

HOMER1

Homer protein homolog 1 or Homer1 is a neuronal protein that in humans is encoded by the HOMER1 gene. Other names are Vesl and PSD-Zip45.

GRIK1

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.

SHANK2

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

GRIP1 (gene)

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.

DNM3

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.

SHANK1

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.

GRIP2

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.

HOMER3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.

GRIK5

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103942 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025813 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Dec 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi: 10.1016/S0896-6273(00)80589-9 . PMID   9808459.
  6. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (Dec 1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. doi: 10.1016/S0896-6273(00)80588-7 . PMID   9808458.
  7. 1 2 "Entrez Gene: HOMER2 homer homolog 2 (Drosophila)".
  8. Feng, Wei; Tu Jiancheng; Yang Tianzhong; Vernon Patty Shih; Allen Paul D; Worley Paul F; Pessah Isaac N (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". J. Biol. Chem. United States. 277 (47): 44722–30. doi: 10.1074/jbc.M207675200 . ISSN   0021-9258. PMID   12223488.

Further reading