HOOK2

HOOK2
Identifiers
Aliases	HOOK2 , HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDs	OMIM: 607824; MGI: 2181664; HomoloGene: 8332; GeneCards: HOOK2; OMA:HOOK2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 12,763,003 bp [1] End 12,872,740 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C3 Start 84,990,603 bp [2] End 85,003,349 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland apex of heart left lobe of thyroid gland body of pancreas anterior pituitary right uterine tube minor salivary glands skin of abdomen mucosa of transverse colon skin of leg Top expressed in spermatid yolk sac right kidney proximal tubule intestinal villus spermatocyte jejunum Hindgut seminiferous tubule neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding identical protein binding microtubule binding dynein light intermediate chain binding Cellular component HOPS complex cytoplasm microtubule organizing center centrosome microtubule cytoskeleton FHF complex cytosol intracellular membrane-bounded organelle Biological process protein transport lysosome organization early endosome to late endosome transport endocytosis endosome organization endosome to lysosome transport cytoskeleton-dependent intracellular transport cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29911 170833 Ensembl ENSG00000095066 ENSMUSG00000052566 UniProt Q96ED9 Q7TMK6 RefSeq (mRNA) NM_001100176 NM_013312 NM_001167991 NM_133255 NM_001363497 NM_001363498 RefSeq (protein) NP_001093646 NP_037444 NP_001161463 NP_573518 NP_001350426 NP_001350427 NP_001359286 NP_001359287 NP_001359288 NP_001359289 NP_001359290 NP_001359291 Location (UCSC) Chr 19: 12.76 – 12.87 Mb Chr 8: 84.99 – 85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Hook homolog 2 (HK2) is a protein ^[5] that in humans is encoded by the HOOK2 gene. ^{[6] [7]}

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000095066 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052566 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC   1460498 . PMID   9927460.
6. Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC   2198811 . PMID   11238449.
7. "Entrez Gene: hook homolog 2 (Drosophila)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex". Mol. Biol. Cell. 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC   2592673 . PMID   18799622.
• Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome". Mol. Biol. Cell. 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC   2777108 . PMID   19793914.
• Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8 19. doi: 10.1186/1471-2121-8-19 . PMC   1896156 . PMID   17540036.
• Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function". Traffic. 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID   17140400. S2CID   19664393.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi: 10.1111/j.1600-0854.2005.00289.x . PMID   15882442. S2CID   25389776.