HSPB2

HSPB2
Identifiers
Aliases	HSPB2 , HSP27, Hs.78846, LOH11CR1K, MKBP, heat shock protein family B (small) member 2
External IDs	OMIM: 602179; MGI: 1916503; HomoloGene: 68189; GeneCards: HSPB2; OMA:HSPB2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.1 Start 111,912,734 bp [1] End 111,914,093 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A5.3|9 27.75 cM Start 50,662,378 bp [2] End 50,663,654 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart apex of heart muscle of thigh left ventricle gastrocnemius muscle Descending thoracic aorta ascending aorta popliteal artery tibial arteries gastric mucosa Top expressed in interventricular septum extraocular muscle plantaris muscle cardiac muscle tissue of left ventricle extensor digitorum longus muscle right ventricle muscle of thigh soleus muscle temporal muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme activator activity protein binding Cellular component cytoplasm cytosol nucleus Biological process response to unfolded protein positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3316 69253 Ensembl ENSG00000170276 ENSMUSG00000038086 UniProt Q16082 Q99PR8 RefSeq (mRNA) NM_001541 NM_001164708 NM_024441 RefSeq (protein) NP_001532 NP_001158180.1 NP_077761.3 Location (UCSC) Chr 11: 111.91 – 111.91 Mb Chr 9: 50.66 – 50.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene. ^{[5] [6] [7]}

Interactions

HSPB2 has been shown to interact with:

• CRYAB, ^[8]
• HSPB8, ^{[9] [10]}
• Myotonic dystrophy protein kinase ^{[6] [8]} and
• TRAF6. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000170276 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038086 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (February 1998). "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner". Genomics. 45 (2): 386–94. doi:10.1006/geno.1997.4956. PMID   9344664.
6. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (April 1998). "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol. 140 (5): 1113–24. doi:10.1083/jcb.140.5.1113. PMC   2132705 . PMID   9490724.
7. "Entrez Gene: HSPB2 heat shock 27kDa protein 2".
8. Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (January 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. 275 (2): 1095–104. doi: 10.1074/jbc.275.2.1095 . PMID   10625651.
9. Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R (January 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. 279 (4): 2394–402. doi: 10.1074/jbc.M311324200 . PMID   14594798.
10. Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ (July 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. 276 (29): 26753–61. doi: 10.1074/jbc.M103001200 . PMID   11342557.
11. Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z (January 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID   18950704.

Further reading

• Concannon CG, Gorman AM, Samali A (2003). "On the role of Hsp27 in regulating apoptosis". Apoptosis. 8 (1): 61–70. doi:10.1023/A:1021601103096. PMID   12510153. S2CID   18464958.
• Elisei R, Weightman D, Kendall-Taylor P, Vassart G, Ludgate M (1993). "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics". J. Endocrinol. Invest. 16 (7): 533–40. doi:10.1007/bf03348900. PMID   8227983. S2CID   23857370.
• Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC   1170775 . PMID   9687510.
• Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. 275 (2): 1095–104. doi: 10.1074/jbc.275.2.1095 . PMID   10625651.
• Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B (2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region". Eur. J. Hum. Genet. 9 (2): 121–9. doi: 10.1038/sj.ejhg.5200585 . PMID   11313745.
• Nakagawa M, Tsujimoto N, Nakagawa H, Iwaki T, Fukumaki Y, Iwaki A (2001). "Association of HSPB2, a member of the small heat shock protein family, with mitochondria". Exp. Cell Res. 271 (1): 161–8. doi:10.1006/excr.2001.5362. PMID   11697892.
• Ito H, Kamei K, Iwamoto I, Inaguma Y, García-Mata R, Sztul E, Kato K (2002). "Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes". J. Biochem. 131 (4): 593–603. doi:10.1093/oxfordjournals.jbchem.a003139. PMID   11926998.
• Boxman IL, Kempenaar J, de Haas E, Ponec M (2003). "Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C.". Exp. Dermatol. 11 (6): 509–17. doi:10.1034/j.1600-0625.2002.110603.x. PMID   12473058. S2CID   25384331.
• Patel VM, Heinel LA, Provencio JJ, Vinall PE, Kramer MS, Rosenwasser RH (2003). "Validation of image analysis for enzyme histochemical and immunocytochemical staining". Biotechnic & Histochemistry. 77 (4): 213–21. doi:10.1080/714028196. PMID   12503731.
• Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC (2003). "hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells". J. Biol. Chem. 278 (20): 18214–20. doi: 10.1074/jbc.M300126200 . PMID   12611892.
• Yonekura N, Yokota S, Yonekura K, Dehari H, Arata S, Kohama G, Fujii N (2003). "Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines". Cell Death Differ. 10 (3): 313–22. doi: 10.1038/sj.cdd.4401169 . PMID   12700631.
• Kantham L, Kerr-Bayles L, Godde N, Quick M, Webb R, Sunderland T, Bond J, Walder K, Augert G, Collier G (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID   12705895.
• Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY (2003). "Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72". Mol. Cell. Biol. 23 (11): 3813–24. doi:10.1128/MCB.23.11.3813-3824.2003. PMC   155207 . PMID   12748284.
• Park KJ, Gaynor RB, Kwak YT (2003). "Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation". J. Biol. Chem. 278 (37): 35272–8. doi: 10.1074/jbc.M305095200 . PMID   12829720.
• Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M (2003). "Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3". FEBS Lett. 546 (2–3): 307–14. Bibcode:2003FEBSL.546..307W. doi: 10.1016/S0014-5793(03)00605-7 . PMID   12832059. S2CID   35025906.
• Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantôme A, Plenchette S, Khochbin S, Solary E, Garrido C (2003). "HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation". Mol. Cell. Biol. 23 (16): 5790–802. doi:10.1128/MCB.23.16.5790-5802.2003. PMC   166315 . PMID   12897149.