HSPB6

Last updated
HSPB6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HSPB6 , HEL55, Hsp20, PPP1R91, heat shock protein family B (small) member 6
External IDs OMIM: 610695 MGI: 2685325 HomoloGene: 36931 GeneCards: HSPB6
Orthologs
SpeciesHumanMouse
Entrez

126393

243912

Ensembl

ENSG00000004776

ENSMUSG00000036854

UniProt

O14558

Q5EBG6

RefSeq (mRNA)

NM_144617

NM_001012401
NM_001364179

RefSeq (protein)

NP_653218

NP_001012401
NP_001351108

Location (UCSC) Chr 19: 35.75 – 35.76 Mb Chr 7: 30.25 – 30.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene. [5] [6] [7]

Contents

HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin). [8]

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance [9] and in smooth and cardiac muscle. [10] [11]

Related Research Articles

Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans.

In anatomy, a crystallin is a water-soluble structural protein found in the lens and the cornea of the eye accounting for the transparency of the structure. It has also been identified in other places such as the heart, and in aggressive breast cancer tumors. Since it has been shown that lens injury may promote nerve regeneration, crystallin has been an area of neural research. So far, it has been demonstrated that crystallin β b2 (crybb2) may be a neurite-promoting factor.

<span class="mw-page-title-main">Hsp27</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene.

<span class="mw-page-title-main">CRYAB</span> Protein-coding gene in the species Homo sapiens

Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications decrease the ability to chaperone. Mutations in CRYAB cause different cardiomyopathies, skeletal myopathies mainly myofibrillar myopathy, and also cataracts. In addition, defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

<span class="mw-page-title-main">HSP90AB1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene.

<span class="mw-page-title-main">PTGES3</span> Protein-coding gene in the species Homo sapiens

Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene.

<span class="mw-page-title-main">DNAJB1</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.

<span class="mw-page-title-main">DNAJA1</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

<span class="mw-page-title-main">HSPB2</span> Protein-coding gene in the species Homo sapiens

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.

<span class="mw-page-title-main">HSPH1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.

<span class="mw-page-title-main">CRYGB</span> Protein-coding gene in the species Homo sapiens

Gamma-crystallin B is a protein that in humans is encoded by the CRYGB gene.

<span class="mw-page-title-main">CRYGS</span> Protein-coding gene in the species Homo sapiens

Gamma-crystallin S is a protein that in humans is encoded by the CRYGS gene.

<span class="mw-page-title-main">TRAP1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

<span class="mw-page-title-main">HSF4</span> Protein-coding gene in the species Homo sapiens

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.

<span class="mw-page-title-main">HSPA6</span> Protein-coding gene in the species Homo sapiens

Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene.

<span class="mw-page-title-main">CRYZ</span> Protein-coding gene in the species Homo sapiens

Quinone oxidoreductase is an enzyme that in humans is encoded by the CRYZ gene.

<span class="mw-page-title-main">CRYGA</span> Protein-coding gene in the species Homo sapiens

Gamma-crystallin A is a protein that in humans is encoded by the CRYGA gene.

<span class="mw-page-title-main">CRYAA</span> Protein-coding gene in the species Homo sapiens

Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene.

The heat shock protein Hsp20 family, also known as small heat shock proteins (sHSPs), is a family of heat shock proteins.

<span class="mw-page-title-main">HSPB3</span> Protein-coding gene in the species Homo sapiens

Heat shock protein beta-3 (HspB3) also known as heat shock 27kDa protein 3 is a protein that in humans is encoded by the HSPB3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000004776 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036854 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress & Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 (inactive 2024-04-11). PMC   514853 . PMID   12820654.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
  6. ↑ Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID   14717697.
  7. ↑ "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6".
  8. ↑ Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. doi: 10.1016/S0021-9258(17)36606-1 . PMID   8195168.
  9. ↑ Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress & Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC   2866971 . PMID   19568960.
  10. ↑ Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC   2581864 . PMID   18579210.
  11. ↑ Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID   16099377.

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