HSPB6

HSPB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JUS, 4JUT
Identifiers
Aliases	HSPB6 , HEL55, Hsp20, PPP1R91, heat shock protein family B (small) member 6
External IDs	OMIM: 610695; MGI: 2685325; HomoloGene: 36931; GeneCards: HSPB6; OMA:HSPB6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.12 Start 35,754,566 bp [1] End 35,758,079 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 30,251,603 bp [2] End 30,254,868 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart gastrocnemius muscle decidua right coronary artery left coronary artery left uterine tube canal of the cervix popliteal artery tibial arteries Top expressed in interventricular septum extraocular muscle temporal muscle ankle soleus muscle vastus lateralis muscle sternocleidomastoid muscle muscle of thigh triceps brachii muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of eye lens protein homodimerization activity protein binding unfolded protein binding chaperone binding Cellular component nucleus cytoplasm extracellular region Biological process regulation of muscle contraction negative regulation of cardiac muscle cell apoptotic process positive regulation of angiogenesis chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 126393 243912 Ensembl ENSG00000004776 ENSMUSG00000036854 UniProt O14558 Q5EBG6 RefSeq (mRNA) NM_144617 NM_001012401 NM_001364179 RefSeq (protein) NP_653218 NP_001012401 NP_001351108 Location (UCSC) Chr 19: 35.75 – 35.76 Mb Chr 7: 30.25 – 30.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene. ^{[5] [6] [7]}

HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin). ^[8]

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance ^[9] and in smooth and cardiac muscle. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000004776 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036854 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress & Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 (inactive 12 July 2025). PMC   514853 . PMID   12820654.
6. Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID   14717697.
7. "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6".
8. Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. doi: 10.1016/S0021-9258(17)36606-1 . PMID   8195168.
9. Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress & Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC   2866971 . PMID   19568960.
10. Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC   2581864 . PMID   18579210.
11. Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID   16099377.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fontaine JM, Sun X, Benndorf R, Welsh MJ (2005). "Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3". Biochem. Biophys. Res. Commun. 337 (3): 1006–11. doi:10.1016/j.bbrc.2005.09.148. PMID   16225851.
• Flynn CR, Smoke CC, Furnish E, et al. (2007). "Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli". Protein Expr. Purif. 52 (1): 50–8. doi:10.1016/j.pep.2006.08.015. PMC   1839877 . PMID   17084643.
• Chernik IS, Seit-Nebi AS, Marston SB, Gusev NB (2007). "Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma". Mol. Cell. Biochem. 295 (1–2): 9–17. doi:10.1007/s11010-006-9266-8. PMID   17109079. S2CID   6389210.

External links

• Overview of all the structural information available in the PDB for UniProt : O14558 (Heat shock protein beta-6) at the PDBe-KB .