Harlan Krumholz | |
---|---|
Occupation(s) | Cardiologist Professor of Medicine |
Spouse | Leslie Krumholz |
Academic background | |
Education | BS, Biology, 1980, Yale University MD, 1985, Harvard University |
Academic work | |
Institutions | Yale University School of Medicine Yale New Haven Hospital |
Harlan M. Krumholz is an American cardiologist. He is the Harold H. Hines Jr. Professor of Medicine at Yale University School of Medicine. Krumholz's research is aimed at determining optimal clinical strategies and identifying opportunities for improvement in the prevention,treatment and outcome of cardiovascular disease
Krumholz earned his Bachelor of Science degree in biology from Yale University in 1980 and his medical degree from Harvard University in 1985. [1] As an undergraduate at Yale University,Krumholz was granted an opportunity to complete an internship at the North Carolina Office of Rural Health &Community. [2] Following this,he completed his medical fellowship at Beth Israel Hospital/Harvard Medical School and residency at the University of California,San Francisco. [1]
Krumholz joined the faculty at the Yale University School of Medicine in 1992,where he then directed the Robert Wood Johnson Foundation Clinical Scholars Program. [1] While serving in this role,he convinced Medicare to give him access to detailed patient data from heart doctors in Alabama,Connecticut,Iowa and Wisconsin in order to create a database of 16,000 patients. Using this data,he concluded that half the patients hospitalized for heart failure returned to the hospital within six months. He also found in 2004 that although angioplasty was successful in reopening clogged arteries,only 33% of patients were getting angioplasty when needed. [3] He also served as an editor for the NEJM journal Watch Cardiology since 1995 and Editor-in-Chief since 2000. [4]
In 2005,Krumholz was appointed the Harold H. Hines Jr. Professor of Medicine and published The Expert Guide to Beating Heart Disease:What You Absolutely Must Know through HarperResource. [5] In recognition of his "research aimed at determining optimal clinical strategies and identifying opportunities for improvement in the prevention,treatment and outcome of cardiovascular disease," Krumholz was elected a Member of the Institute of Medicine. [6]
While serving as the director of the Center for Outcomes Research and Evaluation at Yale New Haven Hospital,Krumholz co-established HUGO,a cloud-based personal health record. The aim of HUGO was to allow patients to access their health records electronically across multiple healthcare systems and synchronize those records with a research database. [7] In 2017,Krumholz was named to serve on Ned Lamont's inaugural governing committee for the National Evaluation System for Health Technology Coordinating Center (NEST) [8] and his transition committees for health care. [9]
Krumholz continued his research into heart attacks by tracking Medicare patients across the United States. He found that hospitalizations for heart attacks have declined by 38% since 1990 and the mortality rate for heart attacks was at only 12%. [10] In 2018,Krumholz and Erica Spatz were co-recipients of a $1.2 million,four-year grant from the National Institute of Biomedical Imaging and Bioengineering to develop a wrist-worn,cuffless blood pressure monitoring system. [11] He was recognized for his efforts by the American Heart Association with the 2018 Clinical Research Prize. [12] The following year,he collaborated with Chenxi Huang to develop a new mathematical model that could predict the risk of acute kidney injury. [13]
During the COVID-19 pandemic in North America,Krumholz co-founded a website called medRxiv which was intended to be used for sharing preliminary medical research. Using a $2 million award from the Chan Zuckerberg Initiative,the website allows scientists to share new discoveries and research findings in the clinical and health sciences to accelerate possible treatments. [14]
Krumholz is married to Leslie Krumholz,co-founder of The Guilford Fund for Education and CEO of GoodStreets. [15]
Rosiglitazone is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer,by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride. First released in 1999,annual sales peaked at approximately $2.5-billion in 2006;however,following a meta-analysis in 2007 that linked the drug's use to an increased risk of heart attack,sales plummeted to just $9.5-million in 2012. The drug's patent expired in 2012.
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Professor Sir Bruce Edward Keogh,KBE,FMedSci,FRCS,FRCP is a Rhodesian-born British surgeon who specialises in cardiac surgery. He was medical director of the National Health Service in England from 2007 and national medical director of the NHS Commissioning Board from 2013 until his retirement early in 2018. He is chair of Birmingham Women's and Children's NHS Foundation Trust and chairman of The Scar Free Foundation.
Percutaneous coronary intervention (PCI) is a minimally invasive non-surgical procedure used to treat narrowing of the coronary arteries of the heart found in coronary artery disease. The procedure is used to place and deploy coronary stents,a permanent wire-meshed tube,to open narrowed coronary arteries. PCI is considered 'non-surgical' as it uses a small hole in a peripheral artery (leg/arm) to gain access to the arterial system,an equivalent surgical procedure would involve the opening of the chest wall to gain access to the heart area. The term 'coronary angioplasty with stent' is synonymous with PCI. The procedure visualises the blood vessels via fluoroscopic imaging and contrast dyes. PCI is performed by an interventional cardiologists in a catheterization laboratory setting.
The Duke University School of Medicine,commonly known as Duke Med,is the medical school of Duke University. It was established in 1925 by James B. Duke.
Dean Michael Ornish is an American physician and researcher. He is the president and founder of the nonprofit Preventive Medicine Research Institute in Sausalito,California,and a Clinical Professor of Medicine at the University of California,San Francisco. The author of Dr. Dean Ornish's Program for Reversing Heart Disease,Eat More,Weigh Less and The Spectrum, he is an advocate for using diet and lifestyle changes to treat and prevent heart disease.
A drug-eluting stent (DES) is a tube made of a mesh-like material used to treat narrowed arteries in medical procedures both mechanically and pharmacologically. A DES is inserted into a narrowed artery using a balloon. Once the balloon inside the stent is inflated,the stent expands,pushing against the artery wall,keeping the artery open,thereby improving blood flow. The mesh design allows cells to grow through and around it,securing it in place.
The history of invasive and interventional cardiology is complex,with multiple groups working independently on similar technologies. Invasive and interventional cardiology is currently closely associated with cardiologists,though the development and most of its early research and procedures were performed by diagnostic and interventional radiologists.
A coronary stent is a tube-shaped device placed in the coronary arteries that supply blood to the heart,to keep the arteries open in patients suffering from coronary heart disease. The vast majority of stents used in modern interventional cardiology are drug-eluting stents (DES). They are used in a medical procedure called percutaneous coronary intervention (PCI). Coronary stents are divided into two broad types:drug-eluting and bare metal stents. As of 2023,drug-eluting stents were used in more than 90% of all PCI procedures. Stents reduce angina and have been shown to improve survival and decrease adverse events after a patient has suffered a heart attack—medically termed an acute myocardial infarction.
Albert Siu is a Cuban American internist and geriatrician and the Ellen and Howard C. Katz Chairman and Professor of the Brookdale Department of Geriatrics and Palliative Medicine at Mount Sinai Hospital in New York City. He is also the director of the Geriatric Research,Education,and Clinical Center at the James J. Peters VA Medical Center in The Bronx,a senior associate editor of Health Services Research,a senior fellow of the Brookdale Foundation and a former trustee of the Nathan Cummings Foundation.
Dr Purshotam Lal is an Indian Interventional cardiologist recognised internationally for pioneering over 20 interventional cardiology procedures in India. He is a Fellow of College of Physicians and Surgeons of Canada,American College of Medicine,Indian College of Cardiology,American College of Cardiology,Society of Cardiac Angiography &Interventions of USA. He is the Founder &Chairman of Metro Group of Hospitals.
Frederick A. Masoudi is an American cardiologist with expertise in cardiovascular outcomes research,clinical registries and quality measurement.
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Howard P. Forman is a professor of radiology,economics,public health,and management at Yale University. Forman is known for his commentary on the U.S. government's response to the COVID-19 pandemic,his political and healthcare writing on Twitter,and his role in developing national leaders in healthcare.
Samin K. Sharma is an American philanthropist of Indian descent and an interventional cardiologist who co-founded the Eternal Heart Care Centre and Research Institute in Jaipur (EHCC). Sharma has served on New York State’s Cardiac Advisory Board since 2004. As of 2021,he is Senior Vice-President,Operations &Quality at The Mount Sinai Hospital in New York and runs the Dr. Samin K. Sharma Family Foundation Cardiac Catheterization Laboratory. As of 2018,he is Chairman Board of Trustees,Association of Indians in America (AIA). As of 2022,he has been an investigator on 86 grants and multi-center trials and authored 486 peer-reviewed articles that have been cited 21,734 times.
Marcella Nunez-Smith is an American physician-scientist. She is C.N.H Long Professor of medicine and epidemiology at the Yale School of Medicine,where she serves as the inaugural Associate Dean for Health Equity Research and founding director of the Equity Research and Innovation Center. She also holds joint appointments at the Yale School of Public Health and the Yale School of Management. After co-chairing the Biden-Harris transition's COVID-19 Advisory Board from November 2020 to January 2021,she was selected by President Joe Biden to serve as Senior Advisor to the White House COVID-19 Response Team and Chair of the Presidential COVID-19 Equity Task Force.
Erica S. Spatz is an American general cardiologist. She is an associate professor and clinical investigator at the Center for Outcomes Research and Evaluation at the Yale University School of Medicine.
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Renee Yuen-Jan Hsia is an American emergency physician. She is a professor of Emergency Medicine and Associate Chair of Health Services Research at the University of California,San Francisco,as well as an attending physician in the emergency department at the Zuckerberg San Francisco General Hospital and Trauma Center. She is also a core faculty member of the UCSF Philip R. Lee Institute for Health Policy Studies. Her research is aimed at studying how health services and regionalization of care impact access to emergency care.
Harlan Krumholz publications indexed by Google Scholar