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References
- 1 2 3 Azar, Beth (20 December 2016). "Profile of Harris A. Lewin". Proceedings of the National Academy of Sciences of the United States of America. 113 (51): 14468–14470. Bibcode:2016PNAS..11314468A. doi: 10.1073/pnas.1618868114 . PMC 5187711 . PMID 27956630.
- ↑ "Harris Lewin named director of Post Genomic Institute" (Press release). University of Illinois. 2 May 2003. Retrieved July 14, 2020.
- 1 2 3 "Harris Lewin Elected to National Academy of Sciences" (Press release). Carl R. Woese Institute for Genomic Biology. 30 April 2012. Retrieved July 14, 2020.
- 1 2 3 "Illinois professor awarded 2011 Wolf Prize in Agriculture" (Press release). University of Illinois. 15 February 2011. Retrieved July 14, 2020.
- 1 2 3 Lewin, Harris A.; Robinson, Gene E.; Kress, W. John; Baker, William J.; Coddington, Jonathan; Crandall, Keith A.; Durbin, Richard; Edwards, Scott V.; Forest, Félix; Gilbert, M. Thomas P.; Goldstein, Melissa M.; Grigoriev, Igor V.; Hackett, Kevin J.; Haussler, David; Jarvis, Erich D.; Johnson, Warren E.; Patrinos, Aristides; Richards, Stephen; Castilla-Rubio, Juan Carlos; van Sluys, Marie-Anne; Soltis, Pamela S.; Xu, Xun; Yang, Huanming; Zhang, Guojie (24 April 2018). "Earth BioGenome Project: Sequencing life for the future of life". Proceedings of the National Academy of Sciences. 115 (17): 4325–4333. Bibcode:2018PNAS..115.4325L. doi: 10.1073/pnas.1720115115 . PMC 5924910 . PMID 29686065.
- ↑ "Introduction". Annual Review of Animal Biosciences. 1. 2013. doi:10.1146/annurev-av-1-012513-100001.
- ↑ "Harris Lewin | College of Biological Sciences". biosci3.ucdavis.edu. Archived from the original on 2015-09-06.
- ↑ "Harris A. Lewin, Ph.D." www.igb.illinois.edu. Archived from the original on 2016-08-12.
- ↑ "Personnel, Laboratory of Mammalian Genome Biology, University of Illinois at Urbana-Champaign". lewinlab.igb.uiuc.edu. Archived from the original on 2008-07-08.
- ↑ "History". Carl R. Woese Institute for Genomic Biology . Retrieved 7 November 2015.
- ↑ "Research VC Lewin to Step Down". UC Davis. 9 February 2016. Retrieved 2017-07-27.
- ↑ Pennisi, Elizabeth (24 February 2017). "Biologists propose to sequence the DNA of all life on Earth". Science. doi:10.1126/science.aal0824.
- ↑ "How a Genetic Mutation From 1 Bull Caused the Loss of Half a Million Calves Worldwide" (Press release). UC Davis. 13 October 2016. Retrieved July 14, 2020.
- ↑ Zhang, Sarah (31 October 2016). "The Dairy Industry Lost $420 Million From a Flaw in a Single Bull". The Atlantic.
- ↑ Main, Douglas (15 November 2016). "One bull's genes gave 14 percent of U.S. dairy cows a deadly mutation". Newsweek.
- ↑ "El ejemplar de toro que transformó la industria lechera mundial" [The bull that transformed the world dairy industry with 16,000 calves]. BBC News Mundo (in Spanish). 1 November 2016.
- ↑ "Cow Gene Study Shows Why Most Clones Fail". UC Davis. 9 December 2016. Retrieved 2017-07-27.
- ↑ Kim, Jaebum; Farré, Marta; Auvil, Loretta; Capitanu, Boris; Larkin, Denis M.; Ma, Jian; Lewin, Harris A. (3 July 2017). "Reconstruction and evolutionary history of eutherian chromosomes". Proceedings of the National Academy of Sciences. 114 (27): E5379–E5388. Bibcode:2017PNAS..114E5379K. doi: 10.1073/pnas.1702012114 . PMC 5502614 . PMID 28630326.
- ↑ "Reconstruction of Ancient Chromosomes Offers Insight Into Mammalian Evolution". UC Davis. 21 June 2017. Retrieved 2017-07-27.
- ↑ "Earth BioGenome Project to Sequence All Life". UC Davis. 23 January 2018. Retrieved 2018-09-06.
- ↑ "New Partnership Aims to Sequence Genomes of All Life on Earth, Unlock Nature's Value, Tackle Bio-Piracy and Habitat Loss". World Economic Forum. Retrieved 2018-09-06.