Holdemanella is a genus of Gram-positive, strictly anaerobic bacteria in the family Erysipelotrichaceae. Members of this genus are non-spore-forming, rod-shaped fermenters that produce short-chain fatty acids such as butyrate. They are commonly found in the intestinal tracts of mammals and are implicated in host metabolic health.
The genus Holdemanella was established by De Maesschalck et al. in 2014 to reclassify Eubacterium biforme as Holdemanella biformis based on 16S rRNA gene phylogeny and phenotypic traits.[1]
A second species, Holdemanella porci, was described in 2021 by Wylensek et al., after isolation from the feces of a 37-week-old pig in Bavaria, Germany.[2]
Etymology
The genus is named after Lillian Haldeman Moore (L.V. Holdeman), a pioneer in the field of anaerobic bacteriology. The species name biformis refers to its variable morphology, while porci (Latin, “of the pig”) reflects the porcine origin of the second species.
Both species of Holdemanella are members of the gut microbiota:
H. biformis has been isolated from the human colon and feces of other mammals.
H. porci was recovered from the gastrointestinal tract of pigs.
Species
Holdemanella biformis
The type species, H. biformis, is found in the human colon. It has been studied for its role in improving glucose metabolism and stimulating GLP-1 hormone signaling in obese mice, indicating potential metabolic benefits.[3]
Holdemanella porci
Described in 2020, H. porci was isolated from a healthy pig. Its genome and fermentation profile suggest a role in carbohydrate metabolism, but its specific effects on host physiology remain under investigation.[4]
↑ De Maesschalck, C.; Van Immerseel, F.; Eeckhaut, V.; De Baere, S.; Cnockaert, M.; Croubels, S.; Haesebrouck, F.; Ducatelle, R.; Vandamme, P. (November 2014). "Faecalicoccus acidiformans gen. nov., sp. nov., and reclassification of several Eubacterium and Streptococcus species including Holdemanella biformis gen. nov., comb. nov". International Journal of Systematic and Evolutionary Microbiology. 64 (11): 3877–3884. doi:10.1099/ijs.0.064626-0. PMID25180093.
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