Hypoalphalipoproteinemia

Hypoalphalipoproteinemia
Hypoalphalipoproteinemia has an autosomal dominant pattern of inheritance.
Specialty	Endocrinology

Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant manner. ^[1]

It can be associated with LDL receptor. ^[2]

Associated regions and genes include:

Name	OMIM	Locus	Candidates
HDLCQ1	606613	9p	ABCA1 (Tangier disease) [3]
HDLCQ2	607053	8q23
HDLCQ3	607687	16q24.1	Lecithin cholesterol acyltransferase deficiency (LCAT)
HDLCQ4	610239	4q32
HDLD3	605201	11q23.3	APOA1

Niacin is sometimes prescribed to raise HDL levels.^{[ citation needed ]}

See also

• CER-001

References

1. Online Mendelian Inheritance in Man (OMIM): 604091
2. Pisciotta L, Calabresi L, Lupattelli G, et al. (September 2005). "Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes". Atherosclerosis. 182 (1): 153–9. doi:10.1016/j.atherosclerosis.2005.01.048. hdl: 11380/449950 . PMID   16115486.
3. Soro-Paavonen A, Naukkarinen J, Lee-Rueckert M, et al. (June 2007). "Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL". J. Lipid Res. 48 (6): 1409–16. doi: 10.1194/jlr.P600012-JLR200 . PMID   17372331.