IFT81

Last updated
IFT81
Identifiers
Aliases IFT81 , CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs OMIM: 605489 MGI: 1098597 HomoloGene: 7664 GeneCards: IFT81
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009879
NM_001358917
NM_001358918
NM_001358919

RefSeq (protein)

NP_034009
NP_001345846
NP_001345847
NP_001345848

Location (UCSC) Chr 12: 110.12 – 110.22 Mb Chr 5: 122.69 – 122.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene. [5] [6] Together with IFT74/72 it forms a core complex to build IFT particles [7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170 [8] which regulates the disassembly of the cilium.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000122970 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029469 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
  6. Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID   11130971. S2CID   9319574.
  7. Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi: 10.1074/jbc.M505062200 . PMID   15955805.
  8. Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

Further reading