CEP170

CEP170
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JON
Identifiers
Aliases	CEP170 , FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDs	OMIM: 613023; MGI: 1918348; HomoloGene: 22844; GeneCards: CEP170; OMA:CEP170 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q43 Start 243,124,428 bp [1] End 243,255,348 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H4 Start 176,561,219 bp [2] End 176,641,633 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus callosum ventricular zone left testis right testis sural nerve C1 segment epithelium of colon Achilles tendon cerebellar cortex Top expressed in ganglionic eminence hand cumulus cell spermatid ventricular zone neural tube olfactory bulb lobe of cerebellum tail of embryo genital tubercle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 9859 545389 Ensembl ENSG00000143702 ENSG00000276725 ENSMUSG00000057335 UniProt Q5SW79 Q6A065 RefSeq (mRNA) NM_001042404 NM_001042405 NM_014812 NM_001024722 NM_001099637 NM_001368872 NM_001368873 RefSeq (protein) NP_001035863 NP_001035864 NP_055627 NP_001093107 NP_001355801 NP_001355802 Location (UCSC) Chr 1: 243.12 – 243.26 Mb Chr 1: 176.56 – 176.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene. ^{[5] [6]}

Function

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability. ^[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. ^[5]

References

1. ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057335 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CEP170 centrosomal protein 170kDa".
6. Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC   551476 . PMID   15616186.

External links

• Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC   551476 . PMID   15616186.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Lamla S (2009). Functional characterisation of the centrosomal protein Cep170. Dissertation, LMU Muenchen: Fakultät für Biologie (Text.PhDThesis). URN nbn:de:bvb:19-97838.