CEP192

Last updated
CEP192
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CEP192 , PPP1R62, centrosomal protein 192
External IDs OMIM: 616426 MGI: 1918049 HomoloGene: 73526 GeneCards: CEP192
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018069
NM_032142

NM_027556

RefSeq (protein)

NP_115518

n/a

Location (UCSC) Chr 18: 12.99 – 13.13 Mb Chr 18: 67.93 – 68.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. [5] [6] It is the homolog of the C. elegans and D. melanogaster gene SPD-2. [7]

Contents

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. [7] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. [8]

Related Research Articles

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In cell biology, the centrosome is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle progression. The centrosome provides structure for the cell. The centrosome is thought to have evolved only in the metazoan lineage of eukaryotic cells. Fungi and plants lack centrosomes and therefore use other structures to organize their microtubules. Although the centrosome has a key role in efficient mitosis in animal cells, it is not essential in certain fly and flatworm species.

<span class="mw-page-title-main">Spindle apparatus</span> Feature of biological cell structure

In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells. It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell.

<span class="mw-page-title-main">Aurora kinase A</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Ninein</span> Ninein (s.m. Al Ninein) in dialetto Bolognese è il maiale.

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<span class="mw-page-title-main">KIF2C</span> Protein-coding gene in the species Homo sapiens

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

<span class="mw-page-title-main">PCNT</span> Protein-coding gene in the species Homo sapiens

Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.

<span class="mw-page-title-main">CEP350</span> Protein-coding gene in the species Homo sapiens

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.

<span class="mw-page-title-main">TUBGCP2</span> Protein-coding gene in the species Homo sapiens

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma-tubulin complex, which is required for microtubule nucleation at the centrosome.

<span class="mw-page-title-main">CEP250</span> Protein-coding gene in the species Homo sapiens

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Furthermore, CEP135 is also required for the centriolar localization of CEP250.

<span class="mw-page-title-main">KATNA1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">CEP170</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.

<span class="mw-page-title-main">Centrin 1</span> Protein-coding gene in the species Homo sapiens

Centrin-1 is a protein that in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins.

<span class="mw-page-title-main">CEP70</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene. The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.

<span class="mw-page-title-main">CEP135</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material. CEP135 is required for the centriolar localization of CEP250.

<span class="mw-page-title-main">NEDD1</span> Protein-coding gene in the species Homo sapiens

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

<span class="mw-page-title-main">CEP164</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.

<span class="mw-page-title-main">CEP76</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

<span class="mw-page-title-main">CEP78</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.

<span class="mw-page-title-main">CEP152</span> Protein-coding gene in the species Homo sapiens

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.

<span class="mw-page-title-main">SFI1</span> Protein-coding gene in the species Homo sapiens

Sfi1 homolog, spindle assembly associated (yeast) is a protein that in humans is encoded by the SFI1 gene. It localizes to the centriole, and its S. pombe ortholog has been shown to be involved in spindle pole body duplication. SFI1 forms a complex with centrin 2.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101639 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024542 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: centrosomal protein 192kDa".
  6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
  7. 1 2 Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman A, Pelletier L (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology. 18 (2): 136–141. Bibcode:2008CBio...18..136Z. doi: 10.1016/j.cub.2007.12.055 . PMID   18207742. S2CID   16159409.
  8. Gomez-Ferreria M, Rath U, Buster D, Chanda S, Caldwell J, Rines D, Sharp D (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology. 17 (22): 1960–1966. Bibcode:2007CBio...17.1960G. doi: 10.1016/j.cub.2007.10.019 . PMID   17980596. S2CID   10245690.

Further reading