CEP192

CEP192
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4N7Z
Identifiers
Aliases	CEP192 , PPP1R62, centrosomal protein 192
External IDs	OMIM: 616426; MGI: 1918049; HomoloGene: 73526; GeneCards: CEP192; OMA:CEP192 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.21 Start 12,991,362 bp [1] End 13,125,052 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E1- E2 Start 67,933,177 bp [2] End 68,018,241 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gonad granulocyte Achilles tendon testicle right testis left testis secondary oocyte mucosa of transverse colon sperm Top expressed in genital tubercle tail of embryo hand spermatocyte secondary oocyte superior cervical ganglion epiblast zygote ventricular zone maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase binding protein binding Cellular component centriole centrosome pericentriolar material cytoskeleton cytoplasm cytosol Biological process negative regulation of phosphatase activity G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle protein localization to centrosome centrosome-templated microtubule nucleation mitotic spindle assembly response to bacterium centrosome duplication spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55125 70799 Ensembl ENSG00000101639 ENSMUSG00000024542 UniProt Q8TEP8 n/a RefSeq (mRNA) NM_018069 NM_032142 NM_027556 RefSeq (protein) NP_115518 n/a Location (UCSC) Chr 18: 12.99 – 13.13 Mb Chr 18: 67.93 – 68.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. ^{[5] [6]} It is the homolog of the C. elegans and D. melanogaster gene SPD-2. ^[7]

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. ^[7] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000101639 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024542 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: centrosomal protein 192kDa".
6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
7. Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, Müller-Reichert T, Kittler R, Hyman A, Pelletier L (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology. 18 (2): 136–141. Bibcode:2008CBio...18..136Z. doi: 10.1016/j.cub.2007.12.055 . PMID   18207742. S2CID   16159409.
8. Gomez-Ferreria M, Rath U, Buster D, Chanda S, Caldwell J, Rines D, Sharp D (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology. 17 (22): 1960–1966. Bibcode:2007CBio...17.1960G. doi: 10.1016/j.cub.2007.10.019 . PMID   17980596. S2CID   10245690.

External links

• Human CEP192 genome location and CEP192 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q8TEP8 (Centrosomal protein of 192 kDa) at the PDBe-KB .

Further reading

• Nagase T, Kikuno R, Nakayama M, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC   2291169 . PMID   7790358.
• Zhu F, Lawo S, Bird A, et al. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Curr. Biol. 18 (2): 136–41. Bibcode:2008CBio...18..136Z. doi: 10.1016/j.cub.2007.12.055 . PMID   18207742. S2CID   16159409.
• Gomez-Ferreria MA, Rath U, Buster DW, et al. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Curr. Biol. 17 (22): 1960–6. Bibcode:2007CBio...17.1960G. doi: 10.1016/j.cub.2007.10.019 . PMID   17980596. S2CID   10245690.
• Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC   2169446 . PMID   11076968.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC   2716422 . PMID   19615732.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC   124155 . PMID   12221128.
• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi: 10.1016/S1534-5807(03)00193-X . PMID   12852856.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC   1456919 . PMID   16462731.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID   15862967. S2CID   9746088.