CEP350

CEP350
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COZ
Identifiers
Aliases	CEP350 , CAP350, GM133, centrosomal protein 350
External IDs	OMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q25.2 Start 179,954,773 bp [1] End 180,114,875 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 G3 Start 155,720,710 bp [2] End 155,849,001 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm trabecular bone nipple left testis Achilles tendon right testis optic nerve pancreatic ductal cell jejunal mucosa gingival epithelium Top expressed in medullary collecting duct epithelium of stomach ciliary body pyloric antrum retinal pigment epithelium triceps brachii muscle vastus lateralis muscle Epithelium of choroid plexus temporal muscle mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding Cellular component centrosome spindle cytoskeleton membrane nucleus microtubule organizing center cytoplasm cell projection centriole Biological process microtubule anchoring Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9857 74081 Ensembl ENSG00000135837 ENSMUSG00000033671 UniProt Q5VT06 E9Q309 RefSeq (mRNA) NM_014810 NM_001039184 RefSeq (protein) NP_055625 NP_001034273 Location (UCSC) Chr 1: 179.95 – 180.11 Mb Chr 1: 155.72 – 155.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene. ^{[5] [6] [7]}

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles. ^[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC   1356575 . PMID   16314388.
6. Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi: 10.1242/jcs.01600 . PMID   15615782.
7. "Entrez Gene: CEP350 centrosomal protein 350kDa".
8. Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12) e3855. Bibcode:2008PLoSO...3.3855L. doi: 10.1371/journal.pone.0003855 . PMC   2586089 . PMID   19052644.

External links

• Human CEP350 genome location and CEP350 gene details page in the UCSC Genome Browser .

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
• Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene. 284 (1–2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID   11891061.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Hoppeler-Lebel A, Celati C, Bellett G, et al. (2007). "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex". J. Cell Sci. 120 (Pt 18): 3299–308. doi: 10.1242/jcs.013102 . PMID   17878239.