CEP76

CEP76
Identifiers
Aliases	CEP76 , C18orf9, HsT1705, centrosomal protein 76
External IDs	MGI: 1923401; HomoloGene: 11774; GeneCards: CEP76; OMA:CEP76 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.21 Start 12,661,833 bp [1] End 12,702,777 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E1 Start 67,750,870 bp [2] End 67,774,406 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm gonad testicle left testis right testis oral cavity gingival epithelium ventricular zone ganglionic eminence Top expressed in spermatocyte spermatid hand cerebellum human fetus otic vesicle Paneth cell cerebellar cortex secondary oocyte zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule organizing center centriole cytosol centrosome cytoskeleton protein-containing complex Biological process regulation of centriole replication G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79959 225659 Ensembl ENSG00000101624 ENSMUSG00000073542 UniProt Q8TAP6 Q0VEJ0 RefSeq (mRNA) NM_001271989 NM_024899 NM_001081073 NM_001357523 RefSeq (protein) NP_001258918 NP_079175 NP_001074542 NP_001344452 Location (UCSC) Chr 18: 12.66 – 12.7 Mb Chr 18: 67.75 – 67.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000101624 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073542 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: centrosomal protein 76kDa".
6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.

External links

• Human CEP76 genome location and CEP76 gene details page in the UCSC Genome Browser .

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. doi:10.1083/jcb.129.6.1617. PMC   2291169 . PMID   7790358.
• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi: 10.1016/S1534-5807(03)00193-X . PMID   12852856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion". J. Cell Biol. 151 (4): 837–46. doi:10.1083/jcb.151.4.837. PMC   2169446 . PMID   11076968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Rep. 7 (4): 418–24. doi:10.1038/sj.embor.7400639. PMC   1456919 . PMID   16462731.
• Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC   124155 . PMID   12221128.
• Tsang WY, Spektor A, Vijayakumar S, et al. (2009). "Cep76, a centrosomal protein that specifically restrains centriole reduplication". Dev. Cell. 16 (5): 649–60. doi:10.1016/j.devcel.2009.03.004. PMC   4062978 . PMID   19460342.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.