CEP68

CEP68
Identifiers
Aliases	CEP68 , KIAA0582, centrosomal protein 68
External IDs	OMIM: 616889; MGI: 2667663; HomoloGene: 65235; GeneCards: CEP68; OMA:CEP68 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p14 Start 65,056,366 bp [1] End 65,087,004 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 A3.1|11 12.92 cM Start 20,177,037 bp [2] End 20,199,429 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii glutes Skeletal muscle tissue of rectus abdominis skin of hip skin of thigh superficial temporal artery parietal pleura urethra nipple Top expressed in Rostral migratory stream digastric muscle extraocular muscle sternocleidomastoid muscle triceps brachii muscle soleus muscle temporal muscle abdominal wall vastus lateralis muscle myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein kinase binding protein binding Cellular component cell junction nucleus centrosome microtubule organizing center cytoskeleton cytoplasm cytosol Biological process protein localization to organelle centriole-centriole cohesion centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23177 216543 Ensembl ENSG00000011523 ENSMUSG00000044066 UniProt Q76N32 Q8C0D9 RefSeq (mRNA) NM_015147 NM_001319100 NM_001319101 NM_172260 RefSeq (protein) NP_001306029 NP_001306030 NP_055962 NP_758464 Location (UCSC) Chr 2: 65.06 – 65.09 Mb Chr 11: 20.18 – 20.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene. ^{[5] [6] [7] [8]} CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend on each other for centriole association, and both also require CEP250 for their function. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000011523 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044066 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
6. Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
7. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID   14654843. S2CID   4427303.
8. "Entrez Gene: CEP68 centrosomal protein 68kDa".
9. Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID   18042621. S2CID   7307094.

External links

• Human CEP68 genome location and CEP68 gene details page in the UCSC Genome Browser .

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID   12107410.
• Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK (Feb 2007). "Rate of evolution in brain-expressed genes in humans and other primates". PLOS Biology. 5 (2): e13. doi: 10.1371/journal.pbio.0050013 . PMC   1717015 . PMID   17194215.
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID   17570516. S2CID   23944956.